G protein-coupled receptors at the crossroad between physiologic and pathologic angiogenesis : old paradigms and emerging concepts (2017)
Journal Article
De Francesco, E., Sotgia, F., Clarke, R., Lisanti, M., & Maggiolini, M. (2017). G protein-coupled receptors at the crossroad between physiologic and pathologic angiogenesis : old paradigms and emerging concepts. International Journal of Molecular Sciences, 18(12), https://doi.org/10.3390/ijms18122713

G protein-coupled receptors (GPCRs) have been implicated in transmitting signals across the extra- and intra-cellular compartments, thus allowing environmental stimuli to elicit critical biological responses. As GPCRs can be activated by an extensive... Read More about G protein-coupled receptors at the crossroad between physiologic and pathologic angiogenesis : old paradigms and emerging concepts.

The effect of normal human serum on the mouse trypanosome Trypanosoma musculi in vitro and in vivo (2017)
Journal Article
Zhang, X., Hong, X., Li, S., Lai, D., Hide, G., Lun, Z., & Wen, Y. (2018). The effect of normal human serum on the mouse trypanosome Trypanosoma musculi in vitro and in vivo. Experimental Parasitology, 184, 115-120. https://doi.org/10.1016/j.exppara.2017.12.005

Trypanosoma musculi, a common blood flagellate found in mice, is similar in morphology and life cycle to the rat trypanosome T. lewisi. Both species belong to the subgenus Herpetosoma, and as T. lewisi has recently been shown to be a zoonotic pathoge... Read More about The effect of normal human serum on the mouse trypanosome Trypanosoma musculi in vitro and in vivo.

The human DNA glycosylases NEIL1 and NEIL3 excise psoralen-induced DNA-DNA cross-links in a four-stranded DNA structure (2017)
Journal Article
Martin, P., Couve, S., Zutterling, C., Albelazi, M., Groisman, R., Matkarimov, B., …Saparbaev, M. (2017). The human DNA glycosylases NEIL1 and NEIL3 excise psoralen-induced DNA-DNA cross-links in a four-stranded DNA structure. Scientific reports, 7(17438), https://doi.org/10.1038/s41598-017-17693-4

Interstrand cross-links (ICLs) are highly cytotoxic DNA lesions that block DNA replication and transcription by preventing strand separation. Previously, we demonstrated that the bacterial and human DNA glycosylases Nei and NEIL1 excise unhooked pso... Read More about The human DNA glycosylases NEIL1 and NEIL3 excise psoralen-induced DNA-DNA cross-links in a four-stranded DNA structure.

GPER mediates the angiocrine actions induced by IGF1 through the HIF-1α/VEGF pathway in the breast tumor microenvironment (2017)
Journal Article
De Francesco, E., Sims, A., Maggiolini, M., Sotgia, F., Lisanti, M., & Clarke, R. (2017). GPER mediates the angiocrine actions induced by IGF1 through the HIF-1α/VEGF pathway in the breast tumor microenvironment. Breast Cancer Research, 19(1), 129. https://doi.org/10.1186/s13058-017-0923-5

The G protein estrogen receptor GPER/GPR30 mediates estrogen action in breast cancer cells as well as in breast cancer-associated fibroblasts (CAFs), which are key components of microenvironment driving tumor progression. GPER is a transcriptional ta... Read More about GPER mediates the angiocrine actions induced by IGF1 through the HIF-1α/VEGF pathway in the breast tumor microenvironment.

Overview of a current ethical challenge in anti-doping (2017)
Book Chapter
Miah, A. (2017). Overview of a current ethical challenge in anti-doping. In A. Rigozzi, E. Wisnosky, & B. Quinn (Eds.), The proceedings of the 2017 Macolin Anti-Doping Summit: A fresh look at the science, legal and policy aspects of anti-doping (159-170). Bern: Editions WebLaw

Campylobacter jejuni transcriptome changes during loss of culturability in water (2017)
Journal Article
Bronowski, C., Mustafa, K., Goodhead, I., James, C., Nelson, C., Lucaci, A., …Winstanley, C. (2017). Campylobacter jejuni transcriptome changes during loss of culturability in water. PLoS ONE, 12(11), e0188936. https://doi.org/10.1371/journal.pone.0188936

Background: Water serves as a potential reservoir for Campylobacter, the leading cause of bacterial gastroenteritis in humans. However, little is understood about the mechanisms underlying variations in survival characteristics between different st... Read More about Campylobacter jejuni transcriptome changes during loss of culturability in water.

From basics to clinic : Cancer Nanotechnology (2017)
Journal Article
Currell, F., Curley, S., Krpetic, Z., & Bellringer, M. (2017). From basics to clinic : Cancer Nanotechnology. Cancer Nanotechnology, 8(8), https://doi.org/10.1186/s12645-017-0033-1

Insight into glucocorticoid receptor signalling through interactome model analysis (2017)
Journal Article
Bakker, E., Tian, K., Mutti, L., Demonacos, C., Schwartz, J., & Krstic-Demonacos, M. (2017). Insight into glucocorticoid receptor signalling through interactome model analysis. PLoS Computational Biology, 13(11), https://doi.org/10.1371/journal.pcbi.1005825

Glucocorticoid hormones (GCs) are used to treat a variety of diseases because of their potent anti-inflammatory effect and their ability to induce apoptosis in lymphoid malignancies through the glucocorticoid receptor (GR). Despite ongoing research,... Read More about Insight into glucocorticoid receptor signalling through interactome model analysis.

Corticosteroid treatment is associated with increased filamentous fungal burden in allergic fungal disease (2017)
Journal Article
allergic fungal disease. Journal of Allergy and Clinical Immunology, 142(2), 407-414. https://doi.org/10.1016/j.jaci.2017.09.039

Background Allergic diseases caused by fungi are common. The best understood conditions are allergic bronchopulmonaryaspergillosis (ABPA) and severe asthma with fungal sensitisation (SAFS). Our knowledge of the fungal microbiome (mycobiome) is li... Read More about Corticosteroid treatment is associated with increased filamentous fungal burden in allergic fungal disease.

miRNAs in bone metastasis (2017)
Journal Article
Cheung, D., Buzzetti, M., & Di Leva, G. (2017). miRNAs in bone metastasis. Expert Review of Endocrinology and Metabolism, 12(6), 451-461. https://doi.org/10.1080/17446651.2017.1383893

Introduction: Bone metastasis is one of the most common forms of metastasis from a number of different primary carcinomas. MicroRNAs (miRNAs) are short, endogenous RNAs that negatively regulate gene expression to control essential pathways, including... Read More about miRNAs in bone metastasis.

Pilot study demonstrating metabolic and anti-proliferative effects of in vivo anti-oxidant supplementation with N-Acetylcysteine in Breast Cancer (2017)
Journal Article
Monti, D., Sotgia, F., Whitaker-Menezes, D., Tuluc, M., Birbe, R., Berger, A., …Martinez-Outschoorn, U. (2017). Pilot study demonstrating metabolic and anti-proliferative effects of in vivo anti-oxidant supplementation with N-Acetylcysteine in Breast Cancer. Seminars in Oncology, 44(3), 226-232. https://doi.org/10.1053/j.seminoncol.2017.10.001

Background High oxidative stress as defined by hydroxyl and peroxyl activity is often found in the stroma of human breast cancers. Oxidative stress induces stromal catabolism, which promotes cancer aggressiveness. Stromal cells exposed to oxidativ... Read More about Pilot study demonstrating metabolic and anti-proliferative effects of in vivo anti-oxidant supplementation with N-Acetylcysteine in Breast Cancer.

Interleukin-6 and Interleukin-10 concentrations as predictors of patient outcome following major traumatic injury (2017)
Thesis
Jones, M. Interleukin-6 and Interleukin-10 concentrations as predictors of patient outcome following major traumatic injury. (Dissertation). University of Salford

Trauma is one of the main causes of death worldwide, accounting for 4.8 million deaths per year. This death rate has led to trauma being classed as the top cause of death for males, aged between fifteen and twenty-nine. More recently, however, the... Read More about Interleukin-6 and Interleukin-10 concentrations as predictors of patient outcome following major traumatic injury.

Mitoketoscins : novel mitochondrial inhibitors for targeting ketone metabolism in cancer stem cells (CSCs). (2017)
Journal Article
Ozsvari, B., Sotgia, F., Simmons, K., Trowbridge, R., Foster, R., & Lisanti, M. (2017). Mitoketoscins : novel mitochondrial inhibitors for targeting ketone metabolism in cancer stem cells (CSCs). Oncotarget, 8(45), 78340-78350. https://doi.org/10.18632/oncotarget.21259

Previous studies have now well-established that epithelial cancer cells can utilize ketone bodies (3-hydroxybutyrate and aceto-acetate) as mitochondrial fuels, to actively promote tumor growth and metastatic dissemination. The two critical metabolic... Read More about Mitoketoscins : novel mitochondrial inhibitors for targeting ketone metabolism in cancer stem cells (CSCs)..

Characterisation of a novel bioactive complex polysaccharide from a marine invertebrate with potent anticancer and antimalarial activities (2017)
Thesis
Khurshid, C. A. Characterisation of a novel bioactive complex polysaccharide from a marine invertebrate with potent anticancer and antimalarial activities. (Thesis). ELS

Considerable excitement has been generated by the discovery of active compounds from marine organisms. These compounds have a remarkable role in cancer treatment, with fewer side effects on general health. Sulphated glycosaminoglycan (GAGs) are prese... Read More about Characterisation of a novel bioactive complex polysaccharide from a marine invertebrate with potent anticancer and antimalarial activities.

Nitric oxide blocks the development of the human parasite Schistosoma japonicum (2017)
Journal Article
Shen, J., Lai, D., Wilson, R., Chen, Y., Wang, L., Yu, Z., …Lun, Z. (2017). Nitric oxide blocks the development of the human parasite Schistosoma japonicum. Proceedings of the National Academy of Sciences of the United States of America, 114(38), 10214-10219. https://doi.org/10.1073/pnas.1708578114

Human schistosomiasis, caused by Schistosoma species, is a major public health problem affecting more than 700 million people in 78 countries, with over 40 mammalian host reservoir species complicating the transmission ecosystem. The primary cause of... Read More about Nitric oxide blocks the development of the human parasite Schistosoma japonicum.

The effect of environmental stress and selective glucocorticoid receptor modulators on chicken and human leukaemia cells (2017)
Thesis
Al-ibadi, I. The effect of environmental stress and selective glucocorticoid receptor modulators on chicken and human leukaemia cells. (Thesis). University of Salford

Glucocorticoids (GCs) play important functions in human physiology, and are commonly prescribed anti-inflammatory and immunosuppressive drugs. GCs are used in treatment of childhood acute lymphocytic leukemia (ALL), however resistance to therapy and... Read More about The effect of environmental stress and selective glucocorticoid receptor modulators on chicken and human leukaemia cells.

Assessment of the efficacy of BTI Larvicide, VectoBac 12AS® (BTI AM65-52) against “nuisance” flies at water treatment plants in North West England (2017)
Thesis
Wenjere, S. Assessment of the efficacy of BTI Larvicide, VectoBac 12AS® (BTI AM65-52) against “nuisance” flies at water treatment plants in North West England. (Dissertation). University of Salford

In treating wastewater using percolating filters, nature employs diverse biota, which includes nematoceran larvae, to sustain filter function. This study sought to generate evidence on the efficacy of a Bacillus thuringiensis var. israelensis-deriv... Read More about Assessment of the efficacy of BTI Larvicide, VectoBac 12AS® (BTI AM65-52) against “nuisance” flies at water treatment plants in North West England.

Stromal cyclin D1 promotes heterotypic immune signaling and breast cancer growth (2017)
Journal Article
Pestell, T., Jiao, X., Kumar, M., Peck, A., Prisco, M., Deng, S., …Pestell, R. (2017). Stromal cyclin D1 promotes heterotypic immune signaling and breast cancer growth. Oncotarget, 8, 81754-81775. https://doi.org/10.18632/oncotarget.19953

The cyclin D1 gene encodes the regulatory subunit of a holoenzyme that drives cell autonomous cell cycle progression and proliferation. Herein we show cyclin D1 abundance is increased >30-fold in the stromal fibroblasts of patients with invasive brea... Read More about Stromal cyclin D1 promotes heterotypic immune signaling and breast cancer growth.

Nanoethics, science communication, and a fourth model for public engagement (2017)
Journal Article
Miah, A. (2017). Nanoethics, science communication, and a fourth model for public engagement. NanoEthics, 11(2), 139-152. https://doi.org/10.1007/s11569-017-0302-9

This paper develops a fourth model of public engagement with science, grounded in the principle of nurturing scientific agency through online participatory bioethics. It argues that social media is an effective device through which to enable such eng... Read More about Nanoethics, science communication, and a fourth model for public engagement.

Immunotherapy advances for mesothelioma treatment (2017)
Journal Article
Bakker, E., Guazzelli, A., Ashtiani, F., Demonacos, C., Krstic-Demonacos, M., & Mutti, L. (2017). Immunotherapy advances for mesothelioma treatment. Expert Review of Anticancer Therapy, 17(9), 799-814. https://doi.org/10.1080/14737140.2017.1358091

Introduction: Mesothelioma is a rare type of cancer that is strongly tied to asbestos exposure. Despite application of different modalities such as chemotherapy, radiotherapy and surgery, patient prognosis remains very poor and therapies are ineffect... Read More about Immunotherapy advances for mesothelioma treatment.