The ER-alpha mutation Y537S confers Tamoxifen-resistance via enhanced mitochondrial metabolism, glycolysis and Rho-GDI/PTEN signaling : implicating TIGAR in somatic resistance to endocrine therapy (2018)
Journal Article
Fiorillo, M., Sanchez-Alvarez, R., Sotgia, F., & Lisanti, M. (2018). The ER-alpha mutation Y537S confers Tamoxifen-resistance via enhanced mitochondrial metabolism, glycolysis and Rho-GDI/PTEN signaling : implicating TIGAR in somatic resistance to endocrine therapy. Aging, 10(12), 4000-4023. https://doi.org/10.18632/aging.101690

Naturally-occurring somatic mutations in the estrogen receptor gene (ESR1) have been previously implicated in the clinical development of resistance to hormonal therapies, such as Tamoxifen. For example, the somatic mutation Y537S has been specifical... Read More about The ER-alpha mutation Y537S confers Tamoxifen-resistance via enhanced mitochondrial metabolism, glycolysis and Rho-GDI/PTEN signaling : implicating TIGAR in somatic resistance to endocrine therapy.

Landscape structure affects the prevalence and distribution of a tick-borne zoonotic pathogen (2018)
Journal Article
Millins, C., Dickinson, E., Isakovic, P., Gilbert, L., Wojciechowska, A., Paterson, V., …Biek, R. (2018). Landscape structure affects the prevalence and distribution of a tick-borne zoonotic pathogen. Parasites and Vectors, 11(2018), 621. https://doi.org/10.1186/s13071-018-3200-2

Background Landscape structure can affect pathogen prevalence and persistence with consequences for human and animal health. Few studies have examined how reservoir host species traits may interact with landscape structure to alter pathogen communi... Read More about Landscape structure affects the prevalence and distribution of a tick-borne zoonotic pathogen.

The role of the copper oxidation state in the electrocatalytic reduction of CO2 into valuable hydrocarbons (2018)
Journal Article
Velasco-Vélez, J., Jones, T., Gao, D., Carbonio, E., Arrigo, R., Hsu, C., …Chuang, C. (2018). The role of the copper oxidation state in the electrocatalytic reduction of CO2 into valuable hydrocarbons. ACS sustainable chemistry & engineering, 7(1), 1485-1492. https://doi.org/10.1021/acssuschemeng.8b05106

Redox-active copper catalysts with accurately prepared oxidation states (Cu0, Cu+ and Cu2+) and high selectivity to C2 hydrocarbon formation, from electrocatalytic cathodic reduction of CO2, were fabricated and characterized. The electrochemically pr... Read More about The role of the copper oxidation state in the electrocatalytic reduction of CO2 into valuable hydrocarbons.

Azithromycin and Roxithromycin define a new family of “senolytic” drugs that target senescent human fibroblasts (2018)
Journal Article
Ozsvari, B., Nuttall, J., Sotgia, F., & Lisanti, M. (2018). Azithromycin and Roxithromycin define a new family of “senolytic” drugs that target senescent human fibroblasts. Aging, 10(11), 3294-3307. https://doi.org/10.18632/aging.101633

Here, we employed a “senolytic” assay system as a screening tool, with the goal of identifying and repurposing FDA-approved antibiotics, for the targeting of the senescent cell population. Briefly, we used two established human fibroblast cell lines... Read More about Azithromycin and Roxithromycin define a new family of “senolytic” drugs that target senescent human fibroblasts.

Live single cell analysis using synchrotron FTIR microspectroscopy: development of a simple dynamic flow system for prolonged sample viability (2018)
Journal Article
Doherty, J., Raoof, A., Hussain, A., Wolna, M., Cinque, G., Brown, M., …Denbigh, J. (2019). Live single cell analysis using synchrotron FTIR microspectroscopy: development of a simple dynamic flow system for prolonged sample viability. Analyst, 144(3), 997-1007. https://doi.org/10.1039/C8AN01566J

Synchrotron radiation Fourier transform infrared microspectroscopy (SR-microFTIR) of live biological cells has the potential to provide far greater biochemical and morphological detail than equivalent studies using dehydrated, chemically-fixed single... Read More about Live single cell analysis using synchrotron FTIR microspectroscopy: development of a simple dynamic flow system for prolonged sample viability.

Genotyping of Toxoplasma gondii from pigs in Yucatan, Mexico (2018)
Journal Article
Cubas-Atienzar, A., Hide, G., Jiménez-Coello, M., Ortega-Pacheco, A., & Smith, J. (2018). Genotyping of Toxoplasma gondii from pigs in Yucatan, Mexico. Veterinary Parasitology: Regional Studies and Reports, 14, 191-199. https://doi.org/10.1016/j.vprsr.2018.10.009

Toxoplasmosis is a zoonotic disease of worldwide distribution. The parasite exhibits strong geographical patterns of strain variation with contrasting high levels of diversity across South America and restricted variation across North America. Litt... Read More about Genotyping of Toxoplasma gondii from pigs in Yucatan, Mexico.

p53 modeling as a route to mesothelioma patients' stratification and novel therapeutic identification (2018)
Journal Article
Tian, K., Bakker, E., Hussain, M., Guazzelli, A., Alhebshi, H., Meysami, P., …Krstic-Demonacos, M. (2018). p53 modeling as a route to mesothelioma patients' stratification and novel therapeutic identification. Journal of Translational Medicine, 16(282), https://doi.org/10.1186/s12967-018-1650-0

Background: Malignant pleural mesothelioma (MPM) is an orphan disease that is difficult to treat using traditional chemotherapy, an approach which has been effective in other types of cancer. Most chemotherapeutics cause DNA damage leading to cell de... Read More about p53 modeling as a route to mesothelioma patients' stratification and novel therapeutic identification.

Doxycycline, an inhibitor of mitochondrial biogenesis, effectively reduces cancer stem cells (CSCs) in early breast cancer patients : a clinical pilot study (2018)
Journal Article
Scatena, C., Roncella, M., Di Paolo, A., Aretini, P., Menicagli, M., Fanelli, G., …Naccarato, A. (2018). Doxycycline, an inhibitor of mitochondrial biogenesis, effectively reduces cancer stem cells (CSCs) in early breast cancer patients : a clinical pilot study. Frontiers in Oncology, 8(452), https://doi.org/10.3389/fonc.2018.00452

Background and objectives: Cancer stem cells (CSCs) have been implicated in tumor initiation, recurrence, metastatic spread and poor survival in multiple tumor types, breast cancers included. CSCs selectively overexpress key mitochondrial-related pro... Read More about Doxycycline, an inhibitor of mitochondrial biogenesis, effectively reduces cancer stem cells (CSCs) in early breast cancer patients : a clinical pilot study.

Detection and analysis of spin trapped radical adducts using thermal desorption gas chromatography mass spectrometry (TD-GC-MS) (2018)
Thesis
Manzoor, K. (2018). Detection and analysis of spin trapped radical adducts using thermal desorption gas chromatography mass spectrometry (TD-GC-MS). (Thesis). University of Salford

Certain oxygen free radicals are produced constantly in cells by metabolism and exogenous agents. Some, such as the hydroxyl radical, may react with various biomolecules like DNA, lipids or proteins, and thus be involved in the pathogenesis of var... Read More about Detection and analysis of spin trapped radical adducts using thermal desorption gas chromatography mass spectrometry (TD-GC-MS).

A mitochondrial based oncology platform for targeting cancer stem cells (CSCs) : MITO-ONC-RX (2018)
Journal Article
Sotgia, F., Ozsvari, B., Fiorillo, M., De Francesco, E., Bonuccelli, G., & Lisanti, M. (2018). A mitochondrial based oncology platform for targeting cancer stem cells (CSCs) : MITO-ONC-RX. Cell Cycle, 17(17), 2091-2100. https://doi.org/10.1080/15384101.2018.1515551

Here, we wish to propose a new systematic approach to cancer therapy, based on the targeting of mitochondrial metabolism, especially in cancer stem cells (CSCs). In the future, we envision that anti-mitochondrial therapy would ultimately be practiced... Read More about A mitochondrial based oncology platform for targeting cancer stem cells (CSCs) : MITO-ONC-RX.

Matcha green tea (MGT) inhibits the propagation of cancer stem cells (CSCs), by targeting mitochondrial metabolism, glycolysis and multiple cell signalling pathways (2018)
Journal Article
Bonuccelli, G., Sotgia, F., & Lisanti, M. (2018). Matcha green tea (MGT) inhibits the propagation of cancer stem cells (CSCs), by targeting mitochondrial metabolism, glycolysis and multiple cell signalling pathways. Aging, 10(8), 1867-1883. https://doi.org/10.18632/aging.101483

Matcha green tea (MGT) is a natural product that is currently used as a dietary supplement and may have significant anti-cancer properties. However, the molecular mechanism(s) underpinning its potential health benefits remain largely unknown. Here, w... Read More about Matcha green tea (MGT) inhibits the propagation of cancer stem cells (CSCs), by targeting mitochondrial metabolism, glycolysis and multiple cell signalling pathways.

SPARC 2018 Internationalisation and collaboration : Salford postgraduate annual research conference book of abstracts (2018)
Book
Abdu, Y., Abduljawad, S., Abdullahi, R., Abraham, A., Adamu, H., Adeleke, A., …Usman, B. (2018). T. Ireland (Ed.), SPARC 2018 Internationalisation and collaboration : Salford postgraduate annual research conference book of abstracts. Salford, UK: University of Salford

Welcome to the Book of Abstracts for the 2018 SPARC conference. This year we not only celebrate the work of our PGRs but also the launch of our Doctoral School, which makes this year’s conference extra special. Once again we have received a tremendou... Read More about SPARC 2018 Internationalisation and collaboration : Salford postgraduate annual research conference book of abstracts.

β3-adrenoceptor stimulation of perivascular adipocytes leads to increased fat cell-derived nitric oxide and vascular relaxation in small arteries (2018)
Journal Article
Bussey, C., Withers, S., Saxton, S., Bodagh, N., Aldous, R., & Heagerty, A. (2018). β3-adrenoceptor stimulation of perivascular adipocytes leads to increased fat cell-derived nitric oxide and vascular relaxation in small arteries. British Journal of Pharmacology, 175(18), 2685-3698. https://doi.org/10.1111/bph.14433

BACKGROUND AND PURPOSE In response to norepinephrine healthy perivascular adipose tissue (PVAT) exerts an anticontractile effect on adjacent small arterial tissue. Organ bath solution transfer experiments have demonstrated the release of PVAT-deriv... Read More about β3-adrenoceptor stimulation of perivascular adipocytes leads to increased fat cell-derived nitric oxide and vascular relaxation in small arteries.

Increased optical pathlength through aqueous media for the infrared microanalysis of live cells (2018)
Journal Article
Doherty, J., Zhang, Z., Wehbe, K., Cinque, G., Gardner, P., & Denbigh, J. (2018). Increased optical pathlength through aqueous media for the infrared microanalysis of live cells. Analytical and Bioanalytical Chemistry, 410(23), 5779-5789. https://doi.org/10.1007/s00216-018-1188-2

The study of live cells using Fourier transform infrared spectroscopy (FTIR) and FTIR microspectroscopy (FT-IRMS) intrinsically yields more information about cell metabolism than comparable experiments using dried or chemically fixed samples. There a... Read More about Increased optical pathlength through aqueous media for the infrared microanalysis of live cells.

Investigation into the genetic diversity in toll-like receptors 2 and 4 in the European badger Meles meles (2018)
Journal Article
Whiteoak, A., Ideozu, J., Alkathiry, H., Tomlinson, A., Delahay, R., Cowen, S., …Hide, G. (2018). Investigation into the genetic diversity in toll-like receptors 2 and 4 in the European badger Meles meles. Research in Veterinary Science, 119, 228-231. https://doi.org/10.1016/j.rvsc.2018.06.020

The Toll-like receptor (TLR) genes are a conserved family of genes central to the innate immune response to pathogen infection. They encode receptor proteins, recognise pathogen associated molecular patterns (PAMPs) and trigger initial immune respons... Read More about Investigation into the genetic diversity in toll-like receptors 2 and 4 in the European badger Meles meles.

Microwave assisted synthesis of novel bis-flavone dimers as new anticancer agents (2018)
Journal Article
Ragazzon, P., McGown, A., Ragazzon-Smith, A., Hadfield, J., & Potgetier, H. (2018). Microwave assisted synthesis of novel bis-flavone dimers as new anticancer agents. Letters in Organic Chemistry, 16(1), 66-75. https://doi.org/10.2174/1570178615666180621094529

In this study we describe a microwave based click chemistry method used to prepare a family of novel bis-flavone dimers. The substituted 7-hydroxy and 4’-hydroxy flavonoids were linked through a triazole ring. The compounds were easily synthesized an... Read More about Microwave assisted synthesis of novel bis-flavone dimers as new anticancer agents.

Isolation and composition analysis of bioactive glycosaminoglycans from whelk (2018)
Journal Article
Khurshid, C., & Pye, D. (2018). Isolation and composition analysis of bioactive glycosaminoglycans from whelk. Marine Drugs, 16(5), 0171. https://doi.org/10.3390/md16050171

Glycosaminoglycans (GAGs) are found covalently attached to proteins, which create conjugates known as proteoglycans. GAGs have remarkable biological activity as co-receptors for a variety of growth factors, cytokines, and chemokines. The present stud... Read More about Isolation and composition analysis of bioactive glycosaminoglycans from whelk.

Functional molecules in mesothelial to mesenchymal transition revealed by transcriptome analyses (2018)
Journal Article
Namvar, S., Woolf, A., Zeef, L., Wilm, T., Wilm, B., & Herrick, S. (2018). Functional molecules in mesothelial to mesenchymal transition revealed by transcriptome analyses. Journal of Pathology, 245(4), 491-501. https://doi.org/10.1002/path.5101

Peritoneal fibrosis is a common complication of abdominal and pelvic surgery, and can also be triggered by peritoneal dialysis, resulting in treatment failure. In these settings, fibrosis is driven by activated myofibroblasts that are considered to b... Read More about Functional molecules in mesothelial to mesenchymal transition revealed by transcriptome analyses.

Novel internal regulators and candidate miRNAs within miR-379/miR-656 miRNA cluster can alter cellular phenotype of human glioblastoma (2018)
Journal Article
Nayak, S., Aich, M., Kumar, A., Sengupta, S., Bajad, P., Dhapola, P., …Sarkar, C. (2018). Novel internal regulators and candidate miRNAs within miR-379/miR-656 miRNA cluster can alter cellular phenotype of human glioblastoma. Scientific reports, 8(2018), #7673. https://doi.org/10.1038/s41598-018-26000-8

Clustered miRNAs can affect functioning of downstream pathways due to possible coordinated function. We observed 78-88% of the miR-379/miR-656 cluster (C14MC) miRNAs were downregulated in three sub-types of diffuse gliomas, which was also corrobora... Read More about Novel internal regulators and candidate miRNAs within miR-379/miR-656 miRNA cluster can alter cellular phenotype of human glioblastoma.

Cancer stem cells (CSCs) : metabolic strategies for their identification and eradication (2018)
Journal Article
De Francesco, E., Sotgia, F., & Lisanti, M. (2018). Cancer stem cells (CSCs) : metabolic strategies for their identification and eradication. Biochemical Journal, 475(9), 1611-1634. https://doi.org/10.1042/BCJ20170164

Phenotypic and functional heterogeneity is one of the most relevant features of cancer cells within different tumor types and is responsible for treatment failure. Cancer stem cells (CSCs) are a population of cells with stem cell-like properties that... Read More about Cancer stem cells (CSCs) : metabolic strategies for their identification and eradication.