Targeting c-met in sonic hedgehog medulloblastomas (2022)
Thesis
Morlando, S. Targeting c-met in sonic hedgehog medulloblastomas. (Thesis). University of Salford

Medulloblastoma (MB), a cerebellar tumour primarily diagnosed in children, is the most common malignant brain tumour consisting of four molecular subgroups: Wingless (WNT), Sonic Hedgehog (SHH), Group 3 and Group 4. Although the 70-75% of MB patients... Read More about Targeting c-met in sonic hedgehog medulloblastomas.

Expanding the scope of the Babler-Daubin oxidation : 1,3-oxidative transposition of secondary allylic alcohols (2016)
Journal Article
Killoran, P., Rossington, S., Wilkinson, J., & Hadfield, J. (2016). Expanding the scope of the Babler-Daubin oxidation : 1,3-oxidative transposition of secondary allylic alcohols. Tetrahedron Letters, 57(35), 3954-3957. https://doi.org/10.1016/j.tetlet.2016.07.076

We report the catalytic chromium-mediated oxidation of secondary allylic alcohols to give α,β-unsaturated aldehydes with exclusive (E)-stereoselectivity. This facile procedure employs catalytic PCC (5 mol%) and periodic acid (H5IO6) as a co-oxidant.... Read More about Expanding the scope of the Babler-Daubin oxidation : 1,3-oxidative transposition of secondary allylic alcohols.

Asymmetric synthesis of diarylmethane derivatives by dynamic kinetic resolution (2015)
Journal Article
kinetic resolution. Tetrahedron Letters, 56(26), 4025-4027. https://doi.org/10.1016/j.tetlet.2015.05.006

Asymmetric allylation of ortho-methoxydiphenylmethane has been carried out with high yields and ee of up to 94% using the chiral ligand (−)-sparteine as an additive. Results of reactions performed under various conditions suggest that a dynamic kinet... Read More about Asymmetric synthesis of diarylmethane derivatives by dynamic kinetic resolution.

Asymmetric alkylation of diarylmethane derivatives (2006)
Journal Article
Wilkinson, J., Rossington, S., Ducki, S., Leonard, J., & Hussain, N. (2006). Asymmetric alkylation of diarylmethane derivatives. Tetrahedron, 62(8), 1833-1844. https://doi.org/10.1016/j.tet.2005.11.044

Deprotonation–alkylation of prochiral diarylmethane substrates using sec-BuLi and (−)-sparteine has been carried out in excellent yields and up to 94% ee. A variety of enantioselective alkylations, silylations and stannylations have been performed on... Read More about Asymmetric alkylation of diarylmethane derivatives.

Towards the total synthesis of tangutorine by intramolecular Diels–Alder reaction (2005)
Journal Article
Wilkinson, J., Ardes-Guisot, N., Ducki, S., & Leonard, J. (2005). Towards the total synthesis of tangutorine by intramolecular Diels–Alder reaction. Tetrahedron Letters, 46(46), 8053-8056. https://doi.org/10.1016/j.tetlet.2005.09.058

The syntheses of 3,5-disubstituted-2-sulfolenes, and their participation in Pictet-Spengler reactions to give precursors of tangutorine, are described.

Asymmetric alkylation of diarylmethane derivatives. Improved results using methoxyethoxy substituent (2004)
Journal Article
Wilkinson, J., Rossington, S., Leonard, J., & Hussain, N. (2004). Asymmetric alkylation of diarylmethane derivatives. Improved results using methoxyethoxy substituent. Tetrahedron Letters, 45(28), 5481-5483. https://doi.org/10.1016/j.tetlet.2004.05.058

Alkylation of 2-methoxyethoxyphenyl phenyl methane using sec-BuLi and (−)-sparteine has been carried out in excellent yields and up to 94% ee. The best results were obtained in allylation reactions but methylation, ethylation, benzylation and trimeth... Read More about Asymmetric alkylation of diarylmethane derivatives. Improved results using methoxyethoxy substituent.

Asymmetric alkylation of diphenylmethane derivatives using (-)-sparteine (2004)
Journal Article
Wilkinson, J., Rossington, S., Leonard, J., & Hussain, N. (2004). Asymmetric alkylation of diphenylmethane derivatives using (-)-sparteine. Tetrahedron Letters, 45(6), 1191-1193. https://doi.org/10.1016/j.tetlet.2003.11.138

Alkylation of 2-oxygenated diphenylmethane derivatives using sec-butyllithium and (−)-sparteine gave enantiomeric excesses of up to 60% with allyl bromide but alkylations with methyl electrophiles were poorly selective. When compounds with a free hyd... Read More about Asymmetric alkylation of diphenylmethane derivatives using (-)-sparteine.