Review of outcomes used in nutritional trials in Pediatric Critical Care (2020)
Journal Article
Ghandvi, K., Valla, F., & Tume, L. (2020). Review of outcomes used in nutritional trials in Pediatric Critical Care. Journal of Parenteral and Enteral Nutrition, 44(7), 1210-1219. https://doi.org/10.1002/jpen.1765

Background: Generating robust evidence within Pediatric Intensive Care (PIC) can be challenging because of low patient numbers and patient heterogeneity. Systematic reviews may overcome small study biases but are limited by lack of standardisation in... Read More about Review of outcomes used in nutritional trials in Pediatric Critical Care.

Optimising paediatric afferent component early warning systems : a hermeneutic systematic literature review and model development (2019)
Journal Article
Jacob, N., Moriarty, Y., Lloyd, A., Mann, M., Tume, L., Sefton, G., …Allen, D. (2019). Optimising paediatric afferent component early warning systems : a hermeneutic systematic literature review and model development. BMJ Open, 9(11), https://doi.org/10.1136/bmjopen-2018-028796

Objective: To identify the core components of successful early warning systems for detecting and initiating action in response to clinical deterioration in paediatric inpatients. Methods: A hermeneutic systematic literature review informed by tra... Read More about Optimising paediatric afferent component early warning systems : a hermeneutic systematic literature review and model development.

A survey examining the use of mechanical insufflation-exsufflation on adult intensive care units across the UK (2019)
Journal Article
adult intensive care units across the UK. Journal of the Intensive Care Society, 21(4), 283-289. https://doi.org/10.1177/1751143719870121

Introduction: Despite potential benefits, it is not known how widely physiotherapists use mechanical insufflation exsufflation devices on UK adult intensive care units. This survey aimed to describe mechanical insufflation-exsufflation use in UK adu... Read More about A survey examining the use of mechanical insufflation-exsufflation on adult intensive care units across the UK.

Gastric residual volume measurement in U.K. PICUs: a survey of practice* (2019)
Journal Article
U.K. PICUs: a survey of practice*. Pediatric Critical Care Medicine, 20(8), 707-713. https://doi.org/10.1097/PCC.0000000000001944

Objectives: Despite little evidence, the practice of routine measurement of gastric residual volume to guide both the initiation and delivery of enteral feeding in PICUs is widespread internationally. In light of increased scrutiny of the evidence... Read More about Gastric residual volume measurement in U.K. PICUs: a survey of practice*.

Nutritional status deterioration occurs frequently during children's ICU stay (2019)
Journal Article
Valla, F., Baudin, F., Gaillard Le Roux, B., Ford-Chessel, C., Gervet, E., Giraud, C., …Tume, L. (2019). Nutritional status deterioration occurs frequently during children's ICU stay. Pediatric Critical Care Medicine, 20(8), 714-721. https://doi.org/10.1097/PCC.0000000000001979

OBJECTIVES: Malnutrition and faltering growth at PICU admission have been related to suboptimal outcomes. However, little is known about nutritional status deterioration during PICU stay, as critical illness is characterized by a profound and comple... Read More about Nutritional status deterioration occurs frequently during children's ICU stay.

Parents’ prioritised outcomes for trials investigating treatments for paediatric severe infection : a qualitative synthesis (2019)
Journal Article
qualitative synthesis. Archives of Disease in Childhood, 104(11), 1077-1082. https://doi.org/10.1136/archdischild-2019-316807

Objective To identify parents’ prioritised outcomes by combining qualitative findings from two trial feasibility studies of interventions for paediatric suspected severe infection. Design Qualitative synthesis combining parent interview data fro... Read More about Parents’ prioritised outcomes for trials investigating treatments for paediatric severe infection : a qualitative synthesis.

Validity and effectiveness of paediatric early warning systems and track and trigger tools for identifying and reducing clinical deterioration in hospitalised children: a systematic review (2019)
Journal Article
review. BMJ Open, 9(5), e022105. https://doi.org/10.1136/bmjopen-2018-022105

Objective To assess (1) how well validated existing paediatric track and trigger tools (PTTT) are for predicting adverse outcomes in hospitalised children, and (2) how effective broader paediatric early warning systems are at reducing adverse out... Read More about Validity and effectiveness of paediatric early warning systems and track and trigger tools for identifying and reducing clinical deterioration in hospitalised children: a systematic review.

Priorities for nutrition research in pediatric critical care (2018)
Journal Article
Tume, L., Valla, F., Floh, A., Goday, P., Jotterand-Chapparo, C., Larsen, B., …Mehta, N. (2019). Priorities for nutrition research in pediatric critical care. Journal of Parenteral and Enteral Nutrition, 43(7), 853-862. https://doi.org/10.1002/jpen.1498

Background: Widespread variation exists in pediatric critical care nutrition practices, largely because of the scarcity of evidence to guide best practice recommendations. Objective: The objective of this paper was to develop a list of topics to be... Read More about Priorities for nutrition research in pediatric critical care.

Enteral feeding practices in infants with congenital heart disease across European PICUs : a European Society of Pediatric and Neonatal Intensive Care survey (2018)
Journal Article
Intensive Care survey. Pediatric Critical Care Medicine, 19(2), 137-144. https://doi.org/10.1097/PCC.0000000000001412

Objectives: To describe enteral feeding practices in pre and postoperative infants with congenital heart disease in European PICUs. Design: Cross-sectional electronic survey. Setting: European PICUs that admit infants with congenital heart disea... Read More about Enteral feeding practices in infants with congenital heart disease across European PICUs : a European Society of Pediatric and Neonatal Intensive Care survey.

Nutritional management of young infants presenting with acute bronchiolitis in Belgium, France and Switzerland: survey of current practices and documentary search of national guidelines worldwide (2018)
Journal Article
practices and documentary search of national guidelines worldwide. European Journal of Pediatrics, 178(3), 331-340. https://doi.org/10.1007/s00431-018-3300-1

Nutritional management of young infants presenting with acute bronchiolitis in Belgium, France and Switzerland: survey of current practices and documentary search of national guidelines worldwide Conclusion: practices were inconsistent among physic... Read More about Nutritional management of young infants presenting with acute bronchiolitis in Belgium, France and Switzerland: survey of current practices and documentary search of national guidelines worldwide.

Parent’s experiences of their child’s withdrawal syndrome: a driver for reciprocal nurse-parent partnership in withdrawal assessment (2018)
Journal Article
reciprocal nurse-parent partnership in withdrawal assessment. Intensive and Critical Care Nursing, 50, 71-78. https://doi.org/10.1016/j.iccn.2018.09.001

Withdrawal assessment in critically ill children is complicated by the reliance on non-specific behaviours and compounded when the child’s typical behaviours are unknown. The existing approach to withdrawal assessment assumes that nurses elicit the... Read More about Parent’s experiences of their child’s withdrawal syndrome: a driver for reciprocal nurse-parent partnership in withdrawal assessment.

A review of feeding intolerance in critically ill children (2018)
Journal Article
Tume, L., & Valla, F. (2018). A review of feeding intolerance in critically ill children. European Journal of Pediatrics, 177, 1675-1683. https://doi.org/10.1007/s00431-018-3229-4

Ensuring optimal nutrition is vital in critically ill children and enteral feeding is the main route of delivery in intensive care. Feeding intolerance is the most commonly cited reason amongst pediatric intensive care unit healthcare professionals... Read More about A review of feeding intolerance in critically ill children.

Routine gastric residual volume measurement and energy target achievement in the PICU : a comparison study (2017)
Journal Article
Tume, L., Bickerdike, A., Latten, L., Davies, S., Lefèvre, M., Nicolas, G., & Valla, F. (2017). Routine gastric residual volume measurement and energy target achievement in the PICU : a comparison study. European Journal of Pediatrics, 176(12), 1637-1644. https://doi.org/10.1007/s00431-017-3015-8

Critically ill children frequently fail to achieve adequate energy intake, and some care practices, such as the measurement of gastric residual volume (GRV), may contribute to this problem. We compared outcomes in two similar European Paediatric Inte... Read More about Routine gastric residual volume measurement and energy target achievement in the PICU : a comparison study.

Patterns of instability associated with endotracheal suctioning in infants with single-ventricle physiology (2017)
Journal Article
in infants with single-ventricle physiology. American Journal of Critical Care, 26(5), 288-394

Background In infants with single-ventricle physiology, endotracheal suctioning poses risks because of the instability between pulmonary and systemic blood flow. Objective To examine processes and adverse events associated with endotracheal sucti... Read More about Patterns of instability associated with endotracheal suctioning in infants with single-ventricle physiology.

Paediatric intensive care nurses’ decision-making around gastric residual volume measurement (2017)
Journal Article
volume measurement. Nursing in Critical Care, 22(5), 293-297. https://doi.org/10.1111/nicc.12304

Background: Measuring gastric residual volume (GRV) to guide enteral feeding is a common nursing practice in intensive care units, yet little evidence supports this practice. In addition, this practice has been shown to potentially contribute to ina... Read More about Paediatric intensive care nurses’ decision-making around gastric residual volume measurement.

Nursing judgement and decision-making using the Sedation Withdrawal Score (SWS) in children (2017)
Journal Article
Withdrawal Score (SWS) in children. Journal of Advanced Nursing, 73(10), 2327-2338. https://doi.org/10.1111/jan.13305

Aims: The aim of the study was to evaluate registered children’s nurses’ approaches to the assessment and management of withdrawal syndrome in children. Background: Assessment of withdrawal syndrome is undertaken following critical illness when th... Read More about Nursing judgement and decision-making using the Sedation Withdrawal Score (SWS) in children.

Mechanical ventilation, weaning practices, and decision making in European PICUs (2017)
Journal Article
Tume, L., Knebyer, M., Blackwood, B., & Rose, L. (2017). Mechanical ventilation, weaning practices, and decision making in European PICUs. Pediatric Critical Care Medicine, 18(4), https://doi.org/10.1097/PCC.0000000000001100

Objectives: This survey had three key objectives: 1) To describe responsibility for key ventilation and weaning decisions in European PICUs and explore variations across Europe; 2) To describe the use of protocols, spontaneous breathing trials, no... Read More about Mechanical ventilation, weaning practices, and decision making in European PICUs.

Pilot study comparing closed versus open tracheal suctioning in postoperative neonates and infants with complex congenital heart disease (2017)
Journal Article
infants with complex congenital heart disease. Pediatric Critical Care Medicine, 18(7), 647-654. https://doi.org/10.1097/PCC.0000000000001192

Objectives: To determine the hemodynamic effect of tracheal suction method in the first 36 hours after high-risk infant heart surgery on the PICU and to compare open and closed suctioning techniques. Design: Pilot randomized crossover study. Sett... Read More about Pilot study comparing closed versus open tracheal suctioning in postoperative neonates and infants with complex congenital heart disease.

Clinical recommendations for pain, sedation, withdrawal and delirium assessment in critically ill infants and children: an ESPNIC position statement for healthcare professionals (2016)
Journal Article
position statement for healthcare professionals. Intensive Care Medicine, 42(6), 972-986. https://doi.org/10.1007/s00134-016-4344-1

Background: This position statement provides clinical recommendations for the assessment of pain, level of sedation, iatrogenic withdrawal syndrome and delirium in critically ill infants and children. Admission to a neonatal or paediatric intensive... Read More about Clinical recommendations for pain, sedation, withdrawal and delirium assessment in critically ill infants and children: an ESPNIC position statement for healthcare professionals.

Pediatric critical care nursing research priorities — initiating international dialogue (2015)
Journal Article
priorities — initiating international dialogue. Pediatric Critical Care Medicine, 16(6), e174-e182. https://doi.org/10.1097/PCC.0000000000000446

Objective: To identify and prioritize research questions of concern to the practice of pediatric critical care nursing practice. Design: One-day consensus conference. By using a conceptual framework by Benner et al describing domains of practice i... Read More about Pediatric critical care nursing research priorities — initiating international dialogue.