Caveolae and signalling in cancer (2015)
Journal Article
Martinez-Outschoorn, U., Sotgia, F., & Lisanti, M. (2015). Caveolae and signalling in cancer. Nature Reviews Cancer, 15(4), 225-37. https://doi.org/10.1038/nrc3915

It has been over 20 years since the discovery that caveolar lipid rafts function as signalling organelles. Lipid rafts create plasma membrane heterogeneity, and caveolae are the most extensively studied subset of lipid rafts. A newly emerging paradig... Read More about Caveolae and signalling in cancer.

Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types : treating cancer like an infectious disease (2015)
Journal Article
Lamb, R., Ozsvari, B., Lisanti, C., Tanowitz, H., Howell, A., Martinez-Outschoorn, U., …Lisanti, M. (2015). Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types : treating cancer like an infectious disease. Oncotarget, 6(7), 4569-84. https://doi.org/10.18632/oncotarget.3174

Here, we propose a new strategy for the treatment of early cancerous lesions and advanced metastatic disease, via the selective targeting of cancer stem cells (CSCs), a.k.a., tumor-initiating cells (TICs). We searched for a global phenotypic characte... Read More about Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types : treating cancer like an infectious disease.

Metabolic asymmetry in cancer : a “balancing act” that promotes tumor growth (2014)
Journal Article
Martinez-Outschoorn, U., Sotgia, F., & Lisanti, M. (2014). Metabolic asymmetry in cancer : a “balancing act” that promotes tumor growth. Cancer Cell, 26(1), 5-7. https://doi.org/10.1016/j.ccr.2014.06.021

Profound metabolic differences between cancer cells and fibroblasts promote tumorigenesis. A study by Valencia and colleagues in this issue of Cancer Cell supports this assertion. They observed that metabolic asymmetry in prostate tumors drives aggre... Read More about Metabolic asymmetry in cancer : a “balancing act” that promotes tumor growth.

CAPER, a novel regulator of human breast cancer progression (2014)
Journal Article
Mercier, I., Gonzales, D., Quann, K., Pestell, T., Molchansky, A., Sotgia, F., …Jasmin, J. (2014). CAPER, a novel regulator of human breast cancer progression. Cell Cycle, 13(8), 1256-1264. https://doi.org/10.4161/cc.28156

CAPE R is an estrogen receptor (ER) co-activator that was recently shown to be involved in human breast cancer pathogenesis. Indeed, we reported increased expression of CAPE R in human breast cancer specimens. We demonstrated that CAPE R was undete... Read More about CAPER, a novel regulator of human breast cancer progression.

Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth (2014)
Journal Article
Martinez-Outschoorn, U., Lisanti, M., & Sotgia, F. (2014). Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth. Seminars in Cancer Biology, 25, 47-60. https://doi.org/10.1016/j.semcancer.2014.01.005

Fibroblasts are the most abundant “non-cancerous” cells in tumors. However, it remains largely unknown how these cancer-associated fibroblasts (CAFs) promote tumor growth and metastasis, driving chemotherapy resistance and poor clinical outcome. Th... Read More about Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth.

JNK1 stress signaling is hyper-activated in high breast density and the tumor stroma: Connecting fibrosis, inflammation, and stemness for cancer prevention (2013)
Journal Article
Lisanti, M., Reeves, K., Peiris-Pagès, M., Chadwick, A., Sanchez-Alvarez, R., Howell, A., …Sotgia, F. (2014). JNK1 stress signaling is hyper-activated in high breast density and the tumor stroma: Connecting fibrosis, inflammation, and stemness for cancer prevention. Cell Cycle, 13(4), 580-599. https://doi.org/10.4161/cc.27379

Mammography is an important screening modality for the early detection of DCIS and breast cancer lesions. More specifically, high mammographic density is associated with an increased risk of breast cancer. However, the biological processes underlying... Read More about JNK1 stress signaling is hyper-activated in high breast density and the tumor stroma: Connecting fibrosis, inflammation, and stemness for cancer prevention.