Dr Berna Sayan's Outputs (3)

p63 is upstream of IKKα in epidermal development (2006)
Journal Article

The epidermis, the outer layer of the skin composed of keratinocytes, develops following the action of the transcription factor p63. The mouse Trp63 gene contains two promoters, driving the production of distinct proteins, one with an N-terminal tran... Read More about p63 is upstream of IKKα in epidermal development.

p63 and p73, members of the p53 gene family, transactivate PKCδ (2006)
Journal Article

The p53 family comprises three genes that encode for p53, p63 and p73. These genes have a significant degree of sequence homology, especially in the central sequence-specific DNA-binding domain. The high homology among the three DNA-binding domains i... Read More about p63 and p73, members of the p53 gene family, transactivate PKCδ.

p53 is cleaved by caspases generating fragments localizing to mitochondria (2006)
Journal Article
Sayan, B., Sayan, A., Knight, R., Melino, G., & Cohen, G. (2006). p53 is cleaved by caspases generating fragments localizing to mitochondria. Journal of Biological Chemistry, 281(19), 13566-13573. https://doi.org/10.1074/jbc.M512467200

The p53 tumor suppressor protein exerts most of its anti-tumorigenic activity by transcriptionally activating several pro-apoptotic genes. Accumulating evidence also suggests a transcription-independent function of p53 during apoptosis. It has recent... Read More about p53 is cleaved by caspases generating fragments localizing to mitochondria.