All Outputs (4)

Novel cyanocombretastatins as potent tubulin polymerisation inhibitors (2012)
Journal Article
Jalily, P., Hirst, N., Hadfield, J., & Rossington, S. (2012). Novel cyanocombretastatins as potent tubulin polymerisation inhibitors. Bioorganic and Medicinal Chemistry Letters, 22(21), 6731-6734. https://doi.org/10.1016/j.bmcl.2012.08.089

A series of novel cyanocombretastatins bearing a 3,4,5-trimethoxyphenyl moiety combined with a variety of substituted phenyl rings, were synthesised and their antitumour activity was evaluated. The Z-cyanocombretastatins were synthesised in a one-ste... Read More about Novel cyanocombretastatins as potent tubulin polymerisation inhibitors.

Synthesis and evaluation of novel kinase inhibitors as anti-cancer agents (2012)
Thesis
Kemp, T. Synthesis and evaluation of novel kinase inhibitors as anti-cancer agents. (Thesis). University of Salford

Disruption of protein kinase signalling pathways is often associated with cancer. The
RhoA/ROCK kinase pathway has been shown to be constitutively expressed in many cancers
and has also been shown to be involved in metastasis and apoptosis. ROCK is... Read More about Synthesis and evaluation of novel kinase inhibitors as anti-cancer agents.

A practical radiosynthesis of a tritium-labelled fluoro combretastatin (2012)
Journal Article
Hadfield, J., Hirst, N., Mcgown, A., Lawrence, N., & Gaukroger, K. (2012). A practical radiosynthesis of a tritium-labelled fluoro combretastatin. Journal of Labelled Compounds and Radiopharmaceuticals, 55(8), 303-306. https://doi.org/10.1002/jlcr.2939

Zybrestat (combretastatin A-4 disodium diphosphate) is currently in clinical trials as an antivascular anticancer agent. A similar fluorinated agent has shown promise as an antivascular agent and a radiolabelled version would enable further understan... Read More about A practical radiosynthesis of a tritium-labelled fluoro combretastatin.

Time-resolved nanosecond fluorescence lifetime imaging and picosecond infrared spectroscopy of combretastatin A-4 in solution and in cellular systems (2012)
Journal Article
Bisby, R., Botchway, S., Greetham, G., Hadfield, J., Mcgown, A., Parker, A., …Towrie, M. (2012). Time-resolved nanosecond fluorescence lifetime imaging and picosecond infrared spectroscopy of combretastatin A-4 in solution and in cellular systems. Measurement Science and Technology, 23, 084001. https://doi.org/10.1088/0957-0233/23/8/084001

Fluorescence lifetime images of intrinsic fluorescence obtained with two-photon excitation at 630 nm are shown following uptake of a series of E-combretastatins into live cells, including human umbilical vein endothelial cells (HUVECs) that are the t... Read More about Time-resolved nanosecond fluorescence lifetime imaging and picosecond infrared spectroscopy of combretastatin A-4 in solution and in cellular systems.