Dr Ilan Ruhr's Outputs (23)

Developmental programming of DNA methylation and gene expression patterns is associated with extreme cardiovascular tolerance to anoxia in the common snapping turtle (2021)
Journal Article

Background
Environmental fluctuation during embryonic and fetal development can permanently alter an organism’s morphology, physiology, and behaviour. This phenomenon, known as developmental plasticity, is particularly relevant to reptiles that deve... Read More about Developmental programming of DNA methylation and gene expression patterns is associated with extreme cardiovascular tolerance to anoxia in the common snapping turtle.

Developmental programming of sarcoplasmic reticulum function improves cardiac anoxia tolerance in turtles (2024)
Journal Article
Ruhr, I. M., Shiels, H. A., Crossley, D. A., & Galli, G. L. J. (2024). Developmental programming of sarcoplasmic reticulum function improves cardiac anoxia tolerance in turtles. Journal of Experimental Biology, 227(20), Article jeb247434. https://doi.org/10.1242/jeb.247434

Oxygen deprivation during embryonic development can permanently remodel the vertebrate heart, often causing cardiovascular abnormalities in adulthood. While this phenomenon is mostly damaging, recent evidence suggests developmental hypoxia produces s... Read More about Developmental programming of sarcoplasmic reticulum function improves cardiac anoxia tolerance in turtles.

Low production of mitochondrial reactive oxygen species after anoxia and reoxygenation in turtle hearts (2023)
Journal Article

Extremely anoxia-tolerant animals, such as freshwater turtles, survive anoxia and reoxygenation without sustaining tissue damage to their hearts. In contrast, for mammals, the ischemia–reperfusion (IR) injury that leads to tissue damage during a hear... Read More about Low production of mitochondrial reactive oxygen species after anoxia and reoxygenation in turtle hearts.

Developmental plasticity of cardiac anoxia-tolerance in juvenile common snapping turtles (Chelydra serpentina) (2019)
Journal Article

For some species of ectothermic vertebrates, early exposure to hypoxia during embryonic development improves hypoxia-tolerance later in life. However, the cellular mechanisms underlying this phenomenon are largely unknown. Given that hypoxic survival... Read More about Developmental plasticity of cardiac anoxia-tolerance in juvenile common snapping turtles (Chelydra serpentina).

Metabolic adaptations to anoxia and reoxygenation: New lessons from freshwater turtles and crucian carp (2020)
Journal Article

As the final electron acceptor in the electron transport chain, oxygen is vital to produce ATP in the process of oxidative phosphorylation. In most vertebrates, the absence of oxygen (anoxia) quickly leads to an imbalance of ATP supply and demand and... Read More about Metabolic adaptations to anoxia and reoxygenation: New lessons from freshwater turtles and crucian carp.

The Long-Term Effects of Developmental Hypoxia on Cardiac Mitochondrial Function in Snapping Turtles (2021)
Journal Article

It is well established that adult vertebrates acclimatizing to hypoxic environments undergo mitochondrial remodeling to enhance oxygen delivery, maintain ATP, and limit oxidative stress. However, many vertebrates also encounter oxygen deprivation dur... Read More about The Long-Term Effects of Developmental Hypoxia on Cardiac Mitochondrial Function in Snapping Turtles.

Turning turtle: scaling relationships and self-righting ability in Chelydra serpentina (2021)
Journal Article

Testudines are susceptible to inversion and self-righting using their necks, limbs or both, to generate enough mechanical force to flip over. We investigated how shell morphology, neck length and self-righting biomechanics scale with body mass during... Read More about Turning turtle: scaling relationships and self-righting ability in Chelydra serpentina.

Too hot or just right during embryonic development in lizards? (2020)
Journal Article

The big problem with microplastic pollution (2020)
Journal Article

A beach festival isn't a sound idea to fish (2020)
Journal Article

A marine teleost, Opsanus beta, compensates acidosis in hypersaline water by H+ excretion or reduced HCO3− excretion rather than HCO3− uptake (2020)
Journal Article

Increases in ambient salinity demand parallel increases in intestinal base secretion for maintenance of osmoregulatory status, which is likely the cause of a transient acidosis following transfer of euryhaline fish from freshwater to seawater. It was... Read More about A marine teleost, Opsanus beta, compensates acidosis in hypersaline water by H+ excretion or reduced HCO3− excretion rather than HCO3− uptake.

Is aquaporin‐3 involved in water‐permeability changes in the killifish during hypoxia and normoxic recovery, in freshwater or seawater? (2020)
Journal Article

Aquaporins are the predominant water-transporting proteins in vertebrates, but only a handful of studies have investigated aquaporin function in fish, particularly in mediating water permeability during salinity challenges. Even less is known about a... Read More about Is aquaporin‐3 involved in water‐permeability changes in the killifish during hypoxia and normoxic recovery, in freshwater or seawater?.

Arctic fish aren’t cool about hotter water (2020)
Journal Article

Pain insensitivity: Subtle changes make a huge difference (2019)
Journal Article

Insects that stink and hatch in sync (2019)
Journal Article

A soaring success: Repeated evolution of island flightlessness (2019)
Journal Article

The osmorespiratory compromise in the euryhaline killifish: water regulation during hypoxia (2019)
Journal Article

Freshwater- and seawater-acclimated Fundulus heteroclitus were exposed to acute hypoxia (10% air saturation, 3 h), followed by normoxic recovery (3 h). In both salinities, ventilation increased and heart rate fell in the classic manner, while ṀO2 in... Read More about The osmorespiratory compromise in the euryhaline killifish: water regulation during hypoxia.

Crude awakening: larval mahi-mahi can't handle the heat (2019)
Journal Article

Renoguanylin stimulates apical CFTR translocation and decreases HCO3− secretion through PKA activity in the Gulf toadfish (Opsanus beta) (2018)
Journal Article

The guanylin peptides – guanylin, uroguanylin and renoguanylin (RGN) – are endogenously produced hormones in teleost fish enterocytes that are activators of guanylyl cyclase-C (GC-C) and are potent modulators of intestinal physiology, particularly in... Read More about Renoguanylin stimulates apical CFTR translocation and decreases HCO3− secretion through PKA activity in the Gulf toadfish (Opsanus beta).

The role of the rectum in osmoregulation and the potential effect of renoguanylin on SLC26a6 transport activity in the Gulf toadfish (Opsanus beta) (2016)
Journal Article

The role of the rectum in osmo- regulation and the potential effect of renoguanylin on SLC26a6 transport activity in the Gulf toadfish (Opsanus beta). Am J Physiol Regul Integr Comp Physiol 311: R179 –R191, 2016. First published March 30, 2016; doi:10... Read More about The role of the rectum in osmoregulation and the potential effect of renoguanylin on SLC26a6 transport activity in the Gulf toadfish (Opsanus beta).