All Outputs (26)

Membrane permeability and regulation of drug "influx and efflux" in enterobacterial pathogens. (2008)
Journal Article
Davin-Regli, A., Bolla, J., James, C., Lavigne, J., Chevalier, J., Garnotel, E., …Pagès, J. (2008). Membrane permeability and regulation of drug "influx and efflux" in enterobacterial pathogens. Current Drug Targets, 9(9), 750-759. https://doi.org/10.2174/138945008785747824

In Enterobacteriaceae, membrane permeability is a key in the level of susceptibility to antibiotics. Modification of the bacterial envelope by decreasing the porin production or increasing the expression of efflux pump systems has been reported. Thes... Read More about Membrane permeability and regulation of drug "influx and efflux" in enterobacterial pathogens..

The porin and the permeating antibiotic: A selective diffusion barrier in gram-negative bacteria (2008)
Journal Article
Pages, J., James, C., & Winterhalter, M. (2008). The porin and the permeating antibiotic: A selective diffusion barrier in gram-negative bacteria. Nature Reviews Microbiology, 6, 893-903. https://doi.org/10.1038/nrmicro1994

Gram-negative bacteria are responsible for a large proportion of antibiotic resistant bacterial diseases. These bacteria have a complex cell envelope that comprises an outer membrane and an inner membrane that delimit the periplasm. The outer membran... Read More about The porin and the permeating antibiotic: A selective diffusion barrier in gram-negative bacteria.

Short-tailed stx phages exploit the conserved YaeT protein to disseminate shiga toxin genes among enterobacteria (2007)
Journal Article
Smith, D. L., James, C., Sergeant, M., Yaxian, Y., Saunders, J. R., McCarthy, A. J., & Allison, H. (2007). Short-tailed stx phages exploit the conserved YaeT protein to disseminate shiga toxin genes among enterobacteria. Journal of Bacteriology, 189, 7223-7233. https://doi.org/10.1128/JB.00824-07

Infection of Escherichia coli by Shiga toxin-encoding bacteriophages (Stx phages) was the pivotal event in the evolution of the deadly Shiga toxin-encoding E. coli (STEC), of which serotype O157:H7 is the most notorious. The number of different bacte... Read More about Short-tailed stx phages exploit the conserved YaeT protein to disseminate shiga toxin genes among enterobacteria.

An early response to environmental stress involves regulation of OmpX and OmpF, two enterobacterial outer membrane pore-forming proteins (2007)
Journal Article
Dupont, M., James, C., Chevalier, J., & Pages, J. (2007). An early response to environmental stress involves regulation of OmpX and OmpF, two enterobacterial outer membrane pore-forming proteins. Antimicrobial Agents and Chemotherapy, 51(9), 3190-3198. https://doi.org/10.1128/AAC.01481-06

Bacterial adaptation to external stresses and toxic compounds is a key step in the emergence of multidrug-resistant strains that are a serious threat to human health. Although some of the proteins and regulators involved in antibiotic resistance mech... Read More about An early response to environmental stress involves regulation of OmpX and OmpF, two enterobacterial outer membrane pore-forming proteins.

HIV protease inhibitors are substrates for OATP1A2, OATP1B1 and OATP1B3 and lopinavir plasma concentrations are influenced by SLCO1B1 polymorphisms
Journal Article
Hartkoorn, R., Kwan, W., Shallcross, V., Chaikan, A., Liptrott, N., Egan, D., …Owen, A. HIV protease inhibitors are substrates for OATP1A2, OATP1B1 and OATP1B3 and lopinavir plasma concentrations are influenced by SLCO1B1 polymorphisms. Pharmacogenetics and Genomics, 20(2), 112-120. https://doi.org/10.1097/FPC.0b013e328335b02d

OBJECTIVE: OATP1B1 and OATP1B3 are major hepatic drug transporters whilst OATP1A2 is mainly located in the brain but is also located in liver and several other organs. These transporters affect the distribution and clearance of many endobiotics and x... Read More about HIV protease inhibitors are substrates for OATP1A2, OATP1B1 and OATP1B3 and lopinavir plasma concentrations are influenced by SLCO1B1 polymorphisms.

Novel therapeutic strategies to counter pseudomonas aeruginosa infections
Journal Article
Fothergill, J., Winstanley, C., & James, C. Novel therapeutic strategies to counter pseudomonas aeruginosa infections. Expert Review of Anti-infective Therapy, 10(2), 219-235. https://doi.org/10.1586/eri.11.168

Pseudomonas aeruginosa is a highly successful opportunistic pathogen that displays intrinsic multidrug resistance and has a tremendous capacity to acquire further resistance mechanisms. During chronic infection, the bacterium can form a protective... Read More about Novel therapeutic strategies to counter pseudomonas aeruginosa infections.