The transplant rejection response involves neutrophil and macrophage adhesion-mediated trogocytosis and is regulated by NFATc3 (2024)
Journal Article
Zhao, S., Hu, Y., Yang, B., Zhang, L., Xu, M., Jiang, K., …Shen, J. (in press). The transplant rejection response involves neutrophil and macrophage adhesion-mediated trogocytosis and is regulated by NFATc3. Cell Death and Disease, 15(1), 75. https://doi.org/10.1038/s41419-024-06457-4

The anti-foreign tissue (transplant rejection) response, mediated by the immune system, has been the biggest obstacle to successful organ transplantation. There are still many enigmas regarding this process and some aspects of the underlying mechanis... Read More about The transplant rejection response involves neutrophil and macrophage adhesion-mediated trogocytosis and is regulated by NFATc3.

Prevalence of Eimeria Species, Detected by ITS1-PCR Immobilized on FTA Cards, in Future Laying Hens and Breeding Hens in Six Provinces in Northeastern Algeria (2024)
Journal Article
Ayadi, O., Djemai, S., & Hide, G. (2024). Prevalence of Eimeria Species, Detected by ITS1-PCR Immobilized on FTA Cards, in Future Laying Hens and Breeding Hens in Six Provinces in Northeastern Algeria. Acta parasitologica / Witold Stefański Institute of Parasitology, https://doi.org/10.1007/s11686-023-00773-z

Purpose Avian coccidiosis is an important and widely distributed disease that affects global agricultural economies through losses. In Algeria, there is limited epidemiological and ecological knowledge about this disease and this hinders implementat... Read More about Prevalence of Eimeria Species, Detected by ITS1-PCR Immobilized on FTA Cards, in Future Laying Hens and Breeding Hens in Six Provinces in Northeastern Algeria.

Macrophage-mediated trogocytosis contributes to destroying human schistosomes in a non-susceptible rodent host, Microtus fortis (2023)
Journal Article
Shen, J., Zhao, S., Peng, M., Li, Y., Zhang, L., Li, X., …Wu, Z. (in press). Macrophage-mediated trogocytosis contributes to destroying human schistosomes in a non-susceptible rodent host, Microtus fortis. Cell Discovery, 9(1), 101. https://doi.org/10.1038/s41421-023-00603-6

Schistosoma parasites, causing schistosomiasis, exhibit typical host specificity in host preference. Many mammals, including humans, are susceptible to infection, while the widely distributed rodent, Microtus fortis, exhibits natural anti-schistosome... Read More about Macrophage-mediated trogocytosis contributes to destroying human schistosomes in a non-susceptible rodent host, Microtus fortis.

Functional screening reveals Toxoplasma prenylated proteins required for endocytic trafficking and rhoptry protein sorting (2023)
Journal Article
Wang, Q., Sun, M., Tang, T., Lai, D., Liu, J., Maity, S., …Long, S. (2023). Functional screening reveals Toxoplasma prenylated proteins required for endocytic trafficking and rhoptry protein sorting. mBio, https://doi.org/10.1128/mbio.01309-23

In the apicomplexans, endocytosed cargos (e.g., hemoglobin) are trafficked to a specialized organelle for digestion. This follows a unique endocytotic process at the micropore/cytostome in these parasites. However, the mechanism underlying endocytic... Read More about Functional screening reveals Toxoplasma prenylated proteins required for endocytic trafficking and rhoptry protein sorting.

The Toxoplasma micropore mediates endocytosis for selective nutrient salvage from host cell compartments (2023)
Journal Article
Wan, W., Dong, H., Lai, D., Yang, J., He, K., Tang, X., …Long, S. (in press). The Toxoplasma micropore mediates endocytosis for selective nutrient salvage from host cell compartments. Nature communications, 14(1), 997. https://doi.org/10.1038/s41467-023-36571-4

Apicomplexan parasite growth and replication relies on nutrient acquisition from host cells, in which intracellular multiplication occurs, yet the mechanisms that underlie the nutrient salvage remain elusive. Numerous ultrastructural studies have doc... Read More about The Toxoplasma micropore mediates endocytosis for selective nutrient salvage from host cell compartments.

Investigation into the potential of using UV-treated sporulated oocysts of Eimeria tenella as a local solution to immunization of chickens against caecal coccidiosis (2023)
Journal Article
Djemai, S., Mekroud, A., Hide, G., Khelifi, D., & Bellil, I. (in press). Investigation into the potential of using UV-treated sporulated oocysts of Eimeria tenella as a local solution to immunization of chickens against caecal coccidiosis. Journal of Parasitic Diseases, https://doi.org/10.1007/s12639-022-01562-7

In this study, we aim to evaluate the immune response of chickens to UV-treated sporulated oocysts as a means of protection against caecal coccidiosis caused by field strains of Eimeria tenella. Two groups of chicks were immunized using prepared UV-t... Read More about Investigation into the potential of using UV-treated sporulated oocysts of Eimeria tenella as a local solution to immunization of chickens against caecal coccidiosis.

Prevalence of Eimeria species, detected by ITS1-PCR, in broiler poultry farms located in seven provinces of northeastern Algeria. (2022)
Journal Article
Djemai, S., Ayadi, O., Khelifi, D., Bellil, I., & Hide, G. (2022). Prevalence of Eimeria species, detected by ITS1-PCR, in broiler poultry farms located in seven provinces of northeastern Algeria. Tropical Animal Health and Production, 54(5), 250. https://doi.org/10.1007/s11250-022-03252-1

Coccidiosis is an important global chickens' disease which can cause serious economic losses in the poultry industry worldwide. Little is known about the extent of infection or diversity, of the causative agent Eimeria spp., in Algeria. A priority, t... Read More about Prevalence of Eimeria species, detected by ITS1-PCR, in broiler poultry farms located in seven provinces of northeastern Algeria..

Transplantation of Gut Microbiota From High-Fat-Diet-Tolerant Cynomolgus Monkeys Alleviates Hyperlipidemia and Hepatic Steatosis in Rats. (2022)
Journal Article
Gao, J., Rao, J., Wei, Z., Xia, S., Huang, L., Tang, M., …Chen, J. (2022). Transplantation of Gut Microbiota From High-Fat-Diet-Tolerant Cynomolgus Monkeys Alleviates Hyperlipidemia and Hepatic Steatosis in Rats. Frontiers in Microbiology, 13, 876043. https://doi.org/10.3389/fmicb.2022.876043

Emerging evidence has been reported to support the involvement of the gut microbiota in the host's blood lipid and hyperlipidemia (HLP). However, there remains unexplained variation in the host's blood lipid phenotype. Herein a nonhuman primate HLP m... Read More about Transplantation of Gut Microbiota From High-Fat-Diet-Tolerant Cynomolgus Monkeys Alleviates Hyperlipidemia and Hepatic Steatosis in Rats..

Vacuolar ATPase depletion contributes to dysregulation of endocytosis in bloodstream forms of Trypanosoma brucei (2020)
Journal Article
Xu, Z., Li, F., Hide, G., Lun, Z., & Lai, D. (2020). Vacuolar ATPase depletion contributes to dysregulation of endocytosis in bloodstream forms of Trypanosoma brucei. Parasites and Vectors, 13(1), 214. https://doi.org/10.1186/s13071-020-04068-4

BACKGROUND Vacuolar H-ATPase (V-ATPase) is a highly conserved protein complex which hydrolyzes ATP and pumps protons to acidify vacuolar vesicles. Beyond its role in pH maintenance, the involvement of V-ATPase in endocytosis is well documented in... Read More about Vacuolar ATPase depletion contributes to dysregulation of endocytosis in bloodstream forms of Trypanosoma brucei.

MAT Seroprevalence infers low rates of Toxoplasma gondii in domestic pigs from Yucatan, Mexico (2019)
Journal Article
Cubas-Atienzar, A., Hide, G., & Smith, J. (2019). MAT Seroprevalence infers low rates of Toxoplasma gondii in domestic pigs from Yucatan, Mexico. Journal of Parasitology, 105(5), 738-747. https://doi.org/10.1645/18-188

Toxoplasma gondii is a zoonotic parasite of worldwide distribution. The consumption of infected pork meat has been suggested to be an important source for human infection in the tropical area of Yucatan, Mexico. We performed a cross-sectional study o... Read More about MAT Seroprevalence infers low rates of Toxoplasma gondii in domestic pigs from Yucatan, Mexico.

High frequency of infection of lung cancer patients with the parasite Toxoplasma gondii (2019)
Journal Article
Bajnok, J., Tarabulsi, M., Carlin, H., Bown, K., Southworth, T., Dungwa, J., …Hide, G. (2019). High frequency of infection of lung cancer patients with the parasite Toxoplasma gondii. ERJ Open Research, 5(2), 1-10. https://doi.org/10.1183/23120541.00143-2018

Toxoplasma gondii is an intracellular protozoan parasite that can cause a wide range of clinical conditions, including miscarriage and pneumonia. The global prevalence is 30% in humans but varies locally (e.g. UK is typically 10%). The association be... Read More about High frequency of infection of lung cancer patients with the parasite Toxoplasma gondii.

The association between Toxoplasma gondii infection and postpartum blues (2019)
Journal Article
Gao, J., He, Z., Xie, Y., Hide, G., Lai, D., & Lun, Z. (2019). The association between Toxoplasma gondii infection and postpartum blues. Journal of Affective Disorders, 250, 404-409. https://doi.org/10.1016/j.jad.2019.03.013

Introduction and Aim: Toxoplasma gondii is an intracellular protozoan parasite infecting approximately 30% of the global human population. It has often been suggested that chronic infection with T. gondii is related to personality changes and vario... Read More about The association between Toxoplasma gondii infection and postpartum blues.

Genotyping of Toxoplasma gondii from pigs in Yucatan, Mexico (2018)
Journal Article
Cubas-Atienzar, A., Hide, G., Jiménez-Coello, M., Ortega-Pacheco, A., & Smith, J. (2018). Genotyping of Toxoplasma gondii from pigs in Yucatan, Mexico. Veterinary Parasitology: Regional Studies and Reports, 14, 191-199. https://doi.org/10.1016/j.vprsr.2018.10.009

Toxoplasmosis is a zoonotic disease of worldwide distribution. The parasite exhibits strong geographical patterns of strain variation with contrasting high levels of diversity across South America and restricted variation across North America. Litt... Read More about Genotyping of Toxoplasma gondii from pigs in Yucatan, Mexico.

Investigation into the genetic diversity in toll-like receptors 2 and 4 in the European badger Meles meles (2018)
Journal Article
Whiteoak, A., Ideozu, J., Alkathiry, H., Tomlinson, A., Delahay, R., Cowen, S., …Hide, G. (2018). Investigation into the genetic diversity in toll-like receptors 2 and 4 in the European badger Meles meles. Research in Veterinary Science, 119, 228-231. https://doi.org/10.1016/j.rvsc.2018.06.020

The Toll-like receptor (TLR) genes are a conserved family of genes central to the innate immune response to pathogen infection. They encode receptor proteins, recognise pathogen associated molecular patterns (PAMPs) and trigger initial immune respons... Read More about Investigation into the genetic diversity in toll-like receptors 2 and 4 in the European badger Meles meles.

Skin swabs with FTA® cards as a dry storage source for amphibian DNA (2018)
Journal Article
Ward, A., Hide, G., & Jehle, R. (2019). Skin swabs with FTA® cards as a dry storage source for amphibian DNA. Conservation Genetics Resources, 11, 309-311. https://doi.org/10.1007/s12686-018-1018-z

Amphibians are the most endangered group of vertebrates, and conservation measures increasingly rely on information drawn from genetic markers. The present study explores skin swabs with Whatman FTA® cards as a method to retrieve PCR-amplifiable amph... Read More about Skin swabs with FTA® cards as a dry storage source for amphibian DNA.

The effect of normal human serum on the mouse trypanosome Trypanosoma musculi in vitro and in vivo (2017)
Journal Article
Zhang, X., Hong, X., Li, S., Lai, D., Hide, G., Lun, Z., & Wen, Y. (2018). The effect of normal human serum on the mouse trypanosome Trypanosoma musculi in vitro and in vivo. Experimental Parasitology, 184, 115-120. https://doi.org/10.1016/j.exppara.2017.12.005

Trypanosoma musculi, a common blood flagellate found in mice, is similar in morphology and life cycle to the rat trypanosome T. lewisi. Both species belong to the subgenus Herpetosoma, and as T. lewisi has recently been shown to be a zoonotic pathoge... Read More about The effect of normal human serum on the mouse trypanosome Trypanosoma musculi in vitro and in vivo.

Nitric oxide blocks the development of the human parasite Schistosoma japonicum (2017)
Journal Article
Shen, J., Lai, D., Wilson, R., Chen, Y., Wang, L., Yu, Z., …Lun, Z. (2017). Nitric oxide blocks the development of the human parasite Schistosoma japonicum. Proceedings of the National Academy of Sciences of the United States of America, 114(38), 10214-10219. https://doi.org/10.1073/pnas.1708578114

Human schistosomiasis, caused by Schistosoma species, is a major public health problem affecting more than 700 million people in 78 countries, with over 40 mammalian host reservoir species complicating the transmission ecosystem. The primary cause of... Read More about Nitric oxide blocks the development of the human parasite Schistosoma japonicum.

Genetic analyses of Chinese isolates of Toxoplasma gondii reveal a new genotype with high virulence to murine hosts (2017)
Journal Article
Gao, J., Xie, Y., Xu, Z., Chen, H., Hide, G., Yang, T., …Lun, Z. (2017). Genetic analyses of Chinese isolates of Toxoplasma gondii reveal a new genotype with high virulence to murine hosts. Veterinary Parasitology, 241, 52-60. https://doi.org/10.1016/j.vetpar.2017.05.007

A great deal of evidence demonstrates that a strongly clonal population structure of Toxoplasma gondii strains exists in humans and animals in North America and Europe, while the strains from South America are genetically separate and more diverse. P... Read More about Genetic analyses of Chinese isolates of Toxoplasma gondii reveal a new genotype with high virulence to murine hosts.

Recombinant α-actinin subunit antigens of Trichomonas vaginalis as potential vaccine candidates in protecting against trichomoniasis (2017)
Journal Article
Xie, Y., Gao, J., Wu, Y., Tang, P., Hide, G., Lai, D., & Lun, Z. (2017). Recombinant α-actinin subunit antigens of Trichomonas vaginalis as potential vaccine candidates in protecting against trichomoniasis. Parasites and Vectors, 10(1), 83. https://doi.org/10.1186/s13071-017-2009-8

BACKGROUND: Human trichomoniasis caused by Trichomonas vaginalis is one of the most common sexually transmitted diseases with more than 200 million cases worldwide. It has caused a series of health problems to patients. For prevention and control of... Read More about Recombinant α-actinin subunit antigens of Trichomonas vaginalis as potential vaccine candidates in protecting against trichomoniasis.

Guanylate-binding Protein 1 (GBP1) contributes to the immunity of human mesenchymal stromal cells against toxoplasma gondii (2017)
Journal Article
Qin, A., Lai, D., Liu, Q., Huang, W., Wu, Y., Chen, X., …Xiang, A. (2017). Guanylate-binding Protein 1 (GBP1) contributes to the immunity of human mesenchymal stromal cells against toxoplasma gondii. Proceedings of the National Academy of Sciences, 114(6), 1365-1370. https://doi.org/10.1073/pnas.1619665114

Mesenchymal stromal cells (MSCs) have recently been shown to play important roles in mammalian host defenses against intracellular pathogens, but the molecular mechanism still needs to be clarified. We confirmed that human MSCs (hMSCs) pre-stimulated... Read More about Guanylate-binding Protein 1 (GBP1) contributes to the immunity of human mesenchymal stromal cells against toxoplasma gondii.