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All Outputs (5)

Defining the role of endonuclease VIII-like 1 and 3 in the repair of interstrand crosslinks in cancer cells (2022)
Thesis
Burberry, G. Defining the role of endonuclease VIII-like 1 and 3 in the repair of interstrand crosslinks in cancer cells. (Thesis). University of Salford

Fanconi Anaemia (FA) is an inherited autosomal-recessive disorder that can lead to abnormal development, bone-marrow failure, and an increased vulnerability to carcinogenesis. Cells derived from FA patients are unusually sensitive to DNA crosslinking... Read More about Defining the role of endonuclease VIII-like 1 and 3 in the repair of interstrand crosslinks in cancer cells.

Investigating the role of NEIL3 in colorectal cancer resistance to oxaliplatin
Thesis
Iwakun, O. Investigating the role of NEIL3 in colorectal cancer resistance to oxaliplatin. (Thesis). University of Salford

Colorectal cancer (CRC) is the third most common type of cancer and accounts for 8 % of cancer related deaths worldwide. While the likelihood of colorectal carcinogenesis increases with age, genetics and lifestyle are major predisposing factors. Trea... Read More about Investigating the role of NEIL3 in colorectal cancer resistance to oxaliplatin.

Expression and characterization of recombinant human NEIL3 from Escherichia coli
Thesis
Albelazi, M. (in press). Expression and characterization of recombinant human NEIL3 from Escherichia coli. (Thesis). University of Salford

The DNA glycosylase NEIL3 is one of a family of proteins that release oxidized bases from DNA, thereby initiating base excision repair. NEIL3 gene expression is normally tightly regulated and expressed only in certain rapidly dividing cells, however,... Read More about Expression and characterization of recombinant human NEIL3 from Escherichia coli.

The role of the human endonuclease VIII-like 1 and 3 in the repair of DNA replication blocking lesions
Thesis
Martin, P. (in press). The role of the human endonuclease VIII-like 1 and 3 in the repair of DNA replication blocking lesions. (Thesis). University of Salford

The endonuclease VIII family of DNA glycosylases initiate repair of oxidative DNA base damage through BER and have been shown to resolve DNA inter-strand crosslinks (ICLs), arising from exogenous agents. Human NEIL1 (hNEIL1) activity on psoralen gene... Read More about The role of the human endonuclease VIII-like 1 and 3 in the repair of DNA replication blocking lesions.