All Outputs (2)

Facile synthesis and biological evaluation of chrysin derivatives (2021)
Journal Article
Omonga, N., Zia, Z., Ghanbour, H., Ragazzon-Smith, A., Foster, H., Hadfield, J., & Ragazzon, P. (2021). Facile synthesis and biological evaluation of chrysin derivatives. Journal of Chemical Research, 45(11-12), 1083-1092. https://doi.org/10.1177/17475198211057467

In this paper, novel synthetic methods, including microwave O-alkylation, were used to produce several chrysin derivatives. These compounds were purified, characterised and tested on different cell lines and bacterial strains. From this family, 7-(2,... Read More about Facile synthesis and biological evaluation of chrysin derivatives.

Syntheses of Combretastatin A‐4 and related stilbenes by using aqueous conditions (2021)
Journal Article
Barnes, N., Ahmed Mal Ullah, A., Ragazzon, P., Charafi, N., & Hadfield, J. (2021). Syntheses of Combretastatin A‐4 and related stilbenes by using aqueous conditions. ChemistrySelect, 6(28), 7082-7086. https://doi.org/10.1002/slct.202101960

Combretastatin A‐4 (CA4) is a potent anti‐mitotic and vascular disrupting agent. Organic chemists have been working to optimize the synthesis of CA4 for the past 3 decades, with methods requiring hazardous solvents and harsh reaction conditions. Here... Read More about Syntheses of Combretastatin A‐4 and related stilbenes by using aqueous conditions.