Outputs (31)

Pir2/Rnf144b is a potential endometrial cancer biomarker that promotes cell proliferation (2018)
Journal Article
Eldakhakhny, S., Zhou, Q., Conforti, F., Crosbie, E., Melino, G., & Sayan, B. (2018). Pir2/Rnf144b is a potential endometrial cancer biomarker that promotes cell proliferation. Cell Death and Disease, 9, https://doi.org/10.1038/s41419-018-0521-1

Endometrial cancer is one of the most common gynaecological cancers in developed countries. Its incidence has increased 20% over the last decade and the death rate has increased >100% over the past two decades. Current models for prediction of progno... Read More about Pir2/Rnf144b is a potential endometrial cancer biomarker that promotes cell proliferation.

Human papillomavirus E7 induces p63 expression to modulate DNA damage response (2018)
Journal Article
Eldakhakhny, S., Zhou, Q., Crosbie, E., & Sayan, B. (2018). Human papillomavirus E7 induces p63 expression to modulate DNA damage response. Cell Death and Disease, 9, https://doi.org/10.1038/s41419-017-0149-6

Cervical cancer is the third most common malignancy diagnosed in women worldwide. The major aetiological factor underlying the malignant transformation of cervical cells is the persistent infection with high-risk human papillomaviruses (HR-HPV), with... Read More about Human papillomavirus E7 induces p63 expression to modulate DNA damage response.

Urocortin suppresses endometrial cancer cell migration via CRFR2 and its system components are differentially modulated by estrogen (2017)
Journal Article
Owens, G., Lawrence, K., Jackson, T., Crosbie, E., Sayan, B., Kitchener, H., & Townsend, P. (2017). Urocortin suppresses endometrial cancer cell migration via CRFR2 and its system components are differentially modulated by estrogen. Cancer Medicine, 6(2), 408-415. https://doi.org/10.1002/cam4.967

Urocortin (UCN1) peptide shares structural and functional homology with corticotropin‐releasing factor (CRF). UCN1 is significantly reduced in endometrial adenocarcinoma compared to healthy controls. However, there are no data which evaluate the effe... Read More about Urocortin suppresses endometrial cancer cell migration via CRFR2 and its system components are differentially modulated by estrogen.

Urocortin - from Parkinson's disease to the skeleton (2014)
Journal Article
Lawrence, K., Jackson, T., Jamieson, D., Stevens, A., Owens, G., Sayan, B., …Townsend, P. (2014). Urocortin - from Parkinson's disease to the skeleton. International Journal of Biochemistry and Cell Biology, 60, 130-138. https://doi.org/10.1016/j.biocel.2014.12.005

Urocortin (Ucn 1), a 40 amino acid long peptide related to corticotropin releasing factor (CRF) was discovered 19 years ago, based on its sequence homology to the parent molecule. Its existence was inferred in the CNS because of anatomical and pharma... Read More about Urocortin - from Parkinson's disease to the skeleton.

p73 regulates serine biosynthesis in cancer (2013)
Journal Article
Amelio, I., Markert, E., Rufini, A., Antonov, A., Sayan, B., Tucci, P., …Melino, G. (2013). p73 regulates serine biosynthesis in cancer. Oncogene, 33, https://doi.org/10.1038/onc.2013.456

Activation of serine biosynthesis supports growth and proliferation of cancer cells. Human cancers often exhibit overexpression of phosphoglycerate dehydrogenase (PHGDH), the metabolic enzyme that catalyses the reaction that diverts serine biosynthes... Read More about p73 regulates serine biosynthesis in cancer.

Regulation of myocardial interleukin-6 expression by p53 and STAT1 (2013)
Journal Article
Carroll, C., Sayan, B., Bailey, S., & McCormick, J. (2013). Regulation of myocardial interleukin-6 expression by p53 and STAT1. Journal of Interferon and Cytokine Research, 33(9), https://doi.org/10.1089/jir.2012.0165

Cardiovascular diseases are a major cause of morbidity and mortality worldwide. The interferon inducible transcriptional activator signal transducer and activator of transcription-1 (STAT1) and p53 are two critical transcriptional factors that have p... Read More about Regulation of myocardial interleukin-6 expression by p53 and STAT1.

Pharmacoproteomic study of the natural product Ebenfuran III in DU-145 prostate cancer cells: The quantitative and temporal interrogation of chemically induced cell death at the protein level (2013)
Journal Article
Roumeltios, T., Halabalaki, M., Alexi, X., Ankrett, D., Giannopoulou, E., Sayan, B., & Skaltsounis, A. (2013). Pharmacoproteomic study of the natural product Ebenfuran III in DU-145 prostate cancer cells: The quantitative and temporal interrogation of chemically induced cell death at the protein level. Journal of Proteome Research, 12(4), 1591-1603. https://doi.org/10.1021/pr300968q

A naturally occurring benzofuran derivative, Ebenfuran III (Eb III), was investigated for its antiproliferative effects using the DU-145 prostate cell line. Eb III was isolated from Onobrychis ebenoides of the Leguminosae family, a plant endemic in C... Read More about Pharmacoproteomic study of the natural product Ebenfuran III in DU-145 prostate cancer cells: The quantitative and temporal interrogation of chemically induced cell death at the protein level.

PIR2/Rnf144B regulates epithelial homeostasis by mediating degradation of p21 WAF1 and p63 (2012)
Journal Article
Conforti, F., Yang, A., Piro, M., Mellone, M., Terrinoni, A., Candi, E., …Sayan, B. (2012). PIR2/Rnf144B regulates epithelial homeostasis by mediating degradation of p21 WAF1 and p63. Oncogene, 32, https://doi.org/10.1038/onc.2012.497

ΔNp63 is a transcription factor that is critical for the development of stratified epithelia and is overexpressed or amplified in >80% of squamous cell carcinomas (SCCs). We identified the RING finger E3 ubiquitin ligase PIR2/Rnf144b as a direct tran... Read More about PIR2/Rnf144B regulates epithelial homeostasis by mediating degradation of p21 WAF1 and p63.

Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer (2012)
Journal Article
Tucci, P., Agostini, M., Grespi, F., Merkert, E., Terrinoni, A., Vousden, K., …Sayan, B. (2012). Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer. Proceedings of the National Academy of Sciences, 109(38), https://doi.org/10.1073/pnas.1110977109

p63 inhibits metastasis. Here, we show that p63 (both TAp63 and ΔNp63 isoforms) regulates expression of miR-205 in prostate cancer (PCa) cells, and miR-205 is essential for the inhibitory effects of p63 on markers of epithelial–mesenchymal transition... Read More about Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer.

Apoptin induces apoptosis by changing the equilibrium between the stability of TAp73 and DNp73 isoforms through ubiquitin ligase PIR2 (2012)
Journal Article
Taebunpakul, P., Sayan, B., Flinterman, M., Klanrit, P., Gaken, J., Odell, E., …Tavassoli, M. (2012). Apoptin induces apoptosis by changing the equilibrium between the stability of TAp73 and DNp73 isoforms through ubiquitin ligase PIR2. Apoptosis, 17, https://doi.org/10.1007/s10495-012-0720-7

Apoptin, a protein derived from the chicken anaemia virus, induces cell death in various cancer cells but shows little or no cytotoxicity in normal cells. The mechanism of apoptin-induced cell death is currently unknown but it appears to induce apopt... Read More about Apoptin induces apoptosis by changing the equilibrium between the stability of TAp73 and DNp73 isoforms through ubiquitin ligase PIR2.