Dominik W. Schmid
Co-infections mask pathogen-specific associations with the gut microbiota in wild voles
Schmid, Dominik W.; Risely, Alice
Abstract
Research Highlight: Brila, I., Lavirinienko, A., Tukalenko, E., Kallio, E. R., Mappes, T. & Watts, P. C. (2022). Idiosyncratic effects of coinfection on the association between systemic pathogens and the gut microbiota of a wild rodent, the bank vole (Myodes glareolus). Journal of Animal Ecology, https://besjournals.onlinelibrary.wiley.com/doi/10.1111/1365-2656.13869. Interactions between pathogens and host-associated microbial communities can influence host fitness, disease progression and pathogen emergence. The vast majority of studies characterize interactions between single pathogens and bacterial commensals, yet co-infections with multiple pathogens are the norm in nature. In their paper on pathogen–microbiome interactions, Brila et al. (2022) examine how co-infections with four systemic pathogens associate with the gut microbiota in wild bank voles. Building on a series of tests, the authors show that excluding co-infection information from statistical models masks pathogen-specific patterns and confounds interpretations. This paper advances on previous studies by generating surveillance data on a phylogenetically diverse suite of vole pathogens to address the question as to whether pathogens exhibit unique or universal associations with gut commensals. They report that even bacterial pathogens with similar transmission ecology have divergent associations with gut microbes, and highlight that a mechanistic understanding of host–pathogen interactions is necessary for decoding the diverse consequences for gut microbial communities.
Citation
Schmid, D. W., & Risely, A. (2023). Co-infections mask pathogen-specific associations with the gut microbiota in wild voles. Journal of Animal Ecology, 92(4), 790-793. https://doi.org/10.1111/1365-2656.13906
Journal Article Type | Commentary |
---|---|
Acceptance Date | Feb 15, 2023 |
Publication Date | Apr 5, 2023 |
Deposit Date | Nov 2, 2023 |
Publicly Available Date | Apr 6, 2024 |
Journal | Journal of Animal Ecology |
Print ISSN | 0021-8790 |
Publisher | Wiley |
Peer Reviewed | Peer Reviewed |
Volume | 92 |
Issue | 4 |
Pages | 790-793 |
DOI | https://doi.org/10.1111/1365-2656.13906 |
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Copyright Statement
This is the peer reviewed version of the following article: [Schmid, D. W., & Risely, A. (2023). Co-infections mask pathogen-specific associations with the gut microbiota in wild voles. Journal of Animal Ecology, 92, 790–793], which has been published in final form at [https://doi.org/10.1111/1365-2656.13906]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
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