All Outputs (6)

Immune biomarkers predicting clinical outcomes for major trauma patients (2020)
Thesis
Saleem, A. Immune biomarkers predicting clinical outcomes for major trauma patients. (Dissertation). University of Salford

Major trauma continues to be the most common cause of death in the population under the age of 40 in England. Despite advances in trauma care in the UK, sepsis and multiple organ dysfunction syndrome (MODS) continue to be severe complications of trau... Read More about Immune biomarkers predicting clinical outcomes for major trauma patients.

Intranasal delivery of polymer-anchored lipid nanoconstructs of artemether-lumefantrine in plasmodium berghei ANKA murine model (2020)
Journal Article
Kaur, R., Gorki, V., Singh, G., Kaur, R., Katare, O., Nirmalan, N., & Singh, B. (2021). Intranasal delivery of polymer-anchored lipid nanoconstructs of artemether-lumefantrine in plasmodium berghei ANKA murine model. Journal of Drug Delivery Science and Technology, 61, 102114. https://doi.org/10.1016/j.jddst.2020.102114

Cerebral malaria is a serious plasmodial infection that calls for immediate treatment for parasitic clearance from brain. Oral regimen of cerebral malaria is an impracticable option, it being often associated with problems like impaired consciousness... Read More about Intranasal delivery of polymer-anchored lipid nanoconstructs of artemether-lumefantrine in plasmodium berghei ANKA murine model.

Homeostasis in dynamic self-regulatory physiological systems (2020)
Journal Article
Nirmalan, N., & Nirmalan, M. (2020). Homeostasis in dynamic self-regulatory physiological systems. Anaesthesia and Intensive Care Medicine, 21(11), 590-595. https://doi.org/10.1016/j.mpaic.2020.08.003

Understanding the general principles of homeostasis and its regulation in health and disease is key to managing patients in intensive care units and operating theatres. In these environments, it is crucial to realize that physiological control is a d... Read More about Homeostasis in dynamic self-regulatory physiological systems.

Hormonal control of metabolism : regulation of plasma glucose (2020)
Journal Article
Nirmalan, N., & Nirmalan, M. (2020). Hormonal control of metabolism : regulation of plasma glucose. Anaesthesia and Intensive Care Medicine, 21(11), 578-583. https://doi.org/10.1016/j.mpaic.2020.08.002

Blood glucose concentrations are required to be maintained within a narrow therapeutic range in order to ensure the normal functioning of the body. This is accomplished through a complex, interactive, finely coordinated neuro-endocrine regulatory pro... Read More about Hormonal control of metabolism : regulation of plasma glucose.

In vitro screening of Trametes versicolor and Acacia nilotica derivatives for antimalarial efficacy (2020)
Thesis
Dillon, M. In vitro screening of Trametes versicolor and Acacia nilotica derivatives for antimalarial efficacy. (Dissertation). University of Salford

Of the plethora of parasitic diseases that afflict mankind, malaria remains the most prevalent. The disease has caused severe global health problems, putting 3.2 billion people at risk of developing the Plasmodium infection. With current front-line t... Read More about In vitro screening of Trametes versicolor and Acacia nilotica derivatives for antimalarial efficacy.

Lead optimisation of dehydroemetine for repositioned use in malaria (2020)
Journal Article
Panwar, P., Burusco, K., Abubaker, M., Matthews, H., Gutnov, A., Fernández-Álvaro, E., …Nirmalan, N. (2020). Lead optimisation of dehydroemetine for repositioned use in malaria. Antimicrobial Agents and Chemotherapy, 64(4), 1-10. https://doi.org/10.1128/AAC.01444-19

Drug repositioning offers an effective alternative to de novo drug design to tackle the urgent need for novel anti-malarial treatments. The anti-amoebic compound, emetine dihydrochloride, has been identified as a potent in-vitro inhibitor of the mult... Read More about Lead optimisation of dehydroemetine for repositioned use in malaria.