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Microwave assisted synthesis of novel bis-flavone dimers as new anticancer agents

Ragazzon, PA; McGown, A; Ragazzon-Smith, AH; Hadfield, JA; Potgetier, H

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Authors

PA Ragazzon

A McGown

AH Ragazzon-Smith

JA Hadfield

H Potgetier



Abstract

In this study we describe a microwave based click chemistry method used to prepare a family of novel bis-flavone dimers. The substituted 7-hydroxy and 4’-hydroxy flavonoids were linked through a triazole ring. The compounds were easily synthesized and purified in high yields. The bis-flavonoids were tested on different cell lines including HCT116, HepG2, MCF7 and MOLT-4. Several analogues showed to have anticancer activity with IC50 values in the range of 20-60 µM. Flavonoids are known for their anticancer properties and this method provides the basis for new medicinal structures.

Citation

Ragazzon, P., McGown, A., Ragazzon-Smith, A., Hadfield, J., & Potgetier, H. (2018). Microwave assisted synthesis of novel bis-flavone dimers as new anticancer agents. Letters in Organic Chemistry, 16(1), 66-75. https://doi.org/10.2174/1570178615666180621094529

Journal Article Type Article
Acceptance Date Jun 14, 2018
Online Publication Date Jun 26, 2018
Publication Date Jun 26, 2018
Deposit Date Jun 26, 2018
Publicly Available Date Jun 26, 2019
Journal Letters in Organic Chemistry
Print ISSN 1570-1786
Electronic ISSN 1875-6255
Publisher Bentham Science Publishers
Volume 16
Issue 1
Pages 66-75
DOI https://doi.org/10.2174/1570178615666180621094529
Publisher URL https://doi.org/10.2174/1570178615666180621094529
Related Public URLs https://benthamscience.com/journals/letters-in-organic-chemistry/#top

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