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All Outputs (82)

Prescribing for children (2018)
Journal Article

In this article in the series of ‘bite sized’ pharmacology, we will look at the pharmacological considerations when prescribing for children. This article will illustrate the common issues to consider when prescribing for the under 18 (or more often... Read More about Prescribing for children.

Drugs used in respiratory conditions (2017)
Journal Article
Robertson, D. (2017). Drugs used in respiratory conditions. Nurse Prescribing, 15(11), 563-566. https://doi.org/10.12968/npre.2017.15.11.563

In this article our ‘bite sized’ pharmacology series, we will look at the pharmacological actions of drugs used in respiratory conditions. This article will illustrate the common therapeutic interventions in asthma and chronic obstructive pulmonary d... Read More about Drugs used in respiratory conditions.

Side effects and adverse drug reactions (2017)
Journal Article
Robertson, D. (2017). Side effects and adverse drug reactions. Nurse Prescribing, 15(10), 512-514. https://doi.org/10.12968/npre.2017.15.10.512

This article will look at the pharmacological aspects surrounding side effects of drugs, adverse drug reactions and the key differences between the two. It will also touch on the concept of drug ‘allergy’ and its meaning from a pharmacological perspe... Read More about Side effects and adverse drug reactions.

Drug disposition, bioavailability and efficacy (2017)
Journal Article
Robertson, D. (2017). Drug disposition, bioavailability and efficacy. Nurse Prescribing, 15(8), 409-411. https://doi.org/10.12968/npre.2017.15.8.409

In this article, we will look at the concepts of drug disposition, bioavailability and efficacy. Drug distribution can be defined as getting a drug into its appropriate position in the body at an appropriate concentration. This is represented by phar... Read More about Drug disposition, bioavailability and efficacy.

Agonistic and antagonistic drug action (2017)
Journal Article
Robertson, D. (2017). Agonistic and antagonistic drug action. Nurse Prescribing, 15(7), 356-358. https://doi.org/10.12968/npre.2017.15.7.356

In this article in the series of ‘bite sized’ pharmacology, we will look at the concepts of agonism and antagonism with regards to drug action. These pharmacodynamic actions affect how a drug acts at its target site and the body's response to the dru... Read More about Agonistic and antagonistic drug action.

Drug action: The therapeutic effect (2017)
Journal Article
Robertson, D. (2017). Drug action: The therapeutic effect. Nurse Prescribing, 15(5), 253-255. https://doi.org/10.12968/npre.2017.15.5.253

In this article in the series of ‘bite sized’ pharmacology, we will look at the concept of drug action—the therapeutic effect of the medications we give. It is important that prescribers are aware of factors that can affect drug action and the time-t... Read More about Drug action: The therapeutic effect.

Uses, interactions and side effects of aspirin in older people (2013)
Journal Article
Robertson, D. (2013). Uses, interactions and side effects of aspirin in older people. Nursing and Residential Care, 15(5), 263-266. https://doi.org/10.12968/nrec.2013.15.5.263

Aspirin's longevity as a therapeutic medicine can be attributed to its effectiveness and multiplicity of uses. Deborah Robertson advises that this drug, despite its versatility, must be used with caution, particularly in the elderly population

Influence of 5,7-dihydroxytryptamine lesions of the rat fornix—fimbria and cingulum bundles on spontaneous activity in an aversive maze (2008)
Journal Article
Robertson, D., Beattie, J., Reid, I., & Balfour, D. (2008). Influence of 5,7-dihydroxytryptamine lesions of the rat fornix—fimbria and cingulum bundles on spontaneous activity in an aversive maze. Journal of Psychopharmacology, 22(3), 285-289. https://doi.org/10.1177/0269881107083841

Exposure to aversive environmental stimuli stimulates the serotonergic neurones that project to the forebrain and inhibit spontaneous activity when studied in a simple maze. This study explored the putative role of the principal 5-hydroxytryptamine (... Read More about Influence of 5,7-dihydroxytryptamine lesions of the rat fornix—fimbria and cingulum bundles on spontaneous activity in an aversive maze.

The effect of stress on the expression of the amyloid precursor protein in rat brain (2007)
Journal Article
Sayer, R., Robertson, D., J.K. Balfour, D., C. Breen, K., & A. Stewart, C. (2008). The effect of stress on the expression of the amyloid precursor protein in rat brain. Neuroscience Letters, 431(6), 197-200. https://doi.org/10.1016/j.neulet.2007.11.032

The abnormal processing of the amyloid precursor protein (APP) is a pivotal event in the development of the unique pathology that defines Alzheimer's disease (AD). Stress, and the associated increase in corticosteroids, appear to accelerate brain age... Read More about The effect of stress on the expression of the amyloid precursor protein in rat brain.

Behavioural and neurochemical responses evoked by repeated exposure to an elevated open platform (2006)
Journal Article
Storey, J., Robertson, D., Beattie, J., Reid, I., Mitchell, S., & Balfour, D. (2006). Behavioural and neurochemical responses evoked by repeated exposure to an elevated open platform. Behavioural Brain Research, 166(2), 220-229. https://doi.org/10.1016/j.bbr.2005.08.002

Increased psychophysiological resistance to chronic stress has been related to increased 5-HT release in the dorsal hippocampus. This study investigated the changes in 5-HT release and turnover in the hippocampus evoked by acute and repeated exposure... Read More about Behavioural and neurochemical responses evoked by repeated exposure to an elevated open platform.