Treatment Effect Measures Under Nonproportional Hazards

Jackson, Dan; Sweeting, Michael; Baker, Rose

Abstract

‘Treatment effect measures under nonproportional hazards’ by Snapinn et al. (Pharmaceutical Statistics, 22, 181–193) recently proposed some novel estimates of treatment effect for time‐to‐event endpoints. In this note, we clarify three points related to the proposed estimators that help to elucidate their properties. We hope that their work, and this commentary, will motivate further discussion concerning treatment effect measures that do not require the proportional hazards assumption.

• Journal Article Type: Commentary
• Acceptance Date: Oct 2, 2024
• Online Publication Date: Oct 27, 2024
• Publication Date: 2025-03
• Deposit Date: Apr 16, 2025
• Journal: Pharmaceutical Statistics
• Print ISSN: 1539-1604
• Electronic ISSN: 1539-1612
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 24
• Issue: 2
• Article Number: e2449
• DOI: https://doi.org/10.1002/pst.2449