Studies on the effect of asparaginase in paediatric leukaemia
(2010)
Thesis
Coe, N. Studies on the effect of asparaginase in paediatric leukaemia. (Thesis). Salford : University of Salford
Asparaginase, an important agent in the treatment of acute lymphoblastic
leukaemia, is thought to cause cell death by depriving lymphoblasts of
asparagine. However, because asparaginase also hydrolyses glutamine,
a critical fuel for normal lymphoc...
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