All Outputs (307)

Novel cyanocombretastatins as potent tubulin polymerisation inhibitors (2012)
Journal Article
Jalily, P., Hirst, N., Hadfield, J., & Rossington, S. (2012). Novel cyanocombretastatins as potent tubulin polymerisation inhibitors. Bioorganic and Medicinal Chemistry Letters, 22(21), 6731-6734. https://doi.org/10.1016/j.bmcl.2012.08.089

A series of novel cyanocombretastatins bearing a 3,4,5-trimethoxyphenyl moiety combined with a variety of substituted phenyl rings, were synthesised and their antitumour activity was evaluated. The Z-cyanocombretastatins were synthesised in a one-ste... Read More about Novel cyanocombretastatins as potent tubulin polymerisation inhibitors.

Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer (2012)
Journal Article
Tucci, P., Agostini, M., Grespi, F., Merkert, E., Terrinoni, A., Vousden, K., …Sayan, B. (2012). Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer. Proceedings of the National Academy of Sciences, 109(38), https://doi.org/10.1073/pnas.1110977109

p63 inhibits metastasis. Here, we show that p63 (both TAp63 and ΔNp63 isoforms) regulates expression of miR-205 in prostate cancer (PCa) cells, and miR-205 is essential for the inhibitory effects of p63 on markers of epithelial–mesenchymal transition... Read More about Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer.

Investment appraisal tools and sustainability evaluation in social housing (2012)
Presentation / Conference
Higham, A., & Fortune, C. (2012, September). Investment appraisal tools and sustainability evaluation in social housing. Presented at Association of Researchers in Construction Management (ARCOM) 28th Annual Conference, Edinburgh

Conventional decision making in all aspects of the asset management sector has largely been based around the key concepts of risk reduction and maximization of returns. Yet the RICS (2009) has called for surveying professionals to significantly modif... Read More about Investment appraisal tools and sustainability evaluation in social housing.

Attaining zero defects within Building Schools for the Future : A realistic target or a Sisyphean task? (2012)
Presentation / Conference
Higham, A., Boothman, J., & Horsfall, B. (2012, September). Attaining zero defects within Building Schools for the Future : A realistic target or a Sisyphean task?. Presented at 27th Annual Association of Researchers in Construction Management (ARCOM) Conference, Edinburgh, UK

Until its demise in July 2010 The Building Schools for the Future (BSF) programme represented the biggest single UK government investment in school buildings for more than 50 years. One of the key goals of the investment programme was the desire to e... Read More about Attaining zero defects within Building Schools for the Future : A realistic target or a Sisyphean task?.

Engaging life in two Irish nursing home units for people with dementia : quantitative comparisons before and after implementing household environments (2012)
Journal Article
Morgan_Brown, M., Ormerod, M., & Newton, R. (2012). Engaging life in two Irish nursing home units for people with dementia : quantitative comparisons before and after implementing household environments. Aging & mental health, 17(1), 57-65. https://doi.org/10.1080/13607863.2012.717250

This study compares the Social Engagement and Interactive Occupation of residents with dementia in two Irish nursing homes, before and after conversion to a household model environment. The changes were an open plan design and a functioning unit kitc... Read More about Engaging life in two Irish nursing home units for people with dementia : quantitative comparisons before and after implementing household environments.

Impacts of flooding on SMEs and their relevance to chartered surveyors : final report of the developing flood expert knowledge in chartered surveyors - DEFENCES project (2012)
Report
Wedawatta, H., Ingirige, B., & Proverbs, D. (2012). Impacts of flooding on SMEs and their relevance to chartered surveyors : final report of the developing flood expert knowledge in chartered surveyors - DEFENCES project

The UK has endured a number of major flood events in recent years, and the UK Environment Agency (2009a) identified that about 5.2million properties in England, amounting to one in six, are at risk of flooding. The impacts of flooding include d... Read More about Impacts of flooding on SMEs and their relevance to chartered surveyors : final report of the developing flood expert knowledge in chartered surveyors - DEFENCES project.

Lean healthcare : the success of a toolkit depends also on the people who use the tools (2012)
Journal Article
Rooke, J., Koskela, L., & Kagioglou, M. (2012). Lean healthcare : the success of a toolkit depends also on the people who use the tools. Annals of Emergency Medicine, 60(3), 395-396. https://doi.org/10.1016/j.annemergmed.2012.01.038

Time domain analysis of Helmholtz soliton propagation using the TLM method (2012)
Journal Article
Chamorro-Posada, P., & McDonald, G. (2012). Time domain analysis of Helmholtz soliton propagation using the TLM method. Journal of Nonlinear Optical Physics and Materials, 21(03), https://doi.org/10.1142/S0218863512500312

The transmission line matrix method is used to study Helmholtz solitons as solutions of the two-dimensional time-domain Maxwell equations in nonlinear media. This approach permits to address, in particular, the propagation and intrinsic stability pr... Read More about Time domain analysis of Helmholtz soliton propagation using the TLM method.

Modelling stress-strain and volume change behaviour of unsaturated soils using an evolutionary based data mining technique, an incremental approach (2012)
Journal Article
Javadi, A., Ahangar-Asr, A., Johari, A., Faramarzi, A., & Toll, D. (2012). Modelling stress-strain and volume change behaviour of unsaturated soils using an evolutionary based data mining technique, an incremental approach. Engineering Applications of Artificial Intelligence, 25(5), 926-933. https://doi.org/10.1016/j.engappai.2012.03.006

Modelling of unsaturated soils has been the subject of many research works in the past few decades. A number of constitutive models have been developed to describe the complex behaviour of unsaturated soils. However, many have proven to be unable to... Read More about Modelling stress-strain and volume change behaviour of unsaturated soils using an evolutionary based data mining technique, an incremental approach.

Determination of the most probable slip surface in 3D slopes considering the effect of earthquake force direction (2012)
Journal Article
Ahangar-Asr, A., Toufigh, M., & Salajegheh, A. (2012). Determination of the most probable slip surface in 3D slopes considering the effect of earthquake force direction. Computers and Geosciences, 45, 119-130. https://doi.org/10.1016/j.cageo.2011.10.024

Considering the effect of earthquake forces on stability of slopes has always been of crucial importance in seismic analysis of geotechnical structures like dams, roads and embankments and there has been much concern about stability of cuts, fills an... Read More about Determination of the most probable slip surface in 3D slopes considering the effect of earthquake force direction.

An EPR Approach to the Modeling of Civil and Geotechnical Engineering Systems (2012)
Book Chapter
Javadi, A. A., Ahangar-Asr, A., Faramarzi, A., & Mottaghifard, N. (2013). An EPR Approach to the Modeling of Civil and Geotechnical Engineering Systems. In Metaheuristics in Water, Geotechnical and Transport Engineering (311-326). Elsevier. https://doi.org/10.1016/B978-0-12-398296-4.00013-1

Enhancing Surface Enhanced Raman Scattering (SERS) detection of propranolol with multiobjective evolutionary optimization (2012)
Journal Article
Levene, C., Correa, E., Blanch, E., & Goodacre, R. (2012). Enhancing Surface Enhanced Raman Scattering (SERS) detection of propranolol with multiobjective evolutionary optimization. Analytical Chemistry, 84(18), 7899-7905. https://doi.org/10.1021/ac301647a

Colloidal-based surface-enhanced Raman scattering (SERS) is a complex technique, where interaction between multiple parameters, such as colloid type, its concentration, and aggregating agent, is poorly understood. As a result SERS has so far achieved... Read More about Enhancing Surface Enhanced Raman Scattering (SERS) detection of propranolol with multiobjective evolutionary optimization.

Haptic needle as part of medical training simulator (2012)
Patent
Hughes, C., & John, N. (2012). Haptic needle as part of medical training simulator

Resilience and adaptation of small and medium-sized enterprises to flood risk (2012)
Journal Article
Wedawatta, G., & Ingirige, B. (2012). Resilience and adaptation of small and medium-sized enterprises to flood risk. Disaster Prevention and Management, 21(4), 474-488. https://doi.org/10.1108/09653561211256170

Purpose – The UK has experienced a number of flood events in recent years, and the intensity and frequency of such events are forecast to further increase in future due to changing climatic conditions. Accordingly, enhancing the resilience of small a... Read More about Resilience and adaptation of small and medium-sized enterprises to flood risk.

What are the ingredients of successful travel behavioural change campaigns? (2012)
Journal Article
Davies, N. (2012). What are the ingredients of successful travel behavioural change campaigns?. Transport Policy, 24, 19-29. https://doi.org/10.1016/j.tranpol.2012.06.017

An examination of the evidence from twenty case studies of behavioural change projects identifies common and specific elements which led to their success. Using evidence from a recent EU project, the paper discusses the design of travel behaviour cha... Read More about What are the ingredients of successful travel behavioural change campaigns?.

Reproducibility of soundscape dimensions (2012)
Presentation / Conference
Davies, W., & Murphy, J. (2012, August). Reproducibility of soundscape dimensions. Presented at Internoise 2012, New York

The aim of this work was to investigate the validity of laboratory soundscape reproduction and the robustness of soundscape dimensional analysis. The soundscapes in four urban locations in Manchester (UK) were recorded with a soundfield microphone. T... Read More about Reproducibility of soundscape dimensions.

On the assessment of the human exposure from vibration caused by railway construction (2012)
Presentation / Conference
Sica, G., Woodcock, J., Peris, E., Moorhouse, A., Waddington, D., & Peris, E. (2012, August). On the assessment of the human exposure from vibration caused by railway construction. Presented at Internoise 2012, New York

When constructing large infrastructure, such as railways, close to living environments it is important to know how residents respond to construction vibration. In this framework, the University of Salford, within the project “Human response to vibrat... Read More about On the assessment of the human exposure from vibration caused by railway construction.

Attitudinal factors as determinants of railway vibration annoyance (2012)
Presentation / Conference
Peris, E., Woodcock, J., Sica, G., Sharp, C., Moorhouse, A., Waddington, D., & Peris, E. (2012, August). Attitudinal factors as determinants of railway vibration annoyance. Presented at Internoise 2012, New York

The aim of this paper is to identify and understand the role of the attitudinal factors involved in annoyance reported due to railway vibration. Many non-acoustical factors have been identified with various degrees of association with annoyance due t... Read More about Attitudinal factors as determinants of railway vibration annoyance.

Is production outside management? (2012)
Journal Article
Koskela, L., & Ballard, G. (2012). Is production outside management?. Building Research and Information, 40(6), 724-737. https://doi.org/10.1080/09613218.2012.709373

It is contended that the root cause for disagreement between lean construction proponents and management scholars is related to the new direction of management research which was proposed in 1959 in two influential books, by R.A.Gordon and J.E. Howel... Read More about Is production outside management?.

Study on the visual performance of a traditional residential neighbourhood in Old Cairo (2012)
Journal Article
Al-Maiyah, S., & Elkadi, H. (2012). Study on the visual performance of a traditional residential neighbourhood in Old Cairo. Journal of Urban Technology, 19(4), 59-86. https://doi.org/10.1080/10630732.2011.649913%3FjournalCode%3Dcjut20

Traditional dwellings located in the hot arid zone in Egypt are well known for their sensitive architectural response to the region’s climatic conditions and socio-cultural norms. The majority of these dwellings are well recognized for their courtyar... Read More about Study on the visual performance of a traditional residential neighbourhood in Old Cairo.