Microwave assisted synthesis of novel bis-flavone dimers as new anticancer agents

Ragazzon, PA; McGown, A; Ragazzon-Smith, AH; Hadfield, JA; Potgetier, H

Abstract

In this study we describe a microwave based click chemistry method used to prepare a family of novel bis-flavone dimers. The substituted 7-hydroxy and 4’-hydroxy flavonoids were linked through a triazole ring. The compounds were easily synthesized and purified in high yields. The bis-flavonoids were tested on different cell lines including HCT116, HepG2, MCF7 and MOLT-4. Several analogues showed to have anticancer activity with IC50 values in the range of 20-60 µM. Flavonoids are known for their anticancer properties and this method provides the basis for new medicinal structures.

• Journal Article Type: Article
• Acceptance Date: Jun 14, 2018
• Online Publication Date: Jun 26, 2018
• Publication Date: Jun 26, 2018
• Deposit Date: Jun 26, 2018
• Publicly Available Date: Jun 26, 2019
• Journal: Letters in Organic Chemistry
• Print ISSN: 1570-1786
• Publisher: Bentham Science Publishers
• Volume: 16
• Issue: 1
• Pages: 66-75
• DOI: https://doi.org/10.2174/1570178615666180621094529
• Publisher URL: https://doi.org/10.2174/1570178615666180621094529
• Related Public URLs: https://benthamscience.com/journals/letters-in-organic-chemistry/#top