All Outputs (26)

Mining the archival formalin-fixed paraffin-embedded tissue proteome: opportunities and challenges (2008)
Journal Article
Nirmalan, N., Harnden, P., Selby, P., & Banks, R. (2008). Mining the archival formalin-fixed paraffin-embedded tissue proteome: opportunities and challenges. Molecular BioSystems, 4(7), 712-720. https://doi.org/10.1039/b800098k

The significant potential of tissue-based proteomic biomarker studies can be restricted by difficulties in accessing samples in optimal fresh-frozen form. While archival formalinfixed tissue collections with attached clinical and outcome data repre... Read More about Mining the archival formalin-fixed paraffin-embedded tissue proteome: opportunities and challenges.

Quantitative proteomics of the human malaria parasite Plasmodium falciparum and its application to studies of development and inhibition (2004)
Journal Article
Nirmalan, N., Sims, P. F. G., & Hyde, J. E. Quantitative proteomics of the human malaria parasite Plasmodium falciparum and its application to studies of development and inhibition. Molecular Microbiology, 52(4), 1187-1199. https://doi.org/10.1111/j.1365-2958.2004.04049.x

The ability to measure accurately comparative levels of protein expression after drug challenge, metabolic stress, developmental programming or other perturbation represents one of the most important goals in post-genomics malaria research. We descri... Read More about Quantitative proteomics of the human malaria parasite Plasmodium falciparum and its application to studies of development and inhibition.

Transcriptional analysis of genes encoding enzymes of the folate pathway in the human malaria parasite Plasmodium falciparum: Folate pathway transcription in malaria parasites (2002)
Journal Article
Nirmalan, N., Wang, P., Sims, P. F. G., & Hyde, J. E. (2002). Transcriptional analysis of genes encoding enzymes of the folate pathway in the human malaria parasite Plasmodium falciparum: Folate pathway transcription in malaria parasites. Molecular Microbiology, 46(1), 179-190. https://doi.org/10.1046/j.1365-2958.2002.03148.x

Folate metabolism in Plasmodium falciparum is essential for cell growth and replication, and the target of important antimalarial agents. The pathway comprises a series of enzymes that convert GTP to derivatives of tetrahydrofolate, which are cofacto... Read More about Transcriptional analysis of genes encoding enzymes of the folate pathway in the human malaria parasite Plasmodium falciparum: Folate pathway transcription in malaria parasites.

Evaluation of antimalarial chemotherapeutic practices and outcomes in the southwest region of Nigeria
Thesis
Akinsola, O. (in press). Evaluation of antimalarial chemotherapeutic practices and outcomes in the southwest region of Nigeria. (Thesis). University of Salford

With over 100 million cases of morbidity annually worldwide; control, elimination and eradication of malaria still remains a major challenge, particularly in sub-Saharan Africa. In some endemic countries, aggressive malaria control has reduced the ma... Read More about Evaluation of antimalarial chemotherapeutic practices and outcomes in the southwest region of Nigeria.

Investigating calcium channel blockers as antimalarials
Thesis
Rajab, M. (in press). Investigating calcium channel blockers as antimalarials. (Thesis). University of Salford

The rise in resistance to current antimalarial drugs has led researchers to consider drug repositioning as a quicker alternative for drug development and discovery. Preliminary drug repositioning screens carried out at the University of Salford ident... Read More about Investigating calcium channel blockers as antimalarials.

Drug repositioning as a route to anti-malarial drug discovery: preliminary investigation of the in vitro anti-malarial efficacy of emetine dihydrochloride hydrate
Journal Article
Matthews, H., Usman-Idris, M., Khan, F., Read, M., & Nirmalan, N. Drug repositioning as a route to anti-malarial drug discovery: preliminary investigation of the in vitro anti-malarial efficacy of emetine dihydrochloride hydrate. Malaria Journal, 12(1), 359. https://doi.org/10.1186/1475-2875-12-359

Background Drug repurposing or repositioning refers to the usage of existing drugs in diseases other than those it was originally used for. For diseases like malaria, where there is an urgent need for active drug candidates, the strategy offers a... Read More about Drug repositioning as a route to anti-malarial drug discovery: preliminary investigation of the in vitro anti-malarial efficacy of emetine dihydrochloride hydrate.