Dr Sarah Withers' Outputs (24)

Role of sympathetic nerves and adipocyte catecholamine uptake in the vasorelaxant function of perivascular adipose tissue. (2018)
Journal Article
Saxton, S., Ryding, K., Aldous, R., Withers, S., Ohanian, J., & Heagerty, A. (2018). Role of sympathetic nerves and adipocyte catecholamine uptake in the vasorelaxant function of perivascular adipose tissue. Arteriosclerosis, Thrombosis, and Vascular Biology, 38(4), 880-891. https://doi.org/10.1161/ATVBAHA.118.310777

Objective: Healthy perivascular adipose tissue (PVAT) exerts an anticontractile effect on resistance arteries which is vital in regulating arterial tone. Activation of β3 -adrenoceptors by sympathetic nerve-derived NA (noradrenaline) may be implicate... Read More about Role of sympathetic nerves and adipocyte catecholamine uptake in the vasorelaxant function of perivascular adipose tissue..

Eosinophils are key regulators of perivascular adipose tissue and vascular functionality (2017)
Journal Article
vascular functionality. Scientific reports, 7, 44571. https://doi.org/10.1038/srep44571

Obesity impairs the relaxant capacity of adipose tissue surrounding the vasculature (PVAT) and has
been implicated in resultant obesity-related hypertension and impaired glucose intolerance. Resident
immune cells are thought to regulate adipocyte a... Read More about Eosinophils are key regulators of perivascular adipose tissue and vascular functionality.

Obesity-related perivascular adipose tissue damage is reversed by sustained weight loss in the rat (2016)
Journal Article
Bussey, C., Withers, S., Aldous, R., Edwards, G., & Heagerty, A. (2016). Obesity-related perivascular adipose tissue damage is reversed by sustained weight loss in the rat. Arteriosclerosis, Thrombosis, and Vascular Biology, 36(7), 1377-1385. https://doi.org/10.1161/ATVBAHA.116.307210

Objective – Perivascular adipose tissue (PVAT) exerts an anticontractile effect in response to various vasoconstrictor agonists and this is lost in obesity. A recent study reported that bariatric surgery reverses the damaging effects of obesity on PV... Read More about Obesity-related perivascular adipose tissue damage is reversed by sustained weight loss in the rat.

Mechanisms of adiponectin-associated perivascular function in vascular disease (2014)
Journal Article
Withers, S., Bussey, C., Saxton, S., Melrose, H., Watkins, A., & Heagerty, A. (2014). Mechanisms of adiponectin-associated perivascular function in vascular disease. Arteriosclerosis, Thrombosis, and Vascular Biology, 34(8), 1637-42. https://doi.org/10.1161/ATVBAHA.114.303031

The concept that fat cells could influence the circulation and indeed cardiac function has been in existence for ≥20 years and has gained a wide interest and no less excitement as evidence has accrued to suggest that such effects may be profound enou... Read More about Mechanisms of adiponectin-associated perivascular function in vascular disease.