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All Outputs (9)

Species identification and phylogenetic analysis of Leishmania isolated from patients, vectors and hares in the Xinjiang Autonomous Region, The People's Republic of China (2021)
Journal Article
Chen, Y., Liao, L., Wu, N., Gao, J., Zhang, P., Wen, Y., …Lun, Z. (2021). Species identification and phylogenetic analysis of Leishmania isolated from patients, vectors and hares in the Xinjiang Autonomous Region, The People's Republic of China. PLoS Neglected Tropical Diseases, 15(12), e0010055. https://doi.org/10.1371/journal.pntd.0010055

Visceral leishmaniasis (VL) has been declared as one of the six major tropical diseases by the World Health Organization. This disease has been successfully controlled in China, except for some areas in the western region, such as the Xinjiang Autono... Read More about Species identification and phylogenetic analysis of Leishmania isolated from patients, vectors and hares in the Xinjiang Autonomous Region, The People's Republic of China.

A new species of mammalian trypanosome, Trypanosoma (Megatrypanum) bubalisi sp. nov., found in the freshwater leech Hirudinaria manillensis (2021)
Journal Article
Su, B., Wang, J., Yang, T., Hide, G., Lai, D., & Lun, Z. (2021). A new species of mammalian trypanosome, Trypanosoma (Megatrypanum) bubalisi sp. nov., found in the freshwater leech Hirudinaria manillensis. International Journal for Parasitology, https://doi.org/10.1016/j.ijpara.2021.10.009

Leeches have long been considered potential vectors for the aquatic lineage of trypanosomes, while bloodsucking insects are generally considered as the vectors for the terrestrial lineage of trypanosomes. The freshwater leech, Hirudinaria manillensis... Read More about A new species of mammalian trypanosome, Trypanosoma (Megatrypanum) bubalisi sp. nov., found in the freshwater leech Hirudinaria manillensis.

Innate resistance to Leishmania amazonensis Infection in rat is dependent on NOS2 (2021)
Journal Article
Chen, Y., Yu, S., Wu, C., Wu, N., Shen, J., Shen, J., …Lun, Z. (2021). Innate resistance to Leishmania amazonensis Infection in rat is dependent on NOS2. Frontiers in Microbiology, 12, 733286. https://doi.org/10.3389/fmicb.2021.733286

Leishmania infection causes diverse clinical manifestations in humans. The disease outcome is complicated by the combination of many host and parasite factors. Inbred mouse strains vary in resistance to Leishmania major but are highly susceptible to... Read More about Innate resistance to Leishmania amazonensis Infection in rat is dependent on NOS2.

High resistance to Toxoplasma gondii infection in inducible nitric oxide synthase (iNOS) knockout rats (2021)
Journal Article
Wang, Z., Yu, S., Gao, J., Zhang, P., Hide, G., Yamamoto, M., …Lun, Z. (2021). High resistance to Toxoplasma gondii infection in inducible nitric oxide synthase (iNOS) knockout rats. iScience, 24(11), 103280. https://doi.org/10.1016/j.isci.2021.103280

Nitric oxide (NO) is an important immune molecule which acts against extra- and intracellular pathogens in most hosts. However, after knockout of inducible nitric oxide synthase (iNOS-/-) in Sprague Dawley (SD) rats, these iNOS-/- rats were found to... Read More about High resistance to Toxoplasma gondii infection in inducible nitric oxide synthase (iNOS) knockout rats.

The relationship between the infection of Toxoplasma gondii and Alzheimer’s disease (2021)
Thesis
Alawfi, B. (2021). The relationship between the infection of Toxoplasma gondii and Alzheimer’s disease. (Thesis). University of Salford

Toxoplasma gondii is a zoonotic parasite that commonly causes infections in a variety of warm-blooded animals including humans. This parasite causes a disease referred to as toxoplasmosis. T. gondii infections are known to have a significant impact o... Read More about The relationship between the infection of Toxoplasma gondii and Alzheimer’s disease.

Identification of an orally active carbazole aminoalcohol derivative with broad-spectrum anti-animal trypanosomiasis activity (2021)
Journal Article
Cai, X., Wang, W., Lai, D., Zhang, X., Yao, J., Yu, Y., …Lun, Z. (2021). Identification of an orally active carbazole aminoalcohol derivative with broad-spectrum anti-animal trypanosomiasis activity. Acta tropica, 219, 105919. https://doi.org/10.1016/j.actatropica.2021.105919

Animal trypanosomiasis, caused by the members of subgenus Trypanozoon (Trypanosoma brucei brucei, T. evansi and T. equiperdum), has reduced animal productivity leading to significant negative economic impacts in endemic regions. Due to limited drug d... Read More about Identification of an orally active carbazole aminoalcohol derivative with broad-spectrum anti-animal trypanosomiasis activity.

An investigation into Toxoplasma gondii infection and the expression of Arginase-1 and iNOS in human lung tissue (2021)
Thesis
Soothill, H. An investigation into Toxoplasma gondii infection and the expression of Arginase-1 and iNOS in human lung tissue. (Dissertation). University of Salford

This study aimed to investigate the relationship between Toxoplasma gondii infection and the expression of the immune modulating proteins Arginase-1 and iNOS in human lung biopsy samples. Previously, a 100% toxoplasmosis infection rate was found in 7... Read More about An investigation into Toxoplasma gondii infection and the expression of Arginase-1 and iNOS in human lung tissue.

Infection with Trypanosoma lewisi or Trypanosoma musculi may promote the spread of Toxoplasma gondii (2021)
Journal Article
Gao, J., Yi, S., Geng, G., Xu, Z., Hide, G., Lun, Z., & Lai, D. (2021). Infection with Trypanosoma lewisi or Trypanosoma musculi may promote the spread of Toxoplasma gondii. Parasitology, 148(6), 703-711. https://doi.org/10.1017/S0031182021000196

Toxoplasma gondii can infect almost all warm-blooded vertebrates with pathogensis being largely influenced by the host immune status. As important epidemiological hosts, rodents are globally distributed and are also commonly found infected with ha... Read More about Infection with Trypanosoma lewisi or Trypanosoma musculi may promote the spread of Toxoplasma gondii.