Dr Mark McAuley's Outputs (45)

The evolution of ageing: classic theories and emerging ideas (2024)
Journal Article
Mc Auley, M. T. (2025). The evolution of ageing: classic theories and emerging ideas. Biogerontology, 26(1), 6. https://doi.org/10.1007/s10522-024-10143-5

Ageing is generally regarded as a non-adaptive by-product of evolution. Based on this premise three classic evolutionary theories of ageing have been proposed. These theories have dominated the literature for several decades. Despite their individual... Read More about The evolution of ageing: classic theories and emerging ideas.

Vascular dementia: From pathobiology to emerging perspectives (2024)
Journal Article
Elizabeth Morgan, A., McAuley, M. T., & Tomás Mc Auley, M. (2024). Vascular dementia: From pathobiology to emerging perspectives. Ageing research reviews, 96, 102278. https://doi.org/10.1016/j.arr.2024.102278

Vascular dementia (VaD) is the second most common type of dementia. VaD is synonymous with ageing, and its symptoms place a significant burden on the health and wellbeing of older people. Despite the identification of a substantial... Read More about Vascular dementia: From pathobiology to emerging perspectives.

A new mathematical model of folate homeostasis in E. coli highlights the potential importance of the folinic acid futile cycle in cell growth. (2023)
Journal Article
Morgan, A., Salcedo-Sora, J. E., & Mc Auley, M. T. (2024). A new mathematical model of folate homeostasis in E. coli highlights the potential importance of the folinic acid futile cycle in cell growth. BioSystems, 235, 105088. https://doi.org/10.1016/j.biosystems.2023.105088

Folate (vitamin B9) plays a central role in one-carbon metabolism in prokaryotes and eukaryotes. This pathway mediates the transfer of one-carbon units, playing a crucial role in nucleotide synthesis, methylation, and amino acid homeostasis. The foli... Read More about A new mathematical model of folate homeostasis in E. coli highlights the potential importance of the folinic acid futile cycle in cell growth..

An evolutionary perspective of lifespan and epigenetic inheritance (2023)
Journal Article

In the last decade epigenetics has come to the fore as a discipline which is central to biogerontology. Age associated epigenetic changes are routinely linked with pathologies, including cardiovascular disease, cancer, and Alzheimer's disease; moreov... Read More about An evolutionary perspective of lifespan and epigenetic inheritance.

Computationally Modelling Cholesterol Metabolism and Atherosclerosis (2023)
Journal Article
Davies, C., Morgan, A. E., & Mc Auley, M. T. (2023). Computationally Modelling Cholesterol Metabolism and Atherosclerosis. Biology, 12(8), 1133. https://doi.org/10.3390/biology12081133

Cardiovascular disease (CVD) is the leading cause of death globally. The underlying pathological driver of CVD is atherosclerosis. The primary risk factor for atherosclerosis is elevated low-density lipoprotein cholesterol (LDL-C). Dysregulation of c... Read More about Computationally Modelling Cholesterol Metabolism and Atherosclerosis.

Dietary restriction and ageing: Recent evolutionary perspectives (2022)
Journal Article

Dietary restriction (DR) represents one of the most robust interventions for extending lifespan. It is not known how DR increases lifespan. The prevailing evolutionary hypothesis suggests the DR response redirects metabolic resources towards somatic... Read More about Dietary restriction and ageing: Recent evolutionary perspectives.

Cholesterol transport in blood, lipoproteins, and cholesterol metabolism (2022)
Book Chapter
Mc Auley, M. T., & Morgan, A. E. (2022). Cholesterol transport in blood, lipoproteins, and cholesterol metabolism. . Elsevier. https://doi.org/10.1016/B978-0-323-85857-1.00025-0

The aim of this chapter is to critically discuss recent work which has focused on the dynamics of cholesterol transport and its intersection with health. Firstly, we provide an overview of the main lipoproteins, and their role in whole-body cholester... Read More about Cholesterol transport in blood, lipoproteins, and cholesterol metabolism.

Aging and Cholesterol Metabolism (2021)
Book Chapter

Diet is the only known intervention which has been conclusively shown to extend life span. It can be argued the key role diet has to play in the aging process came to prominence as a result of the seminal studies of Mc Cay and colleagues in the 1930s... Read More about Aging and Cholesterol Metabolism.

Modeling cholesterol metabolism and atherosclerosis (2021)
Journal Article

Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of morbidity and mortality among Western populations. Many risk factors have been identified for ASCVD; however, elevated low-density lipoprotein cholesterol (LDL-C) remains the gold... Read More about Modeling cholesterol metabolism and atherosclerosis.

DNA methylation in genes associated with the evolution of ageing and disease: A critical review (2021)
Journal Article

Ageing is characterised by a physical decline in biological functioning which results in a progressive risk of mortality with time. As a biological phenomenon, it is underpinned by the dysregulation of a myriad of complex processes. Recently, however... Read More about DNA methylation in genes associated with the evolution of ageing and disease: A critical review.

The interdependency and co-regulation of the vitamin D and cholesterol metabolism (2021)
Journal Article

Vitamin D and cholesterol metabolism overlap significantly in the pathways that contribute to their biosynthesis. However, our understanding of their independent and co-regulation is limited. Cardiovascular disease is the leading cause of death globa... Read More about The interdependency and co-regulation of the vitamin D and cholesterol metabolism.

Electrochemically detecting DNA methylation in the EN1 gene promoter: Implications for understanding ageing and disease (2020)
Journal Article
Morgan, A. E., Acutt, K. D., & Mc Auley, M. (2020). Electrochemically detecting DNA methylation in the EN1 gene promoter: Implications for understanding ageing and disease. Bioscience Reports, 40(11), https://doi.org/10.1042/BSR20202571

There is a growing need for biomarkers which predict age-onset pathology. Although this is challenging, the methylome offers significant potential. Cancer is associated with the hypermethylation of many gene promoters, among which are developmental g... Read More about Electrochemically detecting DNA methylation in the EN1 gene promoter: Implications for understanding ageing and disease.

Cholesterol Homeostasis: An In Silico Investigation into How Aging Disrupts Its Key Hepatic Regulatory Mechanisms (2020)
Journal Article
Morgan, A. E., & Mc Auley, M. T. (2020). Cholesterol Homeostasis: An In Silico Investigation into How Aging Disrupts Its Key Hepatic Regulatory Mechanisms. Biology, 9(10), Article 314. https://doi.org/10.3390/biology9100314

The dysregulation of intracellular cholesterol homeostasis is associated with several age-related diseases, most notably cardiovascular disease (CVD). Research in this area has benefitted from using computational modelling to study the inherent compl... Read More about Cholesterol Homeostasis: An In Silico Investigation into How Aging Disrupts Its Key Hepatic Regulatory Mechanisms.

Effects of obesity on cholesterol metabolism and its implications for healthy ageing (2020)
Journal Article

The last few decades have witnessed a global rise in the number of older individuals. Despite this demographic shift, morbidity within this population group is high. Many factors influence healthspan; however, an obesity pandemic is emerging as a sig... Read More about Effects of obesity on cholesterol metabolism and its implications for healthy ageing.

Computer Modelling for Nutritionists (2019)
Book

This book draws on Mark Mc Auley’s wealth of experience to provide an intuitive step-by-step guide to the modelling process. It also provides case studies detailing the creation of biological process models. Mark Mc Auley has over 15 years’ experienc... Read More about Computer Modelling for Nutritionists.

Systems-Based Mechanisms of Aging (2019)
Book Chapter
Proctor, C. J., Morgan, A. E., & Mc Auley, M. T. (2019). Systems-Based Mechanisms of Aging. In Encyclopedia of Biomedical Gerontology (332-345). Elsevier. https://doi.org/10.1016/B978-0-12-801238-3.11424-2

The last number of decades have witnessed an unrelenting global rise in the number of older people. This demographic shift is laudable; however, many older people are burdened by poor health. The main reason so many older people have their healthspan... Read More about Systems-Based Mechanisms of Aging.

Data-driven selection and parameter estimation for DNA methylation mathematical models (2019)
Journal Article

Epigenetics is coming to the fore as a key process which underpins health. In particular emerging experimental evidence has associated alterations to DNA methylation status with healthspan and aging. Mammalian DNA methylation status is maintained by... Read More about Data-driven selection and parameter estimation for DNA methylation mathematical models.

The Interplay Between Cholesterol Metabolism and Intrinsic Ageing (2018)
Book Chapter

The last few decades have witnessed remarkable progress in our understanding of ageing. From an evolutionary standpoint it is generally accepted that ageing is a non-adaptive process which is underscored by a decrease in the force of natural selectio... Read More about The Interplay Between Cholesterol Metabolism and Intrinsic Ageing.

Mathematical models of DNA methylation dynamics: Implications for health and ageing (2018)
Journal Article

DNA methylation is a key epigenetic process which has been intimately associated with gene regulation. In recent years growing evidence has associated DNA methylation status with a variety of diseases including cancer, Alzheimer’s disease and cardiov... Read More about Mathematical models of DNA methylation dynamics: Implications for health and ageing.

Disrupting folate metabolism reduces the capacity of bacteria in exponential growth to develop persisters to antibiotics (2018)
Journal Article

Bacteria can survive high doses of antibiotics through stochastic phenotypic diversification. We present initial evidence that folate metabolism could be involved with the formation of persisters. The aberrant expression of the folate enzyme gene fau... Read More about Disrupting folate metabolism reduces the capacity of bacteria in exponential growth to develop persisters to antibiotics.