School of Science, Engineering & Environment

Plasma interleukin responses as predictors of outcome stratification in patients after major trauma: a prospective observational two centre study (2023)
Journal Article
Jones, M. A., Hanison, J., Apreutesei, R., Allarakia, B., Namvar, S., Ramaswamy, D. S., …Nirmalan, N. (2023). Plasma interleukin responses as predictors of outcome stratification in patients after major trauma: a prospective observational two centre study. Frontiers in Immunology, 14, 1276171. https://doi.org/10.3389/fimmu.2023.1276171

Background and objectives: There is a need to develop objective risk stratification tools to define efficient care pathways for trauma patients. Biomarker-based point of care testing may strengthen existing clinical tools currently available for this... Read More about Plasma interleukin responses as predictors of outcome stratification in patients after major trauma: a prospective observational two centre study.

High frequency of infection of lung cancer patients with the parasite Toxoplasma gondii (2019)
Journal Article
Bajnok, J., Tarabulsi, M., Carlin, H., Bown, K., Southworth, T., Dungwa, J., …Hide, G. (2019). High frequency of infection of lung cancer patients with the parasite Toxoplasma gondii. ERJ Open Research, 5(2), 1-10. https://doi.org/10.1183/23120541.00143-2018

Toxoplasma gondii is an intracellular protozoan parasite that can cause a wide range of clinical conditions, including miscarriage and pneumonia. The global prevalence is 30% in humans but varies locally (e.g. UK is typically 10%). The association be... Read More about High frequency of infection of lung cancer patients with the parasite Toxoplasma gondii.

Corticosteroid treatment is associated with increased filamentous fungal burden in allergic fungal disease (2017)
Journal Article
allergic fungal disease. Journal of Allergy and Clinical Immunology, 142(2), 407-414. https://doi.org/10.1016/j.jaci.2017.09.039

Background Allergic diseases caused by fungi are common. The best understood conditions are allergic bronchopulmonaryaspergillosis (ABPA) and severe asthma with fungal sensitisation (SAFS). Our knowledge of the fungal microbiome (mycobiome) is li... Read More about Corticosteroid treatment is associated with increased filamentous fungal burden in allergic fungal disease.

The effects of corticosteroids on cytokine production from asthma lung lymphocytes (2014)
Journal Article
Kaur, M., Reynolds, S., Smyth, L., Simpson, K., Hall, S., & Singh, D. (2014). The effects of corticosteroids on cytokine production from asthma lung lymphocytes. International Immunopharmacology, 23(2), 581-4. https://doi.org/10.1016/j.intimp.2014.10.008

BACKGROUND Lymphocytes play a central role in the pathophysiology of asthma. Corticosteroids have a limited effect in severe asthma and we hypothesise that lymphocytes play a central role in corticosteroid insensitivity. We investigated the effect... Read More about The effects of corticosteroids on cytokine production from asthma lung lymphocytes.

Increased airway T regulatory cells in asthmatic subjects (2010)
Journal Article
Smyth, L., Eustace, A., Kolsum, U., Blaikely, J., & Singh, D. (2010). Increased airway T regulatory cells in asthmatic subjects. Chest, 138(4), 905-912. https://doi.org/10.1378/chest.09-3079

Background: T regulatory cells (Tregs) may play a role in the suppression of effector lymphocyte activity in asthma. We hypothesized that Treg numbers would be increased in patients with more severe asthma. We also investigated the regulatory functio... Read More about Increased airway T regulatory cells in asthmatic subjects.

Role of regulatory T-cells in COPD (2010)
Journal Article
Plumb, J., Smyth, L., & Singh, D. (2010). Role of regulatory T-cells in COPD

Chronic Obstructive Pulmonary Disease (COPD) is characterized by progressive and irreversible airflow limitation, caused in most cases by cigarette smoking. Increased CD8 cell numbers are associated with disease progression, and the presence of terti... Read More about Role of regulatory T-cells in COPD.

Reply to comment on chest-10-1440 : Increased airway T regulatory cells in asthmatic subjects (2010)
Journal Article
Smyth, L., Eustace, A., Kolsum, U., Blaikely, J., & Singh, D. (2010). Reply to comment on chest-10-1440 : Increased airway T regulatory cells in asthmatic subjects. Chest,

Identification of cells expressing Interleukin-17A and F in the lungs of COPD patients (2010)
Journal Article
Eustace, A., Smyth, L., Mitchell, L., Williamson, K., Plumb, J., & Singh, D. (2010). Identification of cells expressing Interleukin-17A and F in the lungs of COPD patients. Chest, https://doi.org/10.1378/chest.10-0779

Background: Lymphocytes secrete IL-17A and IL-17F which enhance innate immune responses. IL-17 expression has not been studied in COPD small airways. The aim was to quantify IL-17A and IL-17F expression in the peripheral lung tissue of COPD patients... Read More about Identification of cells expressing Interleukin-17A and F in the lungs of COPD patients.

A randomized, placebo-controlled study of the effects of the p38 MAPK inhibitor SB-681323 on blood biomarkers of inflammation in COPD patients (2010)
Journal Article
Singh, D., Smyth, L., Borrill, Z., Sweeney, L., & Tal-Singer, R. (2010). A randomized, placebo-controlled study of the effects of the p38 MAPK inhibitor SB-681323 on blood biomarkers of inflammation in COPD patients. Journal of Clinical Pharmacology, 50(1), 94-100. https://doi.org/10.1177/0091270009347873

The p38 mitogen-activated protein kinase (MAPK) signaling upregulates inflammation and is known to be increased in chronic obstructive pulmonary disease (COPD). The authors assessed the pharmacology of the novel p38 MAPK inhibitor SB-681323 using blo... Read More about A randomized, placebo-controlled study of the effects of the p38 MAPK inhibitor SB-681323 on blood biomarkers of inflammation in COPD patients.

Outputs (22)