Dr Darren Brooks' Outputs (9)

Proline-specific aminopeptidase P prevents replication-associated genome instability (2022)
Journal Article
Silva, N., Castellano-Pozo, M., Matsuzaki, K., Barroso, C., Roman-Trufero, M., Craig, H., …Martinez-Perez, E. (2022). Proline-specific aminopeptidase P prevents replication-associated genome instability. PLoS Genetics, 18(1), e1010025. https://doi.org/10.1371/journal.pgen.1010025

Genotoxic stress during DNA replication constitutes a serious threat to genome integrity and causes human diseases. Defects at different steps of DNA metabolism are known to induce replication stress, but the contribution of other aspects of cellular... Read More about Proline-specific aminopeptidase P prevents replication-associated genome instability.

Fungal microbiomes are determined by host phylogeny and exhibit widespread associations with the bacterial microbiome (2021)
Journal Article
Harrison, X., McDevitt, A., Dunn, J., Grifftihs, S., Benvenuto, C., Birtles, R., …Antwis, R. (2021). Fungal microbiomes are determined by host phylogeny and exhibit widespread associations with the bacterial microbiome. Proceedings of the Royal Society B: Biological Sciences, 288(1957), 20210552. https://doi.org/10.1098/rspb.2021.0552

Interactions between hosts and their resident microbial communities are a fundamental component of fitness for both agents. Though recent research has highlighted the importance of interactions between animals and their bacterial communities, compara... Read More about Fungal microbiomes are determined by host phylogeny and exhibit widespread associations with the bacterial microbiome.

Toxoplasma gondii: Prevalence in species and genotypes of British bats (Pipistrellus pipistrellus and P. pygmaeus) (2014)
Journal Article
Dodd, N. S., Lord, J. S., Jehle, R., Parker, S., Parker, F., Brooks, D. R., & Hide, G. (2014). Toxoplasma gondii: Prevalence in species and genotypes of British bats (Pipistrellus pipistrellus and P. pygmaeus). Experimental Parasitology, 139, 6-11. https://doi.org/10.1016/j.exppara.2014.02.007

Few studies have investigated Toxoplasma gondii infections in bat populations and none have reported its
presence in protected British bat species. Using a collection of dead/euthanased bats collected from Lancashire,
UK, two species of bats (Pipis... Read More about Toxoplasma gondii: Prevalence in species and genotypes of British bats (Pipistrellus pipistrellus and P. pygmaeus).

Toxoplasma gondii : prevalence in species and genotypes of British bats (Pipistrellus pipistrellus and P. pygmaeus) (2014)
Journal Article
Dodd, N., Lord, J., Jehle, R., Parker, S., Parker, F., Brooks, D., & Hide, G. (2014). Toxoplasma gondii : prevalence in species and genotypes of British bats (Pipistrellus pipistrellus and P. pygmaeus). Experimental Parasitology, 139, 6-11. https://doi.org/10.1016/j.exppara.2014.02.007

Few studies have investigated Toxoplasma gondii infections in bat populations and none have reported its
presence in protected British bat species. Using a collection of dead/euthanased bats collected from Lancashire,
UK, two species of bats (Pipis... Read More about Toxoplasma gondii : prevalence in species and genotypes of British bats (Pipistrellus pipistrellus and P. pygmaeus).

Unravelling the moulting degradome: new opportunities for chemotherapy? (2007)
Journal Article
Craig, H., Isaac, R., & Brooks, D. (2007). Unravelling the moulting degradome: new opportunities for chemotherapy?. Trends in Parasitology, 23(6), 248-253. https://doi.org/10.1016/j.pt.2007.04.003

Replacement of the nematode cuticle with a newly synthesized cuticle (a process known as moulting) occurs four times during larval development. Therefore, the key components of this essential developmental process represent attractive targets for new... Read More about Unravelling the moulting degradome: new opportunities for chemotherapy?.

Pathogenicity and protective immunogenicity of cysteine proteinase-deficient mutants of Leishmania mexicana in non-murine models (2006)
Journal Article
Saravia, N., Escoria, B., Osorio, Y., Valderramaa, L., Brooks, D., Arteaga, L., …Travi, B. (2006). Pathogenicity and protective immunogenicity of cysteine proteinase-deficient mutants of Leishmania mexicana in non-murine models. Vaccine, 24(19), 4247-4259. https://doi.org/10.1016/j.vaccine.2005.05.045

This study demonstrates that deletion of cysteine proteinase (CP) genes diminishes pathogenicity of Leishmania mexicana in non-murine experimental host models while preserving immunogenicity. Both cpb and cpa/cpb-deficient lines induced delayed disea... Read More about Pathogenicity and protective immunogenicity of cysteine proteinase-deficient mutants of Leishmania mexicana in non-murine models.

An essential role in molting and morphogenesis of Caenorhabditis elegans for ACN-1, a novel member of the angiotensis-converting enzyme family that lacks a metallopeptidase active site (2003)
Journal Article
Brooks, D., Appleford, P., Murray, L., & Isaac, R. (2003). An essential role in molting and morphogenesis of Caenorhabditis elegans for ACN-1, a novel member of the angiotensis-converting enzyme family that lacks a metallopeptidase active site. Journal of Biological Chemistry, 278(52), 52340-52346. https://doi.org/10.1074/jbc.M308858200

Genome sequence analyses predict many proteins that are structurally related to proteases but lack catalytic residues, thus making functional assignment difficult. We show that one of these proteins (ACN-1), a unique multi-domain angiotensin-converti... Read More about An essential role in molting and morphogenesis of Caenorhabditis elegans for ACN-1, a novel member of the angiotensis-converting enzyme family that lacks a metallopeptidase active site.

The Caenorhabditis elegans orthologue of mammalian puromycinsensitive aminepeptidas has roles in embryogenesis and reproduction (2003)
Journal Article
Brooks, D., Hooper, N., & Isaac, R. (2003). The Caenorhabditis elegans orthologue of mammalian puromycinsensitive aminepeptidas has roles in embryogenesis and reproduction. Journal of Biological Chemistry, 278(44), 42795-42801. https://doi.org/10.1074/jbc.M306216200

Mammals possess membrane-associated and cytosolic forms of the puromycin-sensitive aminopeptidase (PSA; EC 3.4.11.14). Increasing evidence suggests the membrane PSA is involved in neuromodulation within the central nervous system and in reproductive... Read More about The Caenorhabditis elegans orthologue of mammalian puromycinsensitive aminepeptidas has roles in embryogenesis and reproduction.

The stage-regulated expression of leishmania mexicana CPB cysteine proteases is mediated by an intercistronic sequence element (2001)
Journal Article
Brooks, D., Denise, H., Westrop, G., Coombs, G., & Mottram, J. (2001). The stage-regulated expression of leishmania mexicana CPB cysteine proteases is mediated by an intercistronic sequence element. Journal of Biological Chemistry, 276(50), 47061-47069. https://doi.org/10.1074/jbc.M108498200

The tandemly-arranged CPB genes of Leishmania mexicana are polycistronically transcribed and encode cysteine proteases that are differentially stage-specific; CPB1 and CPB2 being expressed predominantly in metacyclics whereas CPB3-CPB18 are expressed... Read More about The stage-regulated expression of leishmania mexicana CPB cysteine proteases is mediated by an intercistronic sequence element.