Skip to main content

Research Repository

Advanced Search

All Outputs (6195)

MiRNAs as novel adipokines : obesity-related circulating MiRNAs influence chemosensitivity in cancer patients (2020)
Journal Article
Withers, S., Dewhurst, T., Hammond, C., & Topham, C. (2020). MiRNAs as novel adipokines : obesity-related circulating MiRNAs influence chemosensitivity in cancer patients. Non-Coding RNA, 6(1), e5. https://doi.org/10.3390/ncrna6010005

Adipose tissue is an endocrine organ, capable of regulating distant physiological processes in other tissues via the release of adipokines into the bloodstream. Recently, circulating adipose-derived microRNAs (miRNAs) have been proposed as a novel cl... Read More about MiRNAs as novel adipokines : obesity-related circulating MiRNAs influence chemosensitivity in cancer patients.

Designing probiotic therapies with broad-spectrum activity against a wildlife pathogen (2020)
Journal Article
Antwis, R., Harrison, X., Sewell, T., & Fisher, M. (2020). Designing probiotic therapies with broad-spectrum activity against a wildlife pathogen. Frontiers in Microbiology, 10, 3134. https://doi.org/10.3389/fmicb.2019.03134

Host-associated microbes form an important component of immunity that protect against infection by pathogens. Treating wild individuals with these protective microbes, known as probiotics, can reduce rates of infection and disease in both wild and... Read More about Designing probiotic therapies with broad-spectrum activity against a wildlife pathogen.

Lead optimisation of dehydroemetine for repositioned use in malaria (2020)
Journal Article
Panwar, P., Burusco, K., Abubaker, M., Matthews, H., Gutnov, A., Fernández-Álvaro, E., …Nirmalan, N. (2020). Lead optimisation of dehydroemetine for repositioned use in malaria. Antimicrobial Agents and Chemotherapy, 64(4), 1-10. https://doi.org/10.1128/AAC.01444-19

Drug repositioning offers an effective alternative to de novo drug design to tackle the urgent need for novel anti-malarial treatments. The anti-amoebic compound, emetine dihydrochloride, has been identified as a potent in-vitro inhibitor of the mult... Read More about Lead optimisation of dehydroemetine for repositioned use in malaria.

Island rule and bone metabolism in fossil murines from Timor (2020)
Journal Article
Miszkiewicz, J., Louys, J., Beck, R., Mahoney, P., Aplin, K., & O’Connor, S. (2020). Island rule and bone metabolism in fossil murines from Timor. Biological Journal of the Linnean Society, 129(3), 570-586. https://doi.org/10.1093/biolinnean/blz197

Skeletal growth rates reconstructed from bone histology in extinct insular hippopotamids, elephants, bovids and sauropods have been used to infer dwarfism as a response to island conditions. Limited published records of osteocyte lacunae densities... Read More about Island rule and bone metabolism in fossil murines from Timor.

Transport's historical, contemporary and future role in shaping urban development : re-evaluating transit oriented development (2020)
Journal Article
Knowles, R., Ferbrache, F., & Nikitas, A. (2020). Transport's historical, contemporary and future role in shaping urban development : re-evaluating transit oriented development. Cities, 99, 102607. https://doi.org/10.1016/j.cities.2020.102607

This paper reviews transport's historical, contemporary and future role in shaping urban development since industrialisation. Previous definitions of Transit Oriented Development (TOD) starting in the late 20th century are challenged. Three distinct... Read More about Transport's historical, contemporary and future role in shaping urban development : re-evaluating transit oriented development.

Complete mitochondrial DNA sequence of the parasitic honey bee mite Varroa destructor (Mesostigmata : Varroidae) (2020)
Journal Article
Harada, R., Yoshioka, M., Okuyama, H., Kato, M., Martin, S., & Takahashi, J. (2020). Complete mitochondrial DNA sequence of the parasitic honey bee mite Varroa destructor (Mesostigmata : Varroidae). Mitochondrial DNA Part B, 5(1), 635-636. https://doi.org/10.1080/23802359.2019.1711219

Varroa destructor is a parasite mite of the eastern honey bee Apis cerana, which is native to Asia. The European honey bee Apis mellifera was imported to Asia from Europe and the USA for apiculture in the 19th century. In a short period of time, V. d... Read More about Complete mitochondrial DNA sequence of the parasitic honey bee mite Varroa destructor (Mesostigmata : Varroidae).

Transcriptomic profiling disclosed the role of DNA methylation and histone modifications in tumor-infiltrating myeloid-derived suppressor cell subsets in colorectal cancer (2020)
Journal Article
Sasidharan Nair, V., Saleh, R., Toor, S., Taha, R., Ahmed, A., Kurer, M., …Elkord, E. (2020). Transcriptomic profiling disclosed the role of DNA methylation and histone modifications in tumor-infiltrating myeloid-derived suppressor cell subsets in colorectal cancer. Clinical Epigenetics, 12(1), 13. https://doi.org/10.1186/s13148-020-0808-9

Increased numbers of myeloid-derived suppressor cells (MDSCs) are positively correlated with poor prognosis and reduced survivals of cancer patients. They play central roles in tumor immune evasion and tumor metastasis. However, limited data are avai... Read More about Transcriptomic profiling disclosed the role of DNA methylation and histone modifications in tumor-infiltrating myeloid-derived suppressor cell subsets in colorectal cancer.

Using probe electrospray ionization mass spectrometry and machine learning for detecting pancreatic cancer with high performance (2020)
Journal Article
Chung, W., Correa, E., Yoshimura, K., Chang, M., Dennison, A., Takeda, S., & Chang, Y. (2020). Using probe electrospray ionization mass spectrometry and machine learning for detecting pancreatic cancer with high performance. American Journal of Translational Research, 12(1), 171-179

A rapid blood-based diagnostic modality to detect pancreatic ductal adenocarcinoma (PDAC) with high accuracy is an unmet medical need. The study aimed to validate a unique diagnosis system using Probe Electrospray Ionization Mass Spectrometry (PESI-M... Read More about Using probe electrospray ionization mass spectrometry and machine learning for detecting pancreatic cancer with high performance.

Diet choice in a generalist predator, the invasive lionfish (Pterois volitans/miles) (2020)
Journal Article
Ritger, A. L., Fountain, C. T., Bourne, K., Martín-Fernández, J. A., & Pierotti, M. E. (2020). Diet choice in a generalist predator, the invasive lionfish (Pterois volitans/miles). Journal of Experimental Marine Biology and Ecology, 524, https://doi.org/10.1016/j.jembe.2020.151311

Diet choice in marine species is typically derived from indirect methods such as stomach contents and stable isotope analysis, while choice experiments in controlled laboratory settings are used to infer foraging decisions in the wild. However, these... Read More about Diet choice in a generalist predator, the invasive lionfish (Pterois volitans/miles).

Perspective distortion modeling for image measurements (2020)
Journal Article
Bousaid, A., Theodoridis, T., Nefti-Meziani, S., & Davis, S. (2020). Perspective distortion modeling for image measurements. IEEE Access, 8, 15322-15331. https://doi.org/10.1109/ACCESS.2020.2966716

A perspective distortion modelling for monocular view that is based on the fundamentals of perspective projection is presented in this work. Perspective projection is considered to be the most ideal and realistic model among others, which depicts ima... Read More about Perspective distortion modeling for image measurements.

Sustainability ranking of desalination plants using Mamdani Fuzzy Logic Inference Systems (2020)
Journal Article
Rustum, R., Kurichiyanil, A., Forrest, S., Sommariva, C., Adeloye, A., Zounemat-Kermani, M., & Scholz, M. (2020). Sustainability ranking of desalination plants using Mamdani Fuzzy Logic Inference Systems. Sustainability, 12(2), e631. https://doi.org/10.3390/su12020631

As water desalination continues to expand globally, desalination plants are continually under pressure to meet the requirements of sustainable development. However, the majority of desalination sustainability research has focused on new desalination... Read More about Sustainability ranking of desalination plants using Mamdani Fuzzy Logic Inference Systems.

Assessing the potential of environmental DNA metabarcoding for monitoring Neotropical mammals : a case study in the Amazon and Atlantic Forest, Brazil (2020)
Journal Article
Sales, N., Da Cruz Kaizer, M., Coscia, I., Perkins, J., Highlands, A., Boubli, J., …McDevitt, A. (2020). Assessing the potential of environmental DNA metabarcoding for monitoring Neotropical mammals : a case study in the Amazon and Atlantic Forest, Brazil. Mammal Review, 50(3), 221-225. https://doi.org/10.1111/mam.12183

The application of environmental DNA (eDNA) metabarcoding as a biomonitoring tool has greatly increased in the last decade. However, most studies have focused on aquatic macro-organisms in temperate areas (e.g., fishes). We apply eDNA metabarcoding t... Read More about Assessing the potential of environmental DNA metabarcoding for monitoring Neotropical mammals : a case study in the Amazon and Atlantic Forest, Brazil.

thermogram Breast Cancer Detection : a comparative study of two machine learning techniques (2020)
Journal Article
AlFayez, F., El-Soud, M., & Gaber, T. (2020). thermogram Breast Cancer Detection : a comparative study of two machine learning techniques. Applied Sciences, 10(2), e551. https://doi.org/10.3390/app10020551

Breast cancer is considered one of the major threats for women’s health all over the world. The World Health Organization (WHO) has reported that 1 in every 12 women could be subject to a breast abnormality during her lifetime. To increase survival r... Read More about thermogram Breast Cancer Detection : a comparative study of two machine learning techniques.

Large-scale and significant expression from pseudogenes in Sodalis glossinidius – a facultative bacterial endosymbiont (2020)
Journal Article
Goodhead, I., Blow, F., Brownridge, P., Hughes, M., Kenny, J., Krishna, R., …Darby, A. (2020). Large-scale and significant expression from pseudogenes in Sodalis glossinidius – a facultative bacterial endosymbiont. Microbial Genomics, 6(1), https://doi.org/10.1099/mgen.0.000285

The majority of bacterial genomes have high coding efficiencies, but there are some genomes of intracellular bacteria that have low gene density. The genome of the endosymbiont Sodalis glossinidius contains almost 50 % pseudogenes containing mutation... Read More about Large-scale and significant expression from pseudogenes in Sodalis glossinidius – a facultative bacterial endosymbiont.

Numerical investigation into the stability of earth dam slopes considering the effects of cavities (2020)
Journal Article
Al-ateya, H., & Ahangar Asr, A. (2020). Numerical investigation into the stability of earth dam slopes considering the effects of cavities. Engineering Computations, 37(4), 1397-1421. https://doi.org/10.1108/EC-03-2019-0101

This research is an attempt to estimate the influence of the presence of cavities on the stability of slopes in earth dams under rapid drawdown conditions. The aim of the investigation is to study the influence of different factors, such as the dia... Read More about Numerical investigation into the stability of earth dam slopes considering the effects of cavities.

A global database for metacommunity ecology, integrating species, traits, environment and space (2020)
Journal Article
Jeliazkov, A., Mijatovic, D., Chantepie, S., Andrew, N., Arlettaz, R., Meyer, C., & et, A. (2020). A global database for metacommunity ecology, integrating species, traits, environment and space. Scientific Data, 7(1), 6. https://doi.org/10.1038/s41597-019-0344-7

The use of functional information in the form of species traits plays an important role in explaining biodiversity patterns and responses to environmental changes. Although relationships between species composition, their traits, and the environment... Read More about A global database for metacommunity ecology, integrating species, traits, environment and space.

Lens transmittance shapes ultraviolet sensitivity in the eyes of frogs from diverse ecological and phylogenetic backgrounds (2020)
Journal Article
Yovanovich, C. A. M., Pierotti, M. E. R., Kelber, A., Jorgewich-Cohen, G., Ibáñez, R., & Grant, T. (2020). Lens transmittance shapes ultraviolet sensitivity in the eyes of frogs from diverse ecological and phylogenetic backgrounds. Proceedings of the Royal Society B: Biological Sciences, 287(1918), https://doi.org/10.1098/rspb.2019.2253

The amount of short wavelength (ultraviolet (UV), violet and blue) light that reaches the retina depends on the transmittance properties of the ocular media, especially the lens, and varies greatly across species in all vertebrate groups studied prev... Read More about Lens transmittance shapes ultraviolet sensitivity in the eyes of frogs from diverse ecological and phylogenetic backgrounds.

BIM-based operational information requirements for asset owners (2020)
Journal Article
Munir, M., Kiviniemi, A., Jones, S., & Finnegan, S. (2020). BIM-based operational information requirements for asset owners. Architectural Engineering and Design Management, 16(2), 100-114. https://doi.org/10.1080/17452007.2019.1706439

It is widely recognised in the Architecture, Engineering and Construction (AEC) industry that asset owners do not really understand their information needs for effective BIM-based Asset Management (AM). Hence, they may be unable to develop their oper... Read More about BIM-based operational information requirements for asset owners.