All Outputs (418)

Aquatic live animal radiotracing studies for ecotoxicological applications : addressing fundamental methodological deficiencies (2017)
Journal Article
Cresswell, T., Metian, M., Golding, L., & Wood, M. (2017). Aquatic live animal radiotracing studies for ecotoxicological applications : addressing fundamental methodological deficiencies. Journal of Environmental Radioactivity, 178-9, 453-460. https://doi.org/10.1016/j.jenvrad.2017.05.017

The use of live animal gamma radioisotope tracer techniques in the field of ecotoxicology allows laboratory studies to accurately monitor contaminant biokinetics in real time for an individual organism. However, methods used in published studies for... Read More about Aquatic live animal radiotracing studies for ecotoxicological applications : addressing fundamental methodological deficiencies.

Systolic [Ca2+ ]i regulates diastolic levels in rat ventricular myocytes (2017)
Journal Article
Sankaranarayanan, R., Kistamas, K., Greensmith, D., Venetucci, L., & Eisner, D. (2017). Systolic [Ca2+ ]i regulates diastolic levels in rat ventricular myocytes. Journal of Physiology, 595(16), 5545-5555. https://doi.org/10.1113/JP274366

[Ca2+]i must be low enough in diastole so that the ventricle is relaxed and can refill with blood. Interference with this will impair relaxation. The factors responsible for regulation of diastolic [Ca2+]i, in particular the relative roles of the sar... Read More about Systolic [Ca2+ ]i regulates diastolic levels in rat ventricular myocytes.

Domestic building fabric performance : closing the gap between the in situ measured and modelled performance (2017)
Journal Article
Marshall, A., Fitton, R., Swan, W., Farmer, D., Johnston, D., Benjaber, M., & Ji, Y. (2017). Domestic building fabric performance : closing the gap between the in situ measured and modelled performance. Energy and Buildings, 150, 307-317. https://doi.org/10.1016/j.enbuild.2017.06.028

There is a growing body of evidence available to indicate that there is often a discrepancy between the in situ measured thermal performance of a building fabric and the steady-state predicted performance of that fabric, even when the building fabric... Read More about Domestic building fabric performance : closing the gap between the in situ measured and modelled performance.

Computer modelling of electro-osmotically augmented three-layered microvascular peristaltic blood flow (2017)
Journal Article
Tripathi, D., Borode, A., Jhorar, R., Beg, O., & Tiwari, A. (2017). Computer modelling of electro-osmotically augmented three-layered microvascular peristaltic blood flow. Microvascular Research, 114, 65-83. https://doi.org/10.1016/j.mvr.2017.06.004

A theoretical study is presented here for the electro-osmosis modulated peristaltic three-layered capillary flow of viscous fluids with different viscosities in the layers. The layers considered here are the core layer, the intermediate layer and the... Read More about Computer modelling of electro-osmotically augmented three-layered microvascular peristaltic blood flow.

Targeting hypoxic cancer stem cells (CSCs) with Doxycycline : implications for optimizing anti-angiogenic therapy (2017)
Journal Article
implications for optimizing anti-angiogenic therapy. Oncotarget, 2017(8), 56126-56142. https://doi.org/10.18632/oncotarget.18445

Here, we report new mechanistic insight into how chronic hypoxia increases ‘stemness’ in cancer cells. Using chemical inhibitors, we provide direct experimental evidence that ROS production and mitochondrial biogenesis are both required for the hypox... Read More about Targeting hypoxic cancer stem cells (CSCs) with Doxycycline : implications for optimizing anti-angiogenic therapy.

Built asset management climate change adaptation model (2017)
Journal Article
Jones, K., Desai, A., Brosnan, N., Cooper, J., & Ali, F. (2017). Built asset management climate change adaptation model. International Journal of Disaster Resilience in the Built Environment, 8(3), 263-274. https://doi.org/10.1108/IJDRBE-07-2016-0032

Climate change continues to pose major challenges to those responsible for the management of built assets. Whilst mitigation is largely being driven by legislation and corporate social responsibility, adaptation has to compete alongside general built... Read More about Built asset management climate change adaptation model.

A wheelchair control system using human-machine interaction: single-modal and multimodal approaches (2017)
Journal Article
Shahin, M., Tharwat, A., Gaber, T., & Hassanien, A. (2017). A wheelchair control system using human-machine interaction: single-modal and multimodal approaches. Journal of Intelligent Systems, 28(1), https://doi.org/10.1515/jisys-2017-0085

Recent research studies showed that brain-controlled systems/devices are breakthrough technology. Such devices can provide disabled people with the power to control the movement of the wheelchair using different signals (e.g. EEG signals, head moveme... Read More about A wheelchair control system using human-machine interaction: single-modal and multimodal approaches.

Clang, chitter, crunch : perceptual organisation of onomatopoeia (2017)
Journal Article
Bones, O., Davies, W., & Cox, T. (2017). Clang, chitter, crunch : perceptual organisation of onomatopoeia. ˜The œJournal of the Acoustical Society of America (Online), 141(5), 3694-3694. https://doi.org/10.1121/1.4988048

A method has been developed that utilizes a sound-sorting and labeling procedure, with correspondence analysis of participant-generated descriptive terms, to elicit perceptual categories of sound. Unlike many other methods for identifying perceptual... Read More about Clang, chitter, crunch : perceptual organisation of onomatopoeia.

A user-centered taxonomy of factors contributing to the listener experience of reproduced audio (2017)
Journal Article
Woodcock, J., Davies, W., & Cox, T. (2017). A user-centered taxonomy of factors contributing to the listener experience of reproduced audio. ˜The œJournal of the Acoustical Society of America (Online), 141(5), 3464-3464. https://doi.org/10.1121/1.4987193

The traditional paradigm for the assessment of audio quality is that of a listener positioned in the geometric center of a standardized loudspeaker setup, fully attending to the reproduced sound scene. However, this is not how listeners generally int... Read More about A user-centered taxonomy of factors contributing to the listener experience of reproduced audio.

Deregulation of miRNAs in malignant pleural mesothelioma is associated with prognosis and suggests an alteration of cell metabolism (2017)
Journal Article
De Santi, C., Melaiu, O., Bonotti, A., Cascione, L., Di Leva, G., Foddis, R., …Landi, S. (2017). Deregulation of miRNAs in malignant pleural mesothelioma is associated with prognosis and suggests an alteration of cell metabolism. Scientific reports, 7(2017), #3140. https://doi.org/10.1038/s41598-017-02694-0

Malignant pleural mesothelioma (MPM) is an aggressive human cancer and miRNAs can play a key-role for this disease. In order to broaden the knowledge in this field, the miRNA expression was investigated in a large series of MPM to discover new pathwa... Read More about Deregulation of miRNAs in malignant pleural mesothelioma is associated with prognosis and suggests an alteration of cell metabolism.

Evaluation of the impact of 2 years of a dosing intervention on canine echinococcosis in the Alay Valley, Kyrgyzstan (2017)
Journal Article
van Kesteren, F., Mastin, A., Torgerson, P., Mytynova, B., & Craig, P. (2017). Evaluation of the impact of 2 years of a dosing intervention on canine echinococcosis in the Alay Valley, Kyrgyzstan. Parasitology, 144(10), 1328-1337. https://doi.org/10.1017/S0031182017000397

Echinococcosis is a re-emerging zoonotic disease in Kyrgyzstan. In 2012, an echinococcosis control scheme was started that included dosing owned dogs in the Alay Valley, Kyrgyzstan with praziquantel. Control programmes require large investments of mo... Read More about Evaluation of the impact of 2 years of a dosing intervention on canine echinococcosis in the Alay Valley, Kyrgyzstan.

Vitamin C and Doxycycline : a synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs) (2017)
Journal Article
De Francesco, E., Bonuccelli, G., Maggiolini, M., Sotgia, F., & Lisanti, M. (2017). Vitamin C and Doxycycline : a synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs). Oncotarget, 2017(8), 67269-67286. https://doi.org/10.18632/oncotarget.18428

Here, we developed a new synthetic lethal strategy for further optimizing the eradication of cancer stem cells (CSCs). Briefly, we show that chronic treatment with the FDA-approved antibiotic Doxycycline effectively reduces cellular respiration, by... Read More about Vitamin C and Doxycycline : a synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs).

Influence of source location and temporal structure on spatial auditory saliency (2017)
Journal Article
Podwinska, Z., Fazenda, B., & Davies, W. (2017). Influence of source location and temporal structure on spatial auditory saliency. ˜The œJournal of the Acoustical Society of America (Online), 141(5), 3639-3639. https://doi.org/10.1121/1.4987852

Hitherto, not many studies have dealt with spatial auditory saliency. Auditory attention studies concerned with spatial aspects generally concentrate on top-down selective or divided attention, e.g., where subjects are asked to attend to one source a... Read More about Influence of source location and temporal structure on spatial auditory saliency.

Differences in sound perception are reflected by individual auditory fingerprints in musicians (2017)
Journal Article
Benner, J., Reinhardt, J., Hofmann, E., Stippich, C., Schneider, P., Blatow, M., & Davies, W. (2017). Differences in sound perception are reflected by individual auditory fingerprints in musicians. ˜The œJournal of the Acoustical Society of America (Online), 141(5), 3818-3818. https://doi.org/10.1121/1.4988456

Musicians have been reported to show significant inter-Individual differences in elementary hearing functions, sound perception mode, musical instrument preference, performance style, as well as more complex musical abilities like absolute- and relat... Read More about Differences in sound perception are reflected by individual auditory fingerprints in musicians.

Ecosystem services of collectively managed urban gardens : exploring factors affecting synergies and trade-offs at the site level (2017)
Journal Article
Dennis, M., & James, P. (2017). Ecosystem services of collectively managed urban gardens : exploring factors affecting synergies and trade-offs at the site level. Ecosystem Services, 26(A), 17-26. https://doi.org/10.1016/j.ecoser.2017.05.009

Collective management of urban green space is being acknowledged and promoted. The need to understand productivity and potential trade-offs between co-occurring ecosystem services arising from collectively managed pockets of green space is pivotal to... Read More about Ecosystem services of collectively managed urban gardens : exploring factors affecting synergies and trade-offs at the site level.

Outdoor thermal comfort by different heat mitigation strategies - a review (2017)
Journal Article
Taleghani, M. (2017). Outdoor thermal comfort by different heat mitigation strategies - a review. Renewable and Sustainable Energy Reviews, 81(2), 2011-2018. https://doi.org/10.1016/j.rser.2017.06.010

Due to the ongoing global warming, heat mitigation strategies are becoming implemented through practice and simulations. These efforts aim to make the cities that are dealing with the urban heat island more livable. The effect of heat mitigation str... Read More about Outdoor thermal comfort by different heat mitigation strategies - a review.

Galloping of an elliptical cylinder at the critical Reynolds number and its quasi-steady prediction (2017)
Journal Article
Ma, W., Macdonald, J., Liu, Q., Nguyen, C., & Liu, X. (2017). Galloping of an elliptical cylinder at the critical Reynolds number and its quasi-steady prediction. Journal of Wind Engineering and Industrial Aerodynamics, 168, 110-122. https://doi.org/10.1016/j.jweia.2017.04.022

Dry galloping of inclined cables has been shown to have a strong relation to the critical Reynolds number. This study considers the occurrence of galloping of an elliptical cylinder at the critical Reynolds number under normal wind and assesses the q... Read More about Galloping of an elliptical cylinder at the critical Reynolds number and its quasi-steady prediction.

The trouble with temporary : impacts and pitfalls of a meanwhile community garden in Wythenshawe, South Manchester (2017)
Journal Article
St Clair, R., Hardman, M., Armitage, R., & Sherriff, G. (2017). The trouble with temporary : impacts and pitfalls of a meanwhile community garden in Wythenshawe, South Manchester. Renewable Agriculture and Food Systems, 33(6), 548-557. https://doi.org/10.1017/S1742170517000291

The rise of Urban Agriculture projects across the UK has led to a surge of interest in their efficacy and resulting social impacts. Real Food Wythenshawe is a Lottery-funded urban food project in the UK that aims to teach the population of Wythensh... Read More about The trouble with temporary : impacts and pitfalls of a meanwhile community garden in Wythenshawe, South Manchester.

Broadband cooling spectra of hot electrons and holes in PbSe quantum dots (2017)
Journal Article
Spoor, F., Tomic, S., Houtepen, A., & Siebbeles, L. (2017). Broadband cooling spectra of hot electrons and holes in PbSe quantum dots. ACS nano, 11(6), 6286-6294. https://doi.org/10.1021/acsnano.7b02506

Understanding cooling of hot charge carriers in semiconductor quantum dots (QDs) is of fundamental interest and useful to enhance the performance of QDs in photovoltaics. We study electron and hole cooling dynamics in PbSe QDs up to high energies whe... Read More about Broadband cooling spectra of hot electrons and holes in PbSe quantum dots.

Differential regulation of cell death pathways by the microenvironment correlates with chemoresistance and survival in leukaemia (2017)
Journal Article
Qattan, M., Bakker, E., Rajendran, R., Wei-Chen Chen, D., Saha, V., Liu, J., …Krstic- Demonacos, M. (2017). Differential regulation of cell death pathways by the microenvironment correlates with chemoresistance and survival in leukaemia. PLoS ONE, 12(6), e0178606. https://doi.org/10.1371/journal.pone.0178606

Glucocorticoids (GCs) and topoisomerase II inhibitors are used to treat acute lymphoblastic leukaemia (ALL) as they induce death in lymphoid cells through the glucocorticoid receptor (GR) and p53 respectively. Mechanisms underlying ALL cell death and... Read More about Differential regulation of cell death pathways by the microenvironment correlates with chemoresistance and survival in leukaemia.