Investigating calcium channel blockers as antimalarials
Thesis
Rajab, M. (in press). Investigating calcium channel blockers as antimalarials. (Thesis). University of Salford

The rise in resistance to current antimalarial drugs has led researchers to consider drug repositioning as a quicker alternative for drug development and discovery. Preliminary drug repositioning screens carried out at the University of Salford ident... Read More about Investigating calcium channel blockers as antimalarials.

Use of an 18s rRNA metagenomics approach as a method of detection of multiple infections in field blood samples collected on FTA cards from cattle
Thesis
West, D. (in press). Use of an 18s rRNA metagenomics approach as a method of detection of multiple infections in field blood samples collected on FTA cards from cattle. (Dissertation). University of Salford

Parasitic disease causes major health problems in humans and animals globally. Diseases in tropical and remote areas, sometimes known as neglected tropical diseases, pose some of the greater problems due to the difficulty in collecting and analysing... Read More about Use of an 18s rRNA metagenomics approach as a method of detection of multiple infections in field blood samples collected on FTA cards from cattle.

New molecular and cellular aspects of mutant calreticulin in Myeloproliferative Neoplasms
Thesis
Morlan-mairal, M. (in press). New molecular and cellular aspects of mutant calreticulin in Myeloproliferative Neoplasms. (Thesis). University of Salford

Calreticulin (CALR) is an endoplasmic reticulum (ER) protein that plays an important role as a calcium (Ca2+) buffering chaperone. Mutations in CALR exon 9 have been identified in essential thrombocythemia and primary myelofibrosis, two myeloprolifer... Read More about New molecular and cellular aspects of mutant calreticulin in Myeloproliferative Neoplasms.

Novel markers for human T regulatory cells in healthy donors and cancer patients
Thesis
Abd Al Samid, M. (in press). Novel markers for human T regulatory cells in healthy donors and cancer patients. (Thesis). University of Salford

CD4+CD25+FoxP3+ T regulatory cells (Tregs) are essential for maintaining self-tolerance and preventing autoimmune diseases. However, FoxP3+ Tregs contribute to the progression of cancer and their levels expand in cancer patients compared to healthy d... Read More about Novel markers for human T regulatory cells in healthy donors and cancer patients.

Arthropod-borne infections in the United Kingdom and Saudi Arabia
Thesis
Alharbi, B. (in press). Arthropod-borne infections in the United Kingdom and Saudi Arabia. (Thesis). University of Salford

Arthropod vectors can transmit different diseases that are both a significant and widespread cause of mortality and morbidity in both human and wildlife species. However, further studies are required to identify the role of wildlife species as reserv... Read More about Arthropod-borne infections in the United Kingdom and Saudi Arabia.

Characterising human lung tissue for biomarkers of EMT-fibrosis and functional steroid receptor components in chronic obstructive pulmonary disease (COPD) patients and control subjects
Thesis
Patel, H. (in press). Characterising human lung tissue for biomarkers of EMT-fibrosis and functional steroid receptor components in chronic obstructive pulmonary disease (COPD) patients and control subjects. (Dissertation). University of Salford

COPD is a poorly reversible airflow obstruction commonly induced by cigarette smoke. Pathology is linked to a series of inflammatory and fibrotic events in the small airways and lung parenchyma; including fibrosis, emphysema and mucus plugging. Thi... Read More about Characterising human lung tissue for biomarkers of EMT-fibrosis and functional steroid receptor components in chronic obstructive pulmonary disease (COPD) patients and control subjects.

Investigation of DNA variation in genes of the immune system in wild populations of Apodemus sylvaticus in relation to infection by Toxoplasma gondii and helminth parasites
Thesis
Shater, A. (in press). Investigation of DNA variation in genes of the immune system in wild populations of Apodemus sylvaticus in relation to infection by Toxoplasma gondii and helminth parasites. (Thesis). University of Salford

The aims of this study are to investigate DNA sequence variation in immune genes from Apodemus sylvaticus in relation to parasite infection. The purpose is to investigate the hypothesis that immune gene variation can influence parasite infection. Evi... Read More about Investigation of DNA variation in genes of the immune system in wild populations of Apodemus sylvaticus in relation to infection by Toxoplasma gondii and helminth parasites.

Exploring the ecologies of campylobacter and eimeria infections in UK sheep
Thesis
Al-neama, R. (in press). Exploring the ecologies of campylobacter and eimeria infections in UK sheep. (Thesis). University of Salford

Several gastrointestinal parasites of sheep have veterinary and zoonotic importance, including coccidia belonging to the genus Eimeria and proteobacteria belonging to the genus Campylobacter. In the UK, both Eimeria and Campylobacter are both frequ... Read More about Exploring the ecologies of campylobacter and eimeria infections in UK sheep.

Analysis of drug resistance and the role of the stem cell niche in leukaemia
Thesis
Bakker, E. (in press). Analysis of drug resistance and the role of the stem cell niche in leukaemia. (Thesis). University of Salford

Glucocorticoids and etoposide are used to treat acute lymphoblastic leukaemia (ALL) as they induce death in lymphoblasts through the glucocorticoid receptor (GR) and p53. However, glucocorticoid resistance, cell death mechanisms and the contribution... Read More about Analysis of drug resistance and the role of the stem cell niche in leukaemia.

Bats and their endoparasites : characterising pipistrelle infections and toll-like receptor (TLR2 and TLR4) gene variations
Thesis
Gattan, H. (in press). Bats and their endoparasites : characterising pipistrelle infections and toll-like receptor (TLR2 and TLR4) gene variations. (Thesis). University of Salford

Bats are unique mammals since they are able to fly and due to their crucial ecosystem roles, they are designated as keystone species. However, in many parts of the world, it is difficult to study bats due to the existence of protective legislation ca... Read More about Bats and their endoparasites : characterising pipistrelle infections and toll-like receptor (TLR2 and TLR4) gene variations.

Characterising the microbial communities associated with the water distribution system of a broiler farm and their role in Campylobacter infection
Thesis
Aranega Bou, P. Characterising the microbial communities associated with the water distribution system of a broiler farm and their role in Campylobacter infection. (Thesis). University of Salford

Campylobacters are zoonotic pathogens with extensive animal and environmental reservoirs in spite of their fastidious nature. Campylobacter jejuni is the main bacterial cause of human gastroenteritis worldwide. Epidemiological studies have identified... Read More about Characterising the microbial communities associated with the water distribution system of a broiler farm and their role in Campylobacter infection.

Dental biofilm formation in young children and the long term effects of fluoride varnish
Thesis
Greenwood, D. Dental biofilm formation in young children and the long term effects of fluoride varnish. (Thesis). University of Salford

Introduction: Fluoride is widely used as a method of reducing caries and while much is known about the processes involved in enamel remineralisation the effects of fluoride on indigenous biofilms in vivo are unclear. Aims: The aim of this study was t... Read More about Dental biofilm formation in young children and the long term effects of fluoride varnish.

Novel fusion proteins based on recombinant lectins for delivery of a cytotoxic peptide specifically to cancer cells
Thesis
Mohammed, S. Novel fusion proteins based on recombinant lectins for delivery of a cytotoxic peptide specifically to cancer cells. (Thesis). University of Salford

One of the most common post-translational modifications is covalent attachment of carbohydrates to proteins. At the cell surface, molecular recognition events involved in cancer metastasis are mediated by sugar moieties of glycoproteins. Evidence fro... Read More about Novel fusion proteins based on recombinant lectins for delivery of a cytotoxic peptide specifically to cancer cells.

In vitro analysis of volatile organic compounds in search of potential biomarkers of lung cancer
Thesis
Schmidt, K. (in press). In vitro analysis of volatile organic compounds in search of potential biomarkers of lung cancer. (Thesis). University of Salford

Lung cancer is a leading cause of death from cancer worldwide. An early diagnosis and appropriate treatment are crucial in reducing mortality among people suffering from the disease. Therefore, one of the main focuses of lung cancer studies is on a... Read More about In vitro analysis of volatile organic compounds in search of potential biomarkers of lung cancer.

Antimicrobial evaluation of selected medicinal plants using molecular approach
Thesis
Qaddoori, A. G. Antimicrobial evaluation of selected medicinal plants using molecular approach. (Thesis). University of Salford

Resistance to antibiotics is one of the greatest menaces to the success of modern medication. It has lately become more dangerous because we can no longer be certain that any antibiotic chosen will work and because of the emergence of multidrug res... Read More about Antimicrobial evaluation of selected medicinal plants using molecular approach.

Use of molecular and bioinformatics tools for developing methods of epidemiological identification of trypanosomes
Thesis
Adwik, G. (in press). Use of molecular and bioinformatics tools for developing methods of epidemiological identification of trypanosomes. (Thesis). University of Salford

Human African trypanosomiasis (HAT), also known as sleeping sickness, has been a major health problem for populations in Africa caused by the Trypanosoma brucei spp parasite. Although, the current number of the reported cases is on the decrease, more... Read More about Use of molecular and bioinformatics tools for developing methods of epidemiological identification of trypanosomes.

Genetic diversity of African isolates of Toxoplasma gondii
Thesis
Alruhaili, M. (in press). Genetic diversity of African isolates of Toxoplasma gondii. (Thesis). University of Salford

Toxoplasma gondii is an intracellular protozoan parasite and has the ability to infect all warm-blooded animals, including humans. While the three clonal lineages of T. gondii (I, II and III) predominate in North America and Europe, strains from ot... Read More about Genetic diversity of African isolates of Toxoplasma gondii.

Canine echinococcosis in Kyrgyzstan : detection, diagnosis, and dynamics
Thesis
Mastin, A. (in press). Canine echinococcosis in Kyrgyzstan : detection, diagnosis, and dynamics. (Thesis). University of Salford

Human echinococcosis is an increasing public health issue in Kyrgyzstan, where Echinococcus granulosus and Echinococcus multilocularis are coendemic and domestic dogs are considered the primary source of human infection. A control scheme based upon d... Read More about Canine echinococcosis in Kyrgyzstan : detection, diagnosis, and dynamics.

The use of molecular tools for Pan-Trypanosoma analysis and epigenetics of the host
Thesis
Ideozu, E. (in press). The use of molecular tools for Pan-Trypanosoma analysis and epigenetics of the host. (Thesis). University of Salford Manchester

Trypanosomes are a major cause of disease and death in both animal and human populations. Resistance or susceptibility to African trypanosomes has been associated with TLR9 gene. Hence, the primary objectives of this study were to apply molecular... Read More about The use of molecular tools for Pan-Trypanosoma analysis and epigenetics of the host.

An investigation into the diversity of genes of the innate immune system in the European Badger (Meles meles) and possible associations with trypanosome infection
Thesis
Whiteoak, A. (in press). An investigation into the diversity of genes of the innate immune system in the European Badger (Meles meles) and possible associations with trypanosome infection. (Dissertation). University of Salford

Toll-like receptor (TLR) genes encode for conserved proteins of the innate immune system which trigger pathways in response to pathogen invasion by recognising molecules essential for endoparasite survival. An endoparasite lives within the host and r... Read More about An investigation into the diversity of genes of the innate immune system in the European Badger (Meles meles) and possible associations with trypanosome infection.