Synthesis and evaluation of novel kinase inhibitors as anti-cancer agents
(2012)
Thesis
Kemp, T. Synthesis and evaluation of novel kinase inhibitors as anti-cancer agents. (Thesis). University of Salford
Disruption of protein kinase signalling pathways is often associated with cancer. The
RhoA/ROCK kinase pathway has been shown to be constitutively expressed in many cancers
and has also been shown to be involved in metastasis and apoptosis. ROCK is...
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