All Outputs (2)

A new mathematical model of folate homeostasis in E. coli highlights the potential importance of the folinic acid futile cycle in cell growth. (2023)
Journal Article
Morgan, A., Salcedo-Sora, J. E., & Mc Auley, M. T. (2024). A new mathematical model of folate homeostasis in E. coli highlights the potential importance of the folinic acid futile cycle in cell growth. BioSystems, 235, 105088. https://doi.org/10.1016/j.biosystems.2023.105088

Folate (vitamin B9) plays a central role in one-carbon metabolism in prokaryotes and eukaryotes. This pathway mediates the transfer of one-carbon units, playing a crucial role in nucleotide synthesis, methylation, and amino acid homeostasis. The foli... Read More about A new mathematical model of folate homeostasis in E. coli highlights the potential importance of the folinic acid futile cycle in cell growth..

Computationally Modelling Cholesterol Metabolism and Atherosclerosis (2023)
Journal Article
Davies, C., Morgan, A. E., & Mc Auley, M. T. (2023). Computationally Modelling Cholesterol Metabolism and Atherosclerosis. Biology, 12(8), 1133. https://doi.org/10.3390/biology12081133

Cardiovascular disease (CVD) is the leading cause of death globally. The underlying pathological driver of CVD is atherosclerosis. The primary risk factor for atherosclerosis is elevated low-density lipoprotein cholesterol (LDL-C). Dysregulation of c... Read More about Computationally Modelling Cholesterol Metabolism and Atherosclerosis.