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Directed assembly of DNA-functionalized gold nanoparticles using pyrrole–imidazole polyamides

Krpetic, Z; Singh, I; Su, W; Guerrini, L; Faulds, K; Burley, GA; Graham, D

Authors

I Singh

W Su

L Guerrini

K Faulds

GA Burley

D Graham



Abstract

Traditional methods for the construction of nanoparticle arrays and lattices exploit Watson–Crick base pairing of single-stranded DNA sequences as a proxy for self-assembly. Although this approach has been utilized in a variety of applications in nanoassembly, diagnostics, and biomedicine, the diversity of this recognition lexicon could be considerably increased by developing strategies that recognize the base-pairing landscape of double-stranded DNA (dsDNA) sequences. Herein we describe the first report of programmed gold nanoparticle (GNP) aggregation directed by the recognition of dsDNA sequences using pyrrole–imidazole polyamide–GNP (PA–GNP) conjugates. We demonstrate the reversibility and selectivity of this strategy for forming GNP aggregates in the presence of fully matched dsDNA sequences relative to dsDNA sequences containing one- and two-base-pair mismatches.

Citation

Krpetic, Z., Singh, I., Su, W., Guerrini, L., Faulds, K., Burley, G., & Graham, D. (2012). Directed assembly of DNA-functionalized gold nanoparticles using pyrrole–imidazole polyamides. Abstracts of papers / American Chemical Society, 134(20), 8356-8359. https://doi.org/10.1021/ja3014924

Journal Article Type Article
Online Publication Date May 7, 2012
Publication Date May 7, 2012
Deposit Date Oct 6, 2016
Journal Journal of the American Chemical Society
Print ISSN 0002-7863
Volume 134
Issue 20
Pages 8356-8359
DOI https://doi.org/10.1021/ja3014924
Publisher URL http://dx.doi.org/10.1021/ja3014924
Related Public URLs http://pubs.acs.org/doi/abs/10.1021/ja3014924
Additional Information Funders : Engineering and Physical Sciences Research Council (EPSRC);Royal Society
Projects : Advanced Research Fellowship;Postdoctoral fellowship;Wolfson Research Merit Award
Grant Number: EP/E055095/1
Grant Number: (EP/G048878/1
Grant Number: Wolfson Research Merit Award to Prof Duncan Graham