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Outputs (16)

A product of skin microbiota improves hallmarks of wound healing in diabetes mellitus: an in vitro investigation (2025)
Thesis

Diabetes mellitus is a critical global health disease characterised by persistent hyperglycaemia, which leads to various complications. Poor wound healing and diabetic foot ulcers are the two main complications of this disease. Lysates and cellfree s... Read More about A product of skin microbiota improves hallmarks of wound healing in diabetes mellitus: an in vitro investigation.

Assessment of an ex vivo porcine lung model to investigate host-microbe interactions in cases of ventilator associated pneumonia (2021)
Thesis

VAP is described as a pneumonic lung infection afflicting those that have been mechanically ventilated typically with an endotracheal tube. Unfortunately, there is no singular diagnostic test for VAP (Grossman & Fein, 2000) or ‘gold standard’ for the... Read More about Assessment of an ex vivo porcine lung model to investigate host-microbe interactions in cases of ventilator associated pneumonia.

Proinflammatory cytokines as mediators of phenotypic change in bacteria implicated in ventilator-associated pneumonia (2021)
Thesis
Tompsett, A. Proinflammatory cytokines as mediators of phenotypic change in bacteria implicated in ventilator-associated pneumonia. (Thesis). University of Salford

Ventilator-associated pneumonia (VAP) is a common hospital-acquired infection in intensive care. VAP is associated with increased hospital stay, healthcare costs, and high mortality. VAP is difficult to diagnose and manage appropriately, leading to w... Read More about Proinflammatory cytokines as mediators of phenotypic change in bacteria implicated in ventilator-associated pneumonia.

A myristoyl amide derivative of doxycycline potently targets cancer stem cells (CSCs) and prevents metastasis, without retaining antibiotic activity (2020)
Journal Article

Here, we describe the chemical synthesis and biological activity of a new Doxycycline derivative, designed specifically to more effectively target cancer stem cells (CSCs). In this analogue, a myristic acid (14 carbon) moiety is covalently attached t... Read More about A myristoyl amide derivative of doxycycline potently targets cancer stem cells (CSCs) and prevents metastasis, without retaining antibiotic activity.

The efficacy and adverse events of delafloxacin for treating acute bacterial skin and skin structure infections : a systematic review and meta-analysis (2020)
Journal Article
Qasim, S., Tanvir, S., Latimer, J., Qamar, Z., & Niazi, F. (2020). The efficacy and adverse events of delafloxacin for treating acute bacterial skin and skin structure infections : a systematic review and meta-analysis. Journal of Pharmacy and Bioallied Sciences, 12(5), 538-545. https://doi.org/10.4103/jpbs.JPBS_154_20

Background: Acute bacterial skin and skin structure infections (ABSSSI) cause significant morbidity and mortality in hospitalized patients and outpatients as well. Newer fluoroquinolones such as delafloxacin might be a useful medication for treating... Read More about The efficacy and adverse events of delafloxacin for treating acute bacterial skin and skin structure infections : a systematic review and meta-analysis.

Simultaneous assessment of acidogenesis-mitigation and specific bacterial growth-inhibition by dentifrices (2016)
Journal Article
Yilmaz, Ö., Forbes, S., Latimer, J., Sreenivasan, P., & McBain, A. (2016). Simultaneous assessment of acidogenesis-mitigation and specific bacterial growth-inhibition by dentifrices. PLoS ONE, 11(2), e0149390. https://doi.org/10.1371/journal.pone.0149390

Dentifrices can augment oral hygiene by inactivating bacteria and at sub-lethal concentrations may affect bacterial metabolism, potentially inhibiting acidogenesis, the main cause of caries. Reported herein is the development of a rapid method to sim... Read More about Simultaneous assessment of acidogenesis-mitigation and specific bacterial growth-inhibition by dentifrices.

Antibacterial efficacy of a cetylpyridinium chloride-based mouthrinse against Fusobacterium nucleatum and in vitro plaques (2015)
Journal Article
Latimer, J., Munday, J., Buzza, K., Sreenivasan, P., & McBain, A. (2015). Antibacterial efficacy of a cetylpyridinium chloride-based mouthrinse against Fusobacterium nucleatum and in vitro plaques. American journal of dentistry, 28 Spe, 9A-13A

PURPOSE

To assess the antimicrobial effects of a fluoride-free and alcohol-free mouthrinse containing 0.075% CPC (test rinse, TR) compared with an otherwise-identical CPC-free control rinse (CR).

METHODS

Activity against laboratory cultures... Read More about Antibacterial efficacy of a cetylpyridinium chloride-based mouthrinse against Fusobacterium nucleatum and in vitro plaques.

Antibacterial and anti-biofilm activity of mouthrinses containing cetylpyridinium chloride and sodium fluoride (2015)
Journal Article
Latimer, J., Munday, J., Buzza, K., Forbes, S., Sreenivasan, P., & McBain, A. (2015). Antibacterial and anti-biofilm activity of mouthrinses containing cetylpyridinium chloride and sodium fluoride. BMC Microbiology, 15(169), https://doi.org/10.1186/s12866-015-0501-x

Background

Cetylpyridinium chloride (CPC) and sodium fluoride augment oral hygiene by inactivating bacteria and inhibiting enamel demineralisation, respectively. However, there are few reports in the literature documenting the antibacterial effic... Read More about Antibacterial and anti-biofilm activity of mouthrinses containing cetylpyridinium chloride and sodium fluoride.