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Dr David Pye's Outputs (6)

Investigating the anti-proliferative properties and their mechanism(s) of action of marine derived glycosaminoglycans from two marine sources (2020)
Thesis
two marine sources. (Dissertation). University of Salford

The purpose of this study was to investigate the chemotherapeutic properties of marine derived glycosaminoglycans (GAGs) and investigate their mechanism(s) of action. The secondary purpose was to investigate differences between the already studied co... Read More about Investigating the anti-proliferative properties and their mechanism(s) of action of marine derived glycosaminoglycans from two marine sources.

Isolation and Composition Analysis of Bioactive Glycosaminoglycans from Whelk (2018)
Journal Article
Khurshid, C., & Pye, D. (2018). Isolation and Composition Analysis of Bioactive Glycosaminoglycans from Whelk. Marine Drugs, 16(5), 0171. https://doi.org/10.3390/md16050171

Glycosaminoglycans (GAGs) are found covalently attached to proteins, which create conjugates known as proteoglycans. GAGs have remarkable biological activity as co-receptors for a variety of growth factors, cytokines, and chemokines. The present stud... Read More about Isolation and Composition Analysis of Bioactive Glycosaminoglycans from Whelk.

Antiproliferative activity of glycosaminoglycan-like polysaccharides derived from marine molluscs (2018)
Journal Article
Aldairi, A., Ogundipe, O., & Pye, D. (2018). Antiproliferative activity of glycosaminoglycan-like polysaccharides derived from marine molluscs. Marine Drugs, 16(2), 63. https://doi.org/10.3390/md16020063

Despite the increasing availability of new classes of cancer treatment, such as immuneand
targeted therapies, there remains a need for the development of new antiproliferative/cytotoxic
drugs with improved pharmacological profiles that can also ove... Read More about Antiproliferative activity of glycosaminoglycan-like polysaccharides derived from marine molluscs.

Validation of shellfish isolates (glycosaminoglycans, GAGs) for development as a novel anti-tumour therapy for children : GAG action on lymphocytes/T-regulatory cells
Thesis
Jones, C. Validation of shellfish isolates (glycosaminoglycans, GAGs) for development as a novel anti-tumour therapy for children : GAG action on lymphocytes/T-regulatory cells. (Thesis). University of Salford

Introduction: Leukaemia is cancer of white blood cells (WBCs) mainly affecting children. Defective WBCs are prominent in blood and cannot provide immune protection. Although chemotherapy treatments are effective, they have many adverse effects which... Read More about Validation of shellfish isolates (glycosaminoglycans, GAGs) for development as a novel anti-tumour therapy for children : GAG action on lymphocytes/T-regulatory cells.