All Outputs (33)

Improving competency in safe patient handling practice through online learning beyond the classroom – a longitudinal study (2022)
Journal Article
Webb, J., Hogg, P., Twiste, M., & Correa, E. (2022). Improving competency in safe patient handling practice through online learning beyond the classroom – a longitudinal study. American Journal of Occupational Therapy, 76(2), 7602205160. https://doi.org/10.5014/ajot.2022.044388

Importance Safe patient handling is intrinsic to healthcare provision; yet, educational provision of the skills for this are inconsistently delivered, without evidence that traditional face-to-face training reduces risk. Objective This study asse... Read More about Improving competency in safe patient handling practice through online learning beyond the classroom – a longitudinal study.

The integration of artificial intelligence models to augment imaging modalities in pancreatic cancer (2020)
Journal Article
Wang, X., Chung, W., Correa, E., Zhu, Y., Issa, E., & Dennison, A. (2020). The integration of artificial intelligence models to augment imaging modalities in pancreatic cancer. Journal of Pancreatology, 3(4), 173-180. https://doi.org/10.1097/JP9.0000000000000056

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a limited number of effective treatments. Using emerging technologies such as artificial intelligence (AI) to facilitate the earlier diagnosis and decision-making process repres... Read More about The integration of artificial intelligence models to augment imaging modalities in pancreatic cancer.

Using probe electrospray ionization mass spectrometry and machine learning for detecting pancreatic cancer with high performance (2020)
Journal Article
Chung, W., Correa, E., Yoshimura, K., Chang, M., Dennison, A., Takeda, S., & Chang, Y. (2020). Using probe electrospray ionization mass spectrometry and machine learning for detecting pancreatic cancer with high performance. American Journal of Translational Research, 12(1), 171-179

A rapid blood-based diagnostic modality to detect pancreatic ductal adenocarcinoma (PDAC) with high accuracy is an unmet medical need. The study aimed to validate a unique diagnosis system using Probe Electrospray Ionization Mass Spectrometry (PESI-M... Read More about Using probe electrospray ionization mass spectrometry and machine learning for detecting pancreatic cancer with high performance.

pH plays a role in the mode of action of trimethoprim on Escherichia coli (2018)
Journal Article
AlRabiah, H., Allwood, J., Correa, E., Xu, Y., & Goodacre, R. (2018). pH plays a role in the mode of action of trimethoprim on Escherichia coli. PLoS ONE, 13(7), e0200272. https://doi.org/10.1371/journal.pone.0200272

Metabolomics-based approaches were applied to understand interactions of trimethoprim with Escherichia coli K-12 at sub-minimum inhibitory concentrations (MIC≈0.2, 0.03 and 0.003 mg L-1). Trimethoprim inhibits dihydrofolate reductase and thereby is a... Read More about pH plays a role in the mode of action of trimethoprim on Escherichia coli.

Detection of glycosylation and iron-binding protein modifications using Raman spectroscopy (2017)
Journal Article
Ashton, L., Brewster, V., Correa, E., & Goodacre, R. (2017). Detection of glycosylation and iron-binding protein modifications using Raman spectroscopy. Analyst, 5, https://doi.org/10.1039/C6AN02516A

In this study we demonstrate the use of Raman spectroscopy to determine protein modifications as a result of glycosylation and iron binding. Most proteins undergo some modifications after translation which can directly affect protein function. Identi... Read More about Detection of glycosylation and iron-binding protein modifications using Raman spectroscopy.

Changes in prevalence of obesity and high waist circumference over four years across European regions: the European male ageing study (EMAS) (2016)
Journal Article
Han, T., Correa, E., Lean, M., Lee, D., O’Neill, T., Bartfai, G., …Casanueva, F. (2017). Changes in prevalence of obesity and high waist circumference over four years across European regions: the European male ageing study (EMAS). Endocrine, 55(2), 456-469. https://doi.org/10.1007/s12020-016-1135-y

Diversity in lifestyles and socioeconomic status among European populations, and recent socio-political and economic changes in transitional countries, may affect changes in adiposity. We aimed to determine whether change in the prevalence of obesity... Read More about Changes in prevalence of obesity and high waist circumference over four years across European regions: the European male ageing study (EMAS).

Evaluation of cognitive subdomains, 25-hydroxyvitamin D, and 1,25-dihydroxyvitamin D in the European Male Ageing Study (2016)
Journal Article
Overman, M., Pendleton, N., O’Neill, T., Bartfai, G., Casanueva, F., Finn, J., …Tournoy, J. (2016). Evaluation of cognitive subdomains, 25-hydroxyvitamin D, and 1,25-dihydroxyvitamin D in the European Male Ageing Study. European Journal of Nutrition, 56(6), 2093-2103. https://doi.org/10.1007/s00394-016-1247-4

PURPOSE: Although lower levels of vitamin D have been related to poor cognitive functioning and dementia in older adults, evidence from longitudinal investigations is inconsistent. The objective of this study was to determine whether 25-hydroxyvita... Read More about Evaluation of cognitive subdomains, 25-hydroxyvitamin D, and 1,25-dihydroxyvitamin D in the European Male Ageing Study.

Fractional Factorial Design of MALDI-TOF-MS Sample Preparations for the Optimized Detection of Phospholipids and Acylglycerols (2016)
Journal Article
AlMasoud, N., Correa, E., Trivedi, D., & Goodacre, R. (2016). Fractional Factorial Design of MALDI-TOF-MS Sample Preparations for the Optimized Detection of Phospholipids and Acylglycerols. Analytical Chemistry, 88(12), 6301-6308. https://doi.org/10.1021/acs.analchem.6b00512

Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS) has successfully been used for the analysis of high molecular weight compounds, such as proteins and nucleic acids. By contrast, analysis of low molecular wei... Read More about Fractional Factorial Design of MALDI-TOF-MS Sample Preparations for the Optimized Detection of Phospholipids and Acylglycerols.

Data standards can boost metabolomics research, and if there is a will, there is a way (2015)
Journal Article
Rocca-Serra, P., Salek, R., Arita, M., Correa, E., Dayalan, S., Gonzalez-Beltran, A., …Neumann, S. (2016). Data standards can boost metabolomics research, and if there is a will, there is a way. Metabolomics, 12(1), https://doi.org/10.1007/s11306-015-0879-3

Thousands of articles using metabolomics approaches are published every year. With the increasing amounts of data being produced, mere description of investigations as text in manuscripts is not sufficient to enable re-use anymore: the underlying dat... Read More about Data standards can boost metabolomics research, and if there is a will, there is a way.

PWE-200 Metabolomic profiling in pancreatic cancer; in search of new biomarkers (2015)
Journal Article
Ross, N., Correa, E., Rattray, N., Hildebrand, D., Xu, Y., Trivedi, D., …Watson, A. (2015). PWE-200 Metabolomic profiling in pancreatic cancer; in search of new biomarkers. Gut, 64(Suppl), A300.1-A300. https://doi.org/10.1136/gutjnl-2015-309861.647

Introduction Pancreatic cancer is a devastating disease with a poor outcome. Current biomarkers fall short in accessibility, sensitivity, specificity and their ability to distinguish malignant from benign conditions. Metabolomics aims to decipher mol... Read More about PWE-200 Metabolomic profiling in pancreatic cancer; in search of new biomarkers.

Phenotypic Characterisation of Shewanella oneidensis MR-1 Exposed to X-Radiation (2015)
Journal Article
Senko, J., Brown, A., Correa, E., Xu, Y., AlMasoud, N., Pimblott, S., …Lloyd, J. (2015). Phenotypic Characterisation of Shewanella oneidensis MR-1 Exposed to X-Radiation. PLoS ONE, 10(6), e0131249. https://doi.org/10.1371/journal.pone.0131249

Biogeochemical processes mediated by Fe(III)-reducing bacteria such as Shewanella oneidensis have the potential to influence the post-closure evolution of a geological disposal facility for radioactive wastes and to affect the solubility of some radi... Read More about Phenotypic Characterisation of Shewanella oneidensis MR-1 Exposed to X-Radiation.

PTU-093 Metabolomic profiling in inflammatory bowel disease (2015)
Journal Article
Hildebrand, D., Trivedi, D., Xu, Y., Rattray, N., Ross, N., Correa, E., …Watson, A. (2015). PTU-093 Metabolomic profiling in inflammatory bowel disease. Gut, 64(Suppl), A102.1-A102. https://doi.org/10.1136/gutjnl-2015-309861.208

Introduction Inflammatory bowel disease is classified into 2 main types; Crohn’s disease (CD) and ulcerative colitis (UC). Differentiation can prove clinically challenging. Metabolomic profiling is an emerging science that is utilised for biomarker d... Read More about PTU-093 Metabolomic profiling in inflammatory bowel disease.

PWE-199 Metabolomic profiling in acute pancreatitis; in search of new biomarkers (2015)
Journal Article
Ross, N., Correa, E., Rattray, N., Hildebrand, D., Trivedi, D., Goodacre, R., & Watson, A. (2015). PWE-199 Metabolomic profiling in acute pancreatitis; in search of new biomarkers. Gut, 64(Suppl), A299.2-A300. https://doi.org/10.1136/gutjnl-2015-309861.646

Introduction Severe acute pancreatitis (AP) carries a 30–50% mortality.1Current scoring systems fall short in predictive accuracy, sensitivity, specificity and availability.2Metabolomics aims to decipher molecular signatures that will distinguish dis... Read More about PWE-199 Metabolomic profiling in acute pancreatitis; in search of new biomarkers.

COordination of Standards in MetabOlomicS (COSMOS): facilitating integrated metabolomics data access (2015)
Journal Article
Salek, R., Neumann, S., Schober, D., Hummel, J., Billiau, K., Kopka, J., …Steinbeck, C. (2015). COordination of Standards in MetabOlomicS (COSMOS): facilitating integrated metabolomics data access. Metabolomics, 11(6), 1587-1597. https://doi.org/10.1007/s11306-015-0810-y

Metabolomics has become a crucial phenotyping technique in a range of research fields including medicine, the life sciences, biotechnology and the environmental sciences. This necessitates the transfer of experimental information between research gro... Read More about COordination of Standards in MetabOlomicS (COSMOS): facilitating integrated metabolomics data access.

Metabolic Profiling of Geobacter sulfurreducens during Industrial Bioprocess Scale-Up (2015)
Journal Article
Muhamadali, H., Xu, Y., Ellis, D., Allwood, J., Rattray, N., Correa, E., …Löffler, F. (2015). Metabolic Profiling of Geobacter sulfurreducens during Industrial Bioprocess Scale-Up. Applied and Environmental Microbiology, 81(10), 3288-3298. https://doi.org/10.1128/AEM.00294-15

During the industrial scale-up of bioprocesses it is important to establish that the biological system has not changed significantly when moving from small laboratory-scale shake flasks or culturing bottles to an industrially relevant production leve... Read More about Metabolic Profiling of Geobacter sulfurreducens during Industrial Bioprocess Scale-Up.

Oxidized phosphatidylcholines suggest oxidative stress in patients with medium-chain acyl-CoA dehydrogenase deficiency (2015)
Journal Article
Najdekr, L., Gardlo, A., Mádrová, L., Friedecký, D., Janečková, H., Correa, E., …Adam, T. (2015). Oxidized phosphatidylcholines suggest oxidative stress in patients with medium-chain acyl-CoA dehydrogenase deficiency. Talanta, 139, 62-66. https://doi.org/10.1016/j.talanta.2015.02.041

Inborn errors of metabolism encompass a large group of diseases caused by enzyme deficiencies and are therefore amenable to metabolomics investigations. Medium chain acyl-CoA dehydrogenase deficiency (MCADD) is a defect in β-oxidation of fatty acids,... Read More about Oxidized phosphatidylcholines suggest oxidative stress in patients with medium-chain acyl-CoA dehydrogenase deficiency.

Profiling of spatial metabolite distributions in wheat leaves under normal and nitrate limiting conditions (2015)
Journal Article
Allwood, J., Chandra, S., Xu, Y., Dunn, W., Correa, E., Hopkins, L., …Bowsher, C. (2015). Profiling of spatial metabolite distributions in wheat leaves under normal and nitrate limiting conditions. Phytochemistry, 115, 99-111. https://doi.org/10.1016/j.phytochem.2015.01.007

The control and interaction between nitrogen and carbon assimilatory pathways is essential in both photosynthetic and non-photosynthetic tissue in order to support metabolic processes without compromising growth. Physiological differences between the... Read More about Profiling of spatial metabolite distributions in wheat leaves under normal and nitrate limiting conditions.

A tutorial review: Metabolomics and partial least squares-discriminant analysis – a marriage of convenience or a shotgun wedding (2015)
Journal Article
Gromski, P., Muhamadali, H., Ellis, D., Xu, Y., Correa, E., Turner, M., & Goodacre, R. (2015). A tutorial review: Metabolomics and partial least squares-discriminant analysis – a marriage of convenience or a shotgun wedding. Analytica Chimica Acta, 879, 10-23. https://doi.org/10.1016/j.aca.2015.02.012

The predominance of partial least squares-discriminant analysis (PLS-DA) used to analyze metabolomics datasets (indeed, it is the most well-known tool to perform classification and regression in metabolomics), can be said to have led to the point tha... Read More about A tutorial review: Metabolomics and partial least squares-discriminant analysis – a marriage of convenience or a shotgun wedding.

A comparison of different chemometrics approaches for the robust classification of electronic nose data (2014)
Journal Article
Gromski, P., Correa, E., Vaughan, A., Wedge, D., Turner, M., & Goodacre, R. (2014). A comparison of different chemometrics approaches for the robust classification of electronic nose data. Analytical and Bioanalytical Chemistry, 406(29), 7581-7590. https://doi.org/10.1007/s00216-014-8216-7

Accurate detection of certain chemical vapours is important, as these may be diagnostic for the presence of weapons, drugs of misuse or disease. In order to achieve this, chemical sensors could be deployed remotely. However, the readout from such sen... Read More about A comparison of different chemometrics approaches for the robust classification of electronic nose data.

Influence of missing values substitutes on multivariate analysis of metabolomics data (2014)
Journal Article
Gromski, P., Xu, Y., Kotze, H., Correa, E., Ellis, D., Armitage, E., …Goodacre, R. (2014). Influence of missing values substitutes on multivariate analysis of metabolomics data. Metabolites, 4(2), 433-452. https://doi.org/10.3390/metabo4020433

Missing values are known to be problematic for the analysis of gas chromatography-mass spectrometry (GC-MS) metabolomics data. Typically these values cover about 10%–20% of all data and can originate from various backgrounds, including analytical, co... Read More about Influence of missing values substitutes on multivariate analysis of metabolomics data.