Skip to main content

Research Repository

Advanced Search

All Outputs (6205)

Functional genomic hypothesis generation and experimentation by a robot scientist (2004)
Journal Article
King, R., Whelan, K., Jones, F., Reiser, P., Bryant, C., Muggleton, S., …Oliver, S. (2004). Functional genomic hypothesis generation and experimentation by a robot scientist. Nature, 427(6971), 247-252. https://doi.org/10.1038/nature02236

The question of whether it is possible to automate the scientific process is of both great theoretical interest and increasing practical importance because, in many scientific areas, data are being generated much faster than they can be effectively a... Read More about Functional genomic hypothesis generation and experimentation by a robot scientist.

Conformational analysis with both experimental and computational data for both gaseous and crystalline phases: unexpected interactions in N-methyldichloroacetamide (2004)
Journal Article
Hinchley, S., Robertson, H., McLachlan, L., Morrison, C., Rankin, D., Simpson, S., & Thomas, E. (2004). Conformational analysis with both experimental and computational data for both gaseous and crystalline phases: unexpected interactions in N-methyldichloroacetamide. https://doi.org/10.1021/jp036478h

The structure of N-methyldichloroacetamide (MeNHCOCHCl2) has been elucidated in the gaseous and solid states experimentally by gas electron diffraction and X-ray crystallography, and computationally with ab initio and plane-wave DFT methods. Although... Read More about Conformational analysis with both experimental and computational data for both gaseous and crystalline phases: unexpected interactions in N-methyldichloroacetamide.

Diblock polyampholytes grafted onto spherical particles : Monte Carlo simulation and lattice mean-field theory (2004)
Journal Article
Akinchina, A., Shusharina, N., & Linse, P. (2004). Diblock polyampholytes grafted onto spherical particles : Monte Carlo simulation and lattice mean-field theory. Langmuir, 20(23), 10351-10360. https://doi.org/10.1021/la0490386

Spherical brushes composed of diblock polyampholytes (diblock copolymers with oppositely charged blocks) grafted onto solid spherical particles in aqueous solution are investigated by using the primitive model solved with Monte Carlo simulations an... Read More about Diblock polyampholytes grafted onto spherical particles : Monte Carlo simulation and lattice mean-field theory.

Technology‐based learning and the project manager (2004)
Journal Article
Ellis, R., Wood, G., & Thorpe, T. (2004). Technology‐based learning and the project manager. Engineering, Construction and Architectural Management, 11(5), 358-365. https://doi.org/10.1108/09699980410558557

Construction is a project‐oriented industry that benefits from both the technical and interpersonal skills that a project manager has to offer. Increasingly, project management is viewed as being an integrated process relevant throughout the project... Read More about Technology‐based learning and the project manager.

Exact analytical helmholtz bright and dark solitons (2004)
Journal Article
Chamorro-Posada, P., & McDonald, G. (2004). Exact analytical helmholtz bright and dark solitons. Proceedings of SPIE, 5582, 154. https://doi.org/10.1117/12.583404

In this paper, exact analytical Helmholtz bright and dark soliton solutions for a Kerr nonlinearity are presented. Numerical simulations verify that these solutions are both robust and act as attractors in nonlinear beam dynamics. Results dealing wit... Read More about Exact analytical helmholtz bright and dark solitons.

The major human AP endonuclease (Ape1) is involved in the nucleotide incision repair pathway (2004)
Journal Article
Gros, L., Ishchenko, A., Ide, H., Elder, R., & Saparbaev, M. (2004). The major human AP endonuclease (Ape1) is involved in the nucleotide incision repair pathway. Nucleic Acids Research, 32(1), 73-81. https://doi.org/10.1093/nar/gkh165

In nucleotide incision repair (NIR), an endonuclease nicks oxidatively damaged DNA in a DNA glycosylase-independent manner, providing the correct ends for DNA synthesis coupled to the repair of the remaining 5'-dangling modified nucleotide. This mech... Read More about The major human AP endonuclease (Ape1) is involved in the nucleotide incision repair pathway.

Universities, regional policy and the knowledge economy (2004)
Journal Article
May, T., & Peters, M. (2004). Universities, regional policy and the knowledge economy. Policy Futures in Education, 2(2), 263-277. https://doi.org/10.2304/pfie.2004.2.2.4

This article focuses on the spatial clustering dimension of new information and communications technology (ICT)-driven economic activity based on knowledge industries and especially the tacit knowledge synergies to be achieved through networking in g... Read More about Universities, regional policy and the knowledge economy.

Late prehistoric and Romano-British settlement of the Mersey Basin (2004)
Journal Article
Nevell, M. (2004). Late prehistoric and Romano-British settlement of the Mersey Basin. Journal of the Chester Archaeological Society, 78, 1-21

This paper presents an overview of some recent attempts to provide a theoretical framework for both the location and interpretation of the growing number of late prehistoric and Romano-Bitish rural sites within the region centred around the theme of... Read More about Late prehistoric and Romano-British settlement of the Mersey Basin.

Pilot plant study for one year: Water quality management and algal control of sustainable urban stormwater ponds (2004)
Journal Article
Scholz, M. (2004). Pilot plant study for one year: Water quality management and algal control of sustainable urban stormwater ponds. International Journal of Water, 2(4), 312-330. https://doi.org/10.1504/IJW.2004.005529

Pond structures as cost-effective ''source control'' drainage techniques that can be applied to reduce the risk of downstream flooding and to recycle stormwater. There are no widely accepted performance and water quality management data on stormwater... Read More about Pilot plant study for one year: Water quality management and algal control of sustainable urban stormwater ponds.

Stormwater quality associated with a silt trap (empty and full) discharging into an urban watercourse in Scotland (2004)
Journal Article
Scholz, M. (2004). Stormwater quality associated with a silt trap (empty and full) discharging into an urban watercourse in Scotland. International Journal of Environmental Studies, 61(4), 471-483. https://doi.org/10.1080/0020723042000212681

The aim was to assess the influence of a full silt trap at the end of a stormwater drainage pipe on the water quality of stormwater discharged into a semi‐natural urban watercourse. For approximately eleven weeks, the water qualities of the prelimina... Read More about Stormwater quality associated with a silt trap (empty and full) discharging into an urban watercourse in Scotland.

Effect of TA-CIN (HPV 16 L2E6E7) booster immunisation in vulval intraepithelial neoplasia patients previously vaccinated with TA-HPV (vaccinia virus encoding HPV 16/18 E6E7) (2004)
Journal Article
Davidson, E., Faulkner, R., Sehr, P., Pawlita, M., Smyth, L., Burt, D., …Stern, P. (2004). Effect of TA-CIN (HPV 16 L2E6E7) booster immunisation in vulval intraepithelial neoplasia patients previously vaccinated with TA-HPV (vaccinia virus encoding HPV 16/18 E6E7). Vaccine, 22(21-22), 2722-2729. https://doi.org/10.1016/j.vaccine.2004.01.049

Heterologous prime-boost vaccination schedules employing TA-HPV, a vaccinia virus encoding HPV 16/18 E6 and E7, in combination with TA-CIN, an HPV 16 L2E6E7 fusion protein, may offer advantages over the use of either agent alone for the immunotherapy... Read More about Effect of TA-CIN (HPV 16 L2E6E7) booster immunisation in vulval intraepithelial neoplasia patients previously vaccinated with TA-HPV (vaccinia virus encoding HPV 16/18 E6E7).

Immunological responses in women with human Papillomavirus Type 16 (HPV-16)-associated anogenital intraepithelial neoplasia induced by heterologous prime-boost HPV-16 oncogene vaccination (2004)
Journal Article
Smyth, L., Van Poelgeest, M., Davidson, E., Kwappenberg, K., Burt, D., Sehr, P., …Van Der Burg, S. (2004). Immunological responses in women with human Papillomavirus Type 16 (HPV-16)-associated anogenital intraepithelial neoplasia induced by heterologous prime-boost HPV-16 oncogene vaccination. Clinical Cancer Research, 10(9), 2954. https://doi.org/10.1158/1078-0432.CCR-03-0703

Purpose: The purpose is to study the immunogenicity of heterologous prime-boost human papillomavirus (HPV) oncogene vaccination in patients with anogenital intraepithelial neoplasia (AGIN). Experimental Design: Twenty-nine women with high-grade AG... Read More about Immunological responses in women with human Papillomavirus Type 16 (HPV-16)-associated anogenital intraepithelial neoplasia induced by heterologous prime-boost HPV-16 oncogene vaccination.

Application of artificical neural network in complex systems of regional sustainable development (2004)
Journal Article
Shi, C., Guo, Z., & James, P. (2004). Application of artificical neural network in complex systems of regional sustainable development. Chinese Geographical Science, 14(1), 1-8. https://doi.org/10.1007/s11769-004-0001-7

Meeting the challenge of sustainable development requires substantial advances in understanding the interaction of natural and human systems. The dynamics of regional sustainable development could be addressed in the context of complex system thinkin... Read More about Application of artificical neural network in complex systems of regional sustainable development.

The abundance of premetamorphic newts (triturus cristatus, t. marmoratus) as a function of habitat determinants: an a priori model selection approach (2004)
Journal Article
model selection approach. Herpetological journal, 14, 89-97

Despite the key role of premetamorphic amphibians in experimental ecology, the factors affecting their abundance has received relatively little attention in natural settings. We applied a model selection approach with AIC (Akaike's Information Crit... Read More about The abundance of premetamorphic newts (triturus cristatus, t. marmoratus) as a function of habitat determinants: an a priori model selection approach.

Cost comparison of marking techniques in long-term population studies: PIT-tags versus pattern maps (2004)
Journal Article
Arntzen, J., Goudie, I., Halley, J., & Jehle, R. (2004). Cost comparison of marking techniques in long-term population studies: PIT-tags versus pattern maps. Amphibia-Reptilia, 25(3), 305-315. https://doi.org/10.1163/1568538041975116

Conservation biology requires the assessment of demographic parameters and life-history data in wildlife populations. Such data can be gathered through capture-mark-recapture (CMR) of individuals. Marking techniques may vary for study organisms, rese... Read More about Cost comparison of marking techniques in long-term population studies: PIT-tags versus pattern maps.