Detecting the shape of anisotropic gold nanoparticles in dispersion with single particle extinction and scattering

Marco A, C., P; Krpetic, Z; Tiziano, S; Qi, C; Marco, M; João M., de A; Claudia, C; Luca, B; Valentina, C; Paolo, M; Kenneth A., D

Abstract

The shape and size of nanoparticles are important parameters affecting the biodistribution, bioactivity, and toxicity. The
high-throughput characterisation of nanoparticle shape in the dispersion is a fundamental prerequisite for realistic in vitro
and in vivo evaluation, however, with routinely available bench-top optical characterisation techniques, it remains a
challenging task. Herein, we demonstrate the efficacy of Single Particle Extinction and Scattering (SPES) technique for the
in situ detection of the shape of nanoparticles in dispersion, applied to a small library of anisotropic gold particles, with
potential developments of in-line detection. The use of SPES paves the way to the routine quantitative analysis of
nanoparticles dispersed in biologically relevant fluids, which is of importance for the nanosafety assessment and any in
vitro and in vivo administration of nanomaterials.

Citation

Marco A, C., P., Krpetic, Z., Tiziano, S., Qi, C., Marco, M., João M., D. A., …Kenneth A., D. (2017). Detecting the shape of anisotropic gold nanoparticles in dispersion with single particle extinction and scattering. Nanoscale, 8, https://doi.org/10.1039/C6NR08977A

• Journal Article Type: Article
• Acceptance Date: Jan 12, 2017
• Online Publication Date: Jan 19, 2017
• Publication Date: Jan 19, 2017
• Deposit Date: Jan 20, 2017
• Publicly Available Date: Jan 21, 2017
• Journal: Nanoscale
• Print ISSN: 2040-3364
• Electronic ISSN: 2040-3372
• Publisher: Royal Society of Chemistry
• Volume: 8
• DOI: https://doi.org/10.1039/C6NR08977A
• Publisher URL: http://dx.doi.org/10.1039/C6NR08977A
• Related Public URLs: http://pubs.rsc.org/en/Journals/JournalIssues/NR#!recentarticles&adv
• Additional Information: Funders : European Commission; Projects : EU FP7 'FutureNanoNeeds'; Grant Number: grant agreement number 604602; Grant Number: NMP.2013.1.3-3