A practical radiosynthesis of a tritium-labelled fluoro combretastatin

Hadfield, JA; Hirst, N; Mcgown, A; Lawrence, NJ; Gaukroger, K

Abstract

Zybrestat (combretastatin A-4 disodium diphosphate) is currently in clinical trials as an antivascular anticancer agent. A similar fluorinated agent has shown promise as an antivascular agent and a radiolabelled version would enable further understanding of its biological activities. Herein is described the synthesis of a tritiated fluorinated analogue of Zybrestat.

Citation

Hadfield, J., Hirst, N., Mcgown, A., Lawrence, N., & Gaukroger, K. (2012). A practical radiosynthesis of a tritium-labelled fluoro combretastatin. Journal of Labelled Compounds and Radiopharmaceuticals, 55(8), 303-306. https://doi.org/10.1002/jlcr.2939

• Journal Article Type: Article
• Publication Date: Jan 1, 2012
• Deposit Date: May 31, 2012
• Journal: Journal of Labelled Compounds and Radiopharmaceuticals
• Print ISSN: 0362-4803
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 55
• Issue: 8
• Pages: 303-306
• DOI: https://doi.org/10.1002/jlcr.2939
• Publisher URL: http://dx.doi.org/10.1002/jlcr.2939
• Related Public URLs: http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-1344/issues