All Outputs (2)

MafB restricts M-CSF-Dependent myeloid commitment divisions of hematopoietic stem cells (2009)
Journal Article
Sarrazin, S., Mossadegh-Keller, N., Fukao, T., Aziz, A., Mourcin, F., Vanhille, L., …Sieweke, M. (2009). MafB restricts M-CSF-Dependent myeloid commitment divisions of hematopoietic stem cells. Cell, 138(2), 300-313. https://doi.org/10.1016/j.cell.2009.04.057

While hematopoietic stem cell (HSC) self-renewal is well studied, it remains unknown whether distinct control mechanisms enable HSC divisions that generate progeny cells with specific lineage bias. Here, we report that the monocytic transcription fac... Read More about MafB restricts M-CSF-Dependent myeloid commitment divisions of hematopoietic stem cells.

MafB/c-Maf deficiency enables self-renewal of differentiated functional macrophages (2009)
Journal Article
Aziz, A., Soucie, E., Sarrazin, S., & Sieweke, M. (2009). MafB/c-Maf deficiency enables self-renewal of differentiated functional macrophages. Science, 326(5954), 867-871. https://doi.org/10.1126/science.1176056

In metazoan organisms, terminal differentiation is generally tightly linked to cell cycle exit, whereas the undifferentiated state of pluripotent stem cells is associated with unlimited self-renewal. Here, we report that combined deficiency for the t... Read More about MafB/c-Maf deficiency enables self-renewal of differentiated functional macrophages.