Synthesis of a simplified analogue of eleutherobin via a Claisen rearrangement and ring closing metathesis strategy
(2005)
Journal Article
Chiang, G., Ayscough, A., Bond, A., Pain, G., Ducki, S., & Holmes, A. (2005). Synthesis of a simplified analogue of eleutherobin via a Claisen rearrangement and ring closing metathesis strategy. Chemical Communications, 1860-1862. https://doi.org/10.1039/b413426e
The enantioselective synthesis of a simplified eleutherobin analogue by ring closing metathesis (RCM) of the 2,9-divinyl-substituted tetrahydro-oxonin is described; the analogue and an advanced intermediate revealed microtubule stabilising properties... Read More about Synthesis of a simplified analogue of eleutherobin via a Claisen rearrangement and ring closing metathesis strategy.