Skip to main content

Research Repository

Advanced Search

Outputs (131)

The occurrence of malignancy in Trypanosoma brucei brucei by rapid passage in mice (2022)
Journal Article
Cai, X., Li, S., Zhang, P., Li, Z., Hide, G., Lai, D., & Lun, Z. (2022). The occurrence of malignancy in Trypanosoma brucei brucei by rapid passage in mice. Frontiers in Microbiology, 12, 806626. https://doi.org/10.3389/fmicb.2021.806626

Pleomorphic Trypanosoma brucei are best known for their tightly controlled cell growth and developmental program, which ensures their transmissibility and host fitness between the mammalian host and insect vector. However, after long-term adaptation... Read More about The occurrence of malignancy in Trypanosoma brucei brucei by rapid passage in mice.

Species identification and phylogenetic analysis of Leishmania isolated from patients, vectors and hares in the Xinjiang Autonomous Region, The People's Republic of China (2021)
Journal Article
Chen, Y., Liao, L., Wu, N., Gao, J., Zhang, P., Wen, Y., …Lun, Z. (2021). Species identification and phylogenetic analysis of Leishmania isolated from patients, vectors and hares in the Xinjiang Autonomous Region, The People's Republic of China. PLoS Neglected Tropical Diseases, 15(12), e0010055. https://doi.org/10.1371/journal.pntd.0010055

Visceral leishmaniasis (VL) has been declared as one of the six major tropical diseases by the World Health Organization. This disease has been successfully controlled in China, except for some areas in the western region, such as the Xinjiang Autono... Read More about Species identification and phylogenetic analysis of Leishmania isolated from patients, vectors and hares in the Xinjiang Autonomous Region, The People's Republic of China.

A new species of mammalian trypanosome, Trypanosoma (Megatrypanum) bubalisi sp. nov., found in the freshwater leech Hirudinaria manillensis (2021)
Journal Article
Su, B., Wang, J., Yang, T., Hide, G., Lai, D., & Lun, Z. (2021). A new species of mammalian trypanosome, Trypanosoma (Megatrypanum) bubalisi sp. nov., found in the freshwater leech Hirudinaria manillensis. International Journal for Parasitology, https://doi.org/10.1016/j.ijpara.2021.10.009

Leeches have long been considered potential vectors for the aquatic lineage of trypanosomes, while bloodsucking insects are generally considered as the vectors for the terrestrial lineage of trypanosomes. The freshwater leech, Hirudinaria manillensis... Read More about A new species of mammalian trypanosome, Trypanosoma (Megatrypanum) bubalisi sp. nov., found in the freshwater leech Hirudinaria manillensis.

Innate resistance to Leishmania amazonensis Infection in rat is dependent on NOS2 (2021)
Journal Article
Chen, Y., Yu, S., Wu, C., Wu, N., Shen, J., Shen, J., …Lun, Z. (2021). Innate resistance to Leishmania amazonensis Infection in rat is dependent on NOS2. Frontiers in Microbiology, 12, 733286. https://doi.org/10.3389/fmicb.2021.733286

Leishmania infection causes diverse clinical manifestations in humans. The disease outcome is complicated by the combination of many host and parasite factors. Inbred mouse strains vary in resistance to Leishmania major but are highly susceptible to... Read More about Innate resistance to Leishmania amazonensis Infection in rat is dependent on NOS2.

High resistance to Toxoplasma gondii infection in inducible nitric oxide synthase (iNOS) knockout rats (2021)
Journal Article
Wang, Z., Yu, S., Gao, J., Zhang, P., Hide, G., Yamamoto, M., …Lun, Z. (2021). High resistance to Toxoplasma gondii infection in inducible nitric oxide synthase (iNOS) knockout rats. iScience, 24(11), 103280. https://doi.org/10.1016/j.isci.2021.103280

Nitric oxide (NO) is an important immune molecule which acts against extra- and intracellular pathogens in most hosts. However, after knockout of inducible nitric oxide synthase (iNOS-/-) in Sprague Dawley (SD) rats, these iNOS-/- rats were found to... Read More about High resistance to Toxoplasma gondii infection in inducible nitric oxide synthase (iNOS) knockout rats.

Identification of an orally active carbazole aminoalcohol derivative with broad-spectrum anti-animal trypanosomiasis activity (2021)
Journal Article
Cai, X., Wang, W., Lai, D., Zhang, X., Yao, J., Yu, Y., …Lun, Z. (2021). Identification of an orally active carbazole aminoalcohol derivative with broad-spectrum anti-animal trypanosomiasis activity. Acta tropica, 219, 105919. https://doi.org/10.1016/j.actatropica.2021.105919

Animal trypanosomiasis, caused by the members of subgenus Trypanozoon (Trypanosoma brucei brucei, T. evansi and T. equiperdum), has reduced animal productivity leading to significant negative economic impacts in endemic regions. Due to limited drug d... Read More about Identification of an orally active carbazole aminoalcohol derivative with broad-spectrum anti-animal trypanosomiasis activity.

Infection with Trypanosoma lewisi or Trypanosoma musculi may promote the spread of Toxoplasma gondii (2021)
Journal Article
Gao, J., Yi, S., Geng, G., Xu, Z., Hide, G., Lun, Z., & Lai, D. (2021). Infection with Trypanosoma lewisi or Trypanosoma musculi may promote the spread of Toxoplasma gondii. Parasitology, 148(6), 703-711. https://doi.org/10.1017/S0031182021000196

Toxoplasma gondii can infect almost all warm-blooded vertebrates with pathogensis being largely influenced by the host immune status. As important epidemiological hosts, rodents are globally distributed and are also commonly found infected with ha... Read More about Infection with Trypanosoma lewisi or Trypanosoma musculi may promote the spread of Toxoplasma gondii.

Long-term trends in helminth infections of wood mice (Apodemus sylvaticus) from the vicinity of Malham Tarn in North Yorkshire, England (2020)
Journal Article
Behnke, J., Rogan, M., Craig, P., Jackson, J., & Hide, G. (2021). Long-term trends in helminth infections of wood mice (Apodemus sylvaticus) from the vicinity of Malham Tarn in North Yorkshire, England. Parasitology, 184(4), 451-463. https://doi.org/10.1017/S0031182020002243

Helminth infections in wood mice (n=483), trapped over a period of 26 years in the woods surrounding Malham Tarn in N. Yorkshire, were analysed. Although ten species of helminths were identified, the overall mean species richness was 1.01 species/m... Read More about Long-term trends in helminth infections of wood mice (Apodemus sylvaticus) from the vicinity of Malham Tarn in North Yorkshire, England.

Novel organization of mitochondrial minicircles and guide RNAs in the zoonotic pathogen Trypanosoma lewisi (2020)
Journal Article
Li, S., Zhang, X., Lukeš, J., Li, B., Wang, J., Qu, L., …Lun, Z. (2020). Novel organization of mitochondrial minicircles and guide RNAs in the zoonotic pathogen Trypanosoma lewisi. Nucleic Acids Research, 48(17), 9747-9761. https://doi.org/10.1093/nar/gkaa700

Abstract Kinetoplastid flagellates are known for several unusual features, one of which is their complex mitochondrial genome, known as kinetoplast (k) DNA, composed of mutually catenated maxi- and minicircles. Trypanosoma lewisi is a member of the S... Read More about Novel organization of mitochondrial minicircles and guide RNAs in the zoonotic pathogen Trypanosoma lewisi.