All Outputs (5)

P735 Interleukin-33 induced eosinophilia restores perivascular adipose tissue function in obesity (2019)
Journal Article
Saxton, S., Potter, R., Withers, S., Grencis, R., & Heagerty, A. (2019). P735 Interleukin-33 induced eosinophilia restores perivascular adipose tissue function in obesity. European Heart Journal, 40(Supple), https://doi.org/10.1093/eurheartj/ehz747.0339

Abstract Background/Purpose Perivascular adipose tissue (PVAT) is essential in the modulation of vascular tone. Recently we have shown that resident eosinophils play a vital role in regulating PVAT function. In obesity, eosinophil numbers are reduced... Read More about P735 Interleukin-33 induced eosinophilia restores perivascular adipose tissue function in obesity.

Perivascular adipose tissue contributes to the modulation of vascular tone in vivo (2019)
Journal Article
Saxton, S., Withers, S., Nyvad, J., Mazur, A., Matchkov, V., Heagerty, A., & Aalkjær, C. (2019). Perivascular adipose tissue contributes to the modulation of vascular tone in vivo. Journal of Vascular Research, 56(6), 320-332. https://doi.org/10.1159/000502689

Perivascular adipose tissue (PVAT) reduces vascular tone in isolated arteries in vitro, however there are no studies of PVAT effects on vascular tone in vivo. In vitro adipocyte β3-adrenoceptors play a role in PVAT function via secretion of the vasod... Read More about Perivascular adipose tissue contributes to the modulation of vascular tone in vivo.

Mechanistic links between obesity, diabetes, and blood pressure : role of perivascular adipose tissue (2019)
Journal Article
Saxton, S., Clark, B., Withers, S., Eringa, E., & Heagerty, A. (2019). Mechanistic links between obesity, diabetes, and blood pressure : role of perivascular adipose tissue. Physiological Reviews, 99(4), 1701-1763. https://doi.org/10.1152/physrev.00034.2018

Obesity is increasingly prevalent and is associated with substantial cardiovascular risk. Adipose tissue distribution and morphology play a key role in determining the degree of adverse effects, and a key factor in the disease process appears to be t... Read More about Mechanistic links between obesity, diabetes, and blood pressure : role of perivascular adipose tissue.

Towards a clinically relevant model for investigation of host-microbe interactions in ventilator-associated pneumonia (2019)
Journal Article
Tompsett, A., Ngoc ngo, L., Goodhead, I., Withers, S., & Latimer, J. (2019). Towards a clinically relevant model for investigation of host-microbe interactions in ventilator-associated pneumonia. Access Microbiology, 1(1A), https://doi.org/10.1099/acmi.ac2019.po0422

Ventilator-associated pneumonia (VAP) is amongst the most common healthcare-associated infections worldwide. Current understanding of the underlying mechanisms has focussed on either the microbiological or physiological elements but host-microbe inte... Read More about Towards a clinically relevant model for investigation of host-microbe interactions in ventilator-associated pneumonia.

Emerging roles of sympathetic nerves and inflammation in perivascular adipose tissue (2019)
Journal Article
Saxton, S., Withers, S., & Heagerty, A. (2019). Emerging roles of sympathetic nerves and inflammation in perivascular adipose tissue. Cardiovascular Drugs and Therapy, 33(2), 245-259. https://doi.org/10.1007/s10557-019-06862-4

Perivascular adipose tissue (PVAT) is no longer recognised as simply a structural support for the vasculature, and we now know that PVAT releases vasoactive factors which modulate vascular function. Since the discovery of this function in 1991, PVAT... Read More about Emerging roles of sympathetic nerves and inflammation in perivascular adipose tissue.