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Detecting the shape of anisotropic gold nanoparticles in dispersion with single particle extinction and scattering

Marco A, C., P; Krpetic, Z; Tiziano, S; Qi, C; Marco, M; João M., de A; Claudia, C; Luca, B; Valentina, C; Paolo, M; Kenneth A., D

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Authors

P Marco A, C.

S Tiziano

C Qi

M Marco

de A João M.

C Claudia

B Luca

C Valentina

M Paolo

D Kenneth A.



Abstract

The shape and size of nanoparticles are important parameters affecting the biodistribution, bioactivity, and toxicity. The
high-throughput characterisation of nanoparticle shape in the dispersion is a fundamental prerequisite for realistic in vitro
and in vivo evaluation, however, with routinely available bench-top optical characterisation techniques, it remains a
challenging task. Herein, we demonstrate the efficacy of Single Particle Extinction and Scattering (SPES) technique for the
in situ detection of the shape of nanoparticles in dispersion, applied to a small library of anisotropic gold particles, with
potential developments of in-line detection. The use of SPES paves the way to the routine quantitative analysis of
nanoparticles dispersed in biologically relevant fluids, which is of importance for the nanosafety assessment and any in
vitro and in vivo administration of nanomaterials.

Citation

Marco A, C., P., Krpetic, Z., Tiziano, S., Qi, C., Marco, M., João M., D. A., …Kenneth A., D. (2017). Detecting the shape of anisotropic gold nanoparticles in dispersion with single particle extinction and scattering. Nanoscale, 8, https://doi.org/10.1039/C6NR08977A

Journal Article Type Article
Acceptance Date Jan 12, 2017
Online Publication Date Jan 19, 2017
Publication Date Jan 19, 2017
Deposit Date Jan 20, 2017
Publicly Available Date Jan 21, 2017
Journal Nanoscale
Print ISSN 2040-3364
Electronic ISSN 2040-3372
Publisher Royal Society of Chemistry
Volume 8
DOI https://doi.org/10.1039/C6NR08977A
Publisher URL http://dx.doi.org/10.1039/C6NR08977A
Related Public URLs http://pubs.rsc.org/en/Journals/JournalIssues/NR#!recentarticles&adv
Additional Information Funders : European Commission
Projects : EU FP7 'FutureNanoNeeds'
Grant Number: grant agreement number 604602
Grant Number: NMP.2013.1.3-3

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