Dr Mark McAuley's Outputs (5)

The Interplay Between Cholesterol Metabolism and Intrinsic Ageing (2018)
Book Chapter

The last few decades have witnessed remarkable progress in our understanding of ageing. From an evolutionary standpoint it is generally accepted that ageing is a non-adaptive process which is underscored by a decrease in the force of natural selectio... Read More about The Interplay Between Cholesterol Metabolism and Intrinsic Ageing.

Mathematical models of DNA methylation dynamics: Implications for health and ageing (2018)
Journal Article

DNA methylation is a key epigenetic process which has been intimately associated with gene regulation. In recent years growing evidence has associated DNA methylation status with a variety of diseases including cancer, Alzheimer’s disease and cardiov... Read More about Mathematical models of DNA methylation dynamics: Implications for health and ageing.

Disrupting folate metabolism reduces the capacity of bacteria in exponential growth to develop persisters to antibiotics (2018)
Journal Article

Bacteria can survive high doses of antibiotics through stochastic phenotypic diversification. We present initial evidence that folate metabolism could be involved with the formation of persisters. The aberrant expression of the folate enzyme gene fau... Read More about Disrupting folate metabolism reduces the capacity of bacteria in exponential growth to develop persisters to antibiotics.

The role of DNA methylation in ageing and cancer (2018)
Journal Article
Morgan, A. E., Davies, T. J., & Mc Auley, M. T. (2018). The role of DNA methylation in ageing and cancer. Proceedings of the Nutrition Society, 77(4), 412-422. https://doi.org/10.1017/S0029665118000150

The aim of the present review paper is to survey the literature related to DNA methylation, and its association with cancer and ageing. The review will outline the key factors, including diet, which modulate DNA methylation. Our rationale for conduct... Read More about The role of DNA methylation in ageing and cancer.

Using Computational Models to Study Aging (2018)
Book Chapter

Population aging has resulted in remarkable demographic changes. The global population will soon have more older people than children and more people at extreme old age than ever before. Despite this increased longevity, many older people do not age... Read More about Using Computational Models to Study Aging.