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The student perspective of a research-informed teaching activity using simulation (2024)
Presentation / Conference
Higgins, R., Kaushik, C., & Szczepura​, K. (2024, June). The student perspective of a research-informed teaching activity using simulation. Presented at United Kingdom Imaging and Oncology Congress 2024, Liverpool

Background: The opening of the new £3 million Centre for Medical Imaging within the University offered a novel opportunity for students to design a survey tool and collect data that compared the two new X-ray imaging rooms – one that has been designe... Read More about The student perspective of a research-informed teaching activity using simulation.

Understanding experiences of the radiography workforce delivering medical imaging as part of patients' end of life care: An exploratory qualitative interview study. (2023)
Journal Article
Spacey, A., Heaslip, V., & Szczepura, K. (2024). Understanding experiences of the radiography workforce delivering medical imaging as part of patients' end of life care: An exploratory qualitative interview study. Radiography, 30(1), 132-140. https://doi.org/10.1016/j.radi.2023.10.019

People nearing the end of life often require medical imaging in hospitals to manage symptoms and care, despite this little is known about the experiences of those delivering it. The aim of this study is therefore to explore the experiences of the rad... Read More about Understanding experiences of the radiography workforce delivering medical imaging as part of patients' end of life care: An exploratory qualitative interview study..

Skin tears in mammography: A narrative review (2023)
Journal Article
Khan, A., Pradeep, S., Wynn, M., Szczepura, K., Mercer, C., & Stephens, M. (2023). Skin tears in mammography: A narrative review. Journal of Tissue Viability, 32(4), 577-584. https://doi.org/10.1016/j.jtv.2023.09.003

Skin tears are classed as traumatic wounds mainly caused by shearing and frictional forces. Incidences of skin tears are noted to be significant mostly in the elderly population and those with fragile and vulnerable skin. Individuals undergoing mammo... Read More about Skin tears in mammography: A narrative review.

Practical Mammography (2022)
Book Chapter
Mercer, C., Szczepura, K., Hill, C., Kinnear, L., & Smith, H. (2022). Practical Mammography. In Digital Mammography A Holistic Approach (295-307). Springer, Cham

Positioning for a mammogram requires skill and expertise. This chapter considers the requirements of a practitioner to employ accurate and reproducible positioning techniques whilst applying appropriate and effective compression. This chapter also il... Read More about Practical Mammography.

Assessing the impact of binaural and non-binaural auditory beat intervention to pain and compression in mammography (2022)
Journal Article
Nelson, D., Berry, R., Szczepura, K., & Mercer, C. (2022). Assessing the impact of binaural and non-binaural auditory beat intervention to pain and compression in mammography. Radiography, 29(1), 101-108. https://doi.org/10.1016/j.radi.2022.09.005

Pain and discomfort has a negative impact on a patient's overall experience and may impact on subsequent re-attendance to mammography. Pain during mammography remains a significant issue. Assessment of interventions to reduce levels of pain associate... Read More about Assessing the impact of binaural and non-binaural auditory beat intervention to pain and compression in mammography.

The diagnostic value and accuracy of ultrasound in diagnosing hydatidiform mole: A systematic review and meta-analysis of the literature. (2022)
Journal Article
Newhouse, I., Spacey, A., Scragg, B., & Szczepura, K. (2022). The diagnostic value and accuracy of ultrasound in diagnosing hydatidiform mole: A systematic review and meta-analysis of the literature. Radiography, 28(4), 897-905. https://doi.org/10.1016/j.radi.2022.06.005

Hydatidiform moles are the most common type of gestational trophoblastic disease. Internationally the incidence of hydatidiform moles is 1-2:1000 pregnancies. Early detection of women with hydatidiform moles is preferential, as these women are at a h... Read More about The diagnostic value and accuracy of ultrasound in diagnosing hydatidiform mole: A systematic review and meta-analysis of the literature..

Evaluation of the effect of breast implants on the accuracy of the CT attenuation Correction (CTAC) map for SPECT/CT myocardial perfusion imaging: a phantom study (2022)
Thesis
Alanezi, A. Evaluation of the effect of breast implants on the accuracy of the CT attenuation Correction (CTAC) map for SPECT/CT myocardial perfusion imaging: a phantom study. (Thesis). University of Salford

Background: Myocardial perfusion imaging (MPI) using single photon emission computed tomography (SPECT) imaging can assess myocardial viability and perfusion. However, overlying thoracic structures, such as ribs or breast tissue lead to gamma ray a... Read More about Evaluation of the effect of breast implants on the accuracy of the CT attenuation Correction (CTAC) map for SPECT/CT myocardial perfusion imaging: a phantom study.

Evaluation of image receptor angulation during mediolateral oblique positioning for optimised pressure and area distribution in mammography (2022)
Thesis
Osmanu, M. Evaluation of image receptor angulation during mediolateral oblique positioning for optimised pressure and area distribution in mammography. (Thesis). University of Salford

Background Mammography is the gold standard diagnostic tool for the screening and diagnosis of breast cancer; however, it is associated with pain and discomfort. The pain and discomfort are mostly due to positioning and the compression applied durin... Read More about Evaluation of image receptor angulation during mediolateral oblique positioning for optimised pressure and area distribution in mammography.

The impact of viewing conditions on image quality assessment tasks in mammographic quality control (2021)
Thesis
Papathanasiou, S. The impact of viewing conditions on image quality assessment tasks in mammographic quality control. (Thesis). University of Salford

Objective: Mammography is a technically demanding x-ray examination requiring optimal image quality to enable the early detection of breast cancer. Quality control (QC) processes ensure that the equipment in the diagnostic imaging process is functi... Read More about The impact of viewing conditions on image quality assessment tasks in mammographic quality control.

Towards optimisation of compression force in mammography (2019)
Thesis
Szczepura, K. Towards optimisation of compression force in mammography. (Thesis). University of Salford

This work focusses on the compression force applied to the breast during mammographic imaging. The lack of guidance and evidence base has led to variability in practice, and the implications of this will be discussed. All research was carried out on... Read More about Towards optimisation of compression force in mammography.

Hounsfield Unit inaccuracy in computed tomography lesion size and density, diagnostic quality vs attenuation correction (2017)
Journal Article
Szczepura, K., Thompson, J., & Manning, D. (2017). Hounsfield Unit inaccuracy in computed tomography lesion size and density, diagnostic quality vs attenuation correction. Proceedings of SPIE, 10136, https://doi.org/10.1117/12.2254275

In computed tomography the Hounsfield Units (HU) are used as an indicator of the tissue type based on the linear attenuation coefficients of the tissue. HU accuracy is essential when this metric is used in any form to support diagnosis. In hybrid ima... Read More about Hounsfield Unit inaccuracy in computed tomography lesion size and density, diagnostic quality vs attenuation correction.

Impact of tube current modulation on lesion conspicuity index in hi-resolution chest computed tomography (2017)
Journal Article
Szczepura, K., Tomkinson, D., & Manning, D. (2017). Impact of tube current modulation on lesion conspicuity index in hi-resolution chest computed tomography. Proceedings of SPIE, 10136, https://doi.org/10.1117/12.2254256

Tube current modulation is a method employed in the use of CT in an attempt to optimize radiation dose to the patient. The acceptable noise (noise index) can be varied, based on the level of optimization required; higher accepted noise reduces the pa... Read More about Impact of tube current modulation on lesion conspicuity index in hi-resolution chest computed tomography.

Effects of increased compression with an ultrasound transducer on the conspicuity of breast lesions in a phantom (2017)
Journal Article
Szczepura, K., Faqir, T., & Manning, D. (2017). Effects of increased compression with an ultrasound transducer on the conspicuity of breast lesions in a phantom. Proceedings of SPIE, 10136, https://doi.org/10.1117/12.2254263

Ultrasound imaging of the breast is highly operator dependent. The amount of pressure applied with the transducer has a direct impact on the lesion visibility in breast ultrasound. The conspicuity index is a quantitative measure of lesion visibility,... Read More about Effects of increased compression with an ultrasound transducer on the conspicuity of breast lesions in a phantom.

A JAFROC study of nodule detection performance in CT images of a thorax acquired during PET/CT (2017)
Journal Article
Thompson, J., Wareing, A., Szczepura, K., Vinjamuri, S., & Hogg, P. (2017). A JAFROC study of nodule detection performance in CT images of a thorax acquired during PET/CT. Radiography, 23(3), 191-196. https://doi.org/10.1016/j.radi.2017.03.001

Purpose Two types of CT images (modalities) are acquired in PET/CT: for attenuation correction (AC) and diagnosis. The purpose of the study was to compare nodule detection and localization performance between these two modalities. Methods CT... Read More about A JAFROC study of nodule detection performance in CT images of a thorax acquired during PET/CT.

Analysis of effective and organ dose estimation in CT when using mA modulation : a single scanner pilot study (2017)
Journal Article
Tootell, A., Szczepura, K., & Hogg, P. (2017). Analysis of effective and organ dose estimation in CT when using mA modulation : a single scanner pilot study. Radiography, 23(2), 159-166. https://doi.org/10.1016/j.radi.2017.02.006

Effective dose (ED) estimation in CT examinations can be obtained by combining dose length product (DLP) with published ED per DLP coefficients or performed using software. These methods do not account for tube current (mA) modulation which is influe... Read More about Analysis of effective and organ dose estimation in CT when using mA modulation : a single scanner pilot study.

Effective dose and effective risk from post-SPECT imaging of the lumbar spine (2016)
Journal Article
Tootell, A., McEntee, M., Szczepura, K., & Hogg, P. (2016). Effective dose and effective risk from post-SPECT imaging of the lumbar spine. Journal of Medical Imaging and Radiation Sciences, 47(3), 267-275. https://doi.org/10.1016/j.jmir.2016.04.012

Purpose Planar bone scans play an important role in the staging and monitoring of malignancy and metastases. Metastases in the lumbar spine are associated with significant morbidity, therefore accurate diagnosis is essential. Supplementary imaging... Read More about Effective dose and effective risk from post-SPECT imaging of the lumbar spine.

Validated novel software to measure the conspicuity index of lesions in DICOM images (2016)
Journal Article
Szczepura, K., & Manning, D. (2016). Validated novel software to measure the conspicuity index of lesions in DICOM images. Proceedings of SPIE, 9787, https://doi.org/10.1117/12.2216211

Description of purpose A novel software programme and associated Excel spreadsheet has been developed to provide an objective measure of the expected visual detectability of focal abnormalities within DICOM images. Methodology ROIs are drawn ar... Read More about Validated novel software to measure the conspicuity index of lesions in DICOM images.

Effect of reconstruction methods and x-ray tube current-time product on nodule detection in an anthropomorphic thorax phantom : a crossed-modality JAFROC observer study (2016)
Journal Article
Thompson, J., Chakraborty, D., Szczepura, K., Tootell, A., Vamvakas, I., Manning, D., & Hogg, P. (2016). Effect of reconstruction methods and x-ray tube current-time product on nodule detection in an anthropomorphic thorax phantom : a crossed-modality JAFROC observer study. Medical Physics, 43(3), 1265-1274. https://doi.org/10.1118/1.4941017

Purpose: To evaluate nodule detection in an anthropomorphic chest phantom in computed tomography (CT) images reconstructed with adaptive iterative dose reduction 3D (AIDR3D) and filtered back projection (FBP) over a range of tube current-time product... Read More about Effect of reconstruction methods and x-ray tube current-time product on nodule detection in an anthropomorphic thorax phantom : a crossed-modality JAFROC observer study.

Does elevating image receptor increase breast receptor footprint and improve pressure balance? (2015)
Journal Article
Smith, H., Szczepura, K., Mercer, C., Maxwell, A., & Hogg, P. (2015). Does elevating image receptor increase breast receptor footprint and improve pressure balance?. Radiography, 21(4), 359-363. https://doi.org/10.1016/j.radi.2015.02.001

There is no consensus in the literature regarding the image receptor (IR) position for the cradio-caudal projection in mammography. Some literature indicates the IR should be positioned to the infra mammary fold (IMF); other literature suggests the... Read More about Does elevating image receptor increase breast receptor footprint and improve pressure balance?.

A phantom-based JAFROC observer study of two CT reconstruction methods : the search for optimisation of lesion detection and effective dose (2015)
Journal Article
Mello-Thoms, C., Kupinski, M., Thompson, J., Chakraborty, D., Szczepura, K., Vamvakas, I., …Hogg, P. (2015). A phantom-based JAFROC observer study of two CT reconstruction methods : the search for optimisation of lesion detection and effective dose. Proceedings of SPIE, 9416, 94160B. https://doi.org/10.1117/12.2081632

Purpose: To investigate the dose saving potential of iterative reconstruction (IR) in a computed tomography (CT) examination of the thorax. Materials and Methods: An anthropomorphic chest phantom containing various configurations of simulated lesi... Read More about A phantom-based JAFROC observer study of two CT reconstruction methods : the search for optimisation of lesion detection and effective dose.

Comparison of effective dose and lifetime risk of cancer Incidence of CT attenuation correction acquisitions and radiopharmaceutical administration for myocardial perfusion imaging (2014)
Journal Article
Tootell, A., Szczepura, K., & Hogg, P. (2014). Comparison of effective dose and lifetime risk of cancer Incidence of CT attenuation correction acquisitions and radiopharmaceutical administration for myocardial perfusion imaging. British Journal of Radiology, 87(1041), 20140110. https://doi.org/10.1259/bjr.20140110

Objective: To measure the organ dose and calculate effective dose from CT attenuation correction (CTAC) acquisitions from four commonly used gamma camera single photon emission CT/CT systems. Methods: CTAC dosimetry data was collected using therm... Read More about Comparison of effective dose and lifetime risk of cancer Incidence of CT attenuation correction acquisitions and radiopharmaceutical administration for myocardial perfusion imaging.

A 6 year study of mammographic compression force : practitioner variability within and between screening sites (2014)
Journal Article
Mercer, C., Szczepura, K., Kelly, J., Millington, S., Denton, D., Borgen, R., …Hogg, P. (2015). A 6 year study of mammographic compression force : practitioner variability within and between screening sites. Radiography, 21(1), 68-73. https://doi.org/10.1016/j.radi.2014.07.004

Background The application of compression force in mammography is more heavily influenced by the practitioner rather than the client. This can affect client experience, radiation dose and image quality. This research investigates practitioner comp... Read More about A 6 year study of mammographic compression force : practitioner variability within and between screening sites.

An audit to investigate the impact of false positive breast screening results and diagnostic work-up on re-engagement with subsequent routine screening (2014)
Journal Article
Nightingale, J., Borgen, R., Porter-Bennett, L., & Szczepura, K. (2014). An audit to investigate the impact of false positive breast screening results and diagnostic work-up on re-engagement with subsequent routine screening. Radiography, 21(1), 7-10. https://doi.org/10.1016/j.radi.2014.05.005

Introduction: Women attending breast screening may have suspicious mammographic findings that are subsequently found at assessment clinic to be normal (false positive, FP). A false positive diagnosis is not harmless, with short and long term negativ... Read More about An audit to investigate the impact of false positive breast screening results and diagnostic work-up on re-engagement with subsequent routine screening.

An overview of measuring and modelling dose and risk from ionising radiation for medical exposures (2014)
Journal Article
risk from ionising radiation for medical exposures. Radiography, 20(4), 323-332. https://doi.org/10.1016/j.radi.2014.05.002

PURPOSE: This paper gives an overview of the methods that are used to calculate dose and risk from exposure to ionizing radiation as a support to other papers in this special issue. BACKGROUND: The optimization of radiation dose is a legal requir... Read More about An overview of measuring and modelling dose and risk from ionising radiation for medical exposures.

Breast tissue bulge and lesion visibility during stereotactic biopsy – a phantom study (2014)
Journal Article
Williams, S., Hackney, L., Hogg, P., & Szczepura, K. (2014). Breast tissue bulge and lesion visibility during stereotactic biopsy – a phantom study. Radiography, 20(3), 271-276. https://doi.org/10.1016/j.radi.2014.04.006

Background During mammography guided stereotactic breast biopsy a bulge of tissue can form in the paddle needle biopsy aperture. This bulge has been estimated to have a height of up to 30% of the breast itself. During clinical biopsy we have noti... Read More about Breast tissue bulge and lesion visibility during stereotactic biopsy – a phantom study.

A free-response evaluation determining value in the computed tomography attenuation correction image for revealing pulmonary incidental findings : a phantom study (2014)
Journal Article
Thompson, J., Hogg, P., Manning, D., Szczepura, K., & Chakraborty, D. (2014). A free-response evaluation determining value in the computed tomography attenuation correction image for revealing pulmonary incidental findings : a phantom study. Academic radiology, 21(4), 538-545. https://doi.org/10.1016/j.acra.2014.01.003

RATIONALE AND OBJECTIVES: The purpose of this study was to compare lesion-detection performance when interpreting computed tomography (CT) images that are acquired for attenuation correction when performing single photon emission computed tomography/... Read More about A free-response evaluation determining value in the computed tomography attenuation correction image for revealing pulmonary incidental findings : a phantom study.

Radionuclide Metabolic Therapy (2013)
Book
S. Mantel, E., Williams, J., Szczepura, K., Sjögreen Gleisner, K., Strigari, L., Flux, G., …S. Cutler, C. (2013). C. Peştean, V. Veloso Jerónimo, & P. Hogg (Eds.), Radionuclide Metabolic Therapy. European Association of Nuclear Medicine. https://doi.org/10.52717/YFWJ5262

Fact or fiction : an analysis of the 10 kVp ‘rule’ in computed radiography (2013)
Journal Article
radiography. Radiography, 19(3), 223-227. https://doi.org/10.1016/j.radi.2013.05.003

Purpose: To determine whether increasing the tube voltage by 10 kVp whilst reducing the tube current by 50% (10 kVp ‘rule’) produces similar perceptual image quality. Method: 391 matched pairs of anthropomorphic chest phantom X-ray images were pro... Read More about Fact or fiction : an analysis of the 10 kVp ‘rule’ in computed radiography.

Tissue bulge during stereotactic core biopsy (2013)
Journal Article
Hackney, L., Williams, S., Hogg, P., & Szczepura, K. (2013). Tissue bulge during stereotactic core biopsy. Radiography, 19(4), 366-368. https://doi.org/10.1016/j.radi.2013.06.007

In full field digital mammography (FFDM) the whole breast is subjected to compression with a perspex compression paddle in order to reduce breast thickness and improve image quality. Once a mammographic abnormality has been detected using FFDM and a... Read More about Tissue bulge during stereotactic core biopsy.

Practitioner compression force variation in mammography : a 6 year study (2013)
Journal Article
Mercer, C., Hogg, P., Szczepura, K., & Denton, E. (2013). Practitioner compression force variation in mammography : a 6 year study. Radiography, 19(3), 200-206. https://doi.org/10.1016/j.radi.2013.06.001

The application of breast compression in mammography may be more heavily influenced by the practitioner rather than the client. This could affect image quality and will affect client experience. This study builds on previous research to establish i... Read More about Practitioner compression force variation in mammography : a 6 year study.

A method to measure paddle and detector pressures and footprints in mammography (2013)
Journal Article
Hogg, P., Szczepura, K., Darlington, A., & Maxwell, A. (2013). A method to measure paddle and detector pressures and footprints in mammography. Medical Physics, 40(4), 041907. https://doi.org/10.1118/1.4792720

Purpose: Compression is necessary in mammography to improve image quality and reduce radiation burden. Maximizing the amount of breast in contact with the image receptor (IR) is important. To achieve this, for the craniocaudal projection, there is n... Read More about A method to measure paddle and detector pressures and footprints in mammography.

Optimising the number of thermoluminescent dosimeters required for the measurement of effective dose for computed tomography attenuation correction data in SPECT/CT myocardial perfusion imaging (2013)
Journal Article
Tootell, A., Szczepura, K., & Hogg, P. (2013). Optimising the number of thermoluminescent dosimeters required for the measurement of effective dose for computed tomography attenuation correction data in SPECT/CT myocardial perfusion imaging. Radiography, 19(1), 42-47. https://doi.org/10.1016/j.radi.2012.11.001

Background The use of thermoluminescent dosimeters (TLDs) is regarded as time consuming and laborious. As part of our dosimetry research it was necessary to optimise the use of our resources, both physical and time. Experimental work was carried... Read More about Optimising the number of thermoluminescent dosimeters required for the measurement of effective dose for computed tomography attenuation correction data in SPECT/CT myocardial perfusion imaging.

Pressure and breast thickness in mammography : an exploratory calibration study (2013)
Journal Article
Hogg, P., Taylor, M., Szczepura, K., Mercer, C., & Denton, E. (2013). Pressure and breast thickness in mammography : an exploratory calibration study. British Journal of Radiology, 86(1021), 1-7. https://doi.org/10.1259/bjr.20120222

Objective To perform a calibration study to provide data to help improve consistency in the pressure that is applied during mammography. Methods Automatic readouts of breast thickness accuracy vary between mammography machines; therefore, one m... Read More about Pressure and breast thickness in mammography : an exploratory calibration study.

Analysis of CT acquisition parameters suitable for use in SPECT/CT : a free-response receiver operating characteristic study (2012)
Journal Article
Thompson, J., Hogg, P., Szczepura, K., & Manning, D. (2012). Analysis of CT acquisition parameters suitable for use in SPECT/CT : a free-response receiver operating characteristic study. Radiography, 18(4), 238-243. https://doi.org/10.1016/j.radi.2012.05.004

Purpose This dose optimisation free-response receiver operating characteristic (FROC) study compares the diagnostic performance of 8 CT acquisition parameter settings suitable for use with diagnostic quality SPECT/CT systems. Observers were requi... Read More about Analysis of CT acquisition parameters suitable for use in SPECT/CT : a free-response receiver operating characteristic study.

ROCView : prototype software for data collection in jackknife alternative free-response receiver operating characteristic analysis (2012)
Journal Article
Thompson, J., Hogg, P., Thompson, S., Manning, D., & Szczepura, K. (2012). ROCView : prototype software for data collection in jackknife alternative free-response receiver operating characteristic analysis. British Journal of Radiology, 85, 1320-1326. https://doi.org/10.1259/bjr/99497945

ROCView has been developed as an image display and response capture (IDRC) solution to image display and consistent recording of reader responses in relation to the free-response receiver operating characteristic paradigm. A web-based solution to IDR... Read More about ROCView : prototype software for data collection in jackknife alternative free-response receiver operating characteristic analysis.

The readout thickness versus the measured thickness for a range of screen film mammography (SFM) and full-field digital mammography (FFDM) units (2011)
Journal Article
Hauge, I., Hogg, P., Szczepura, K., Connolly, P., McGill, G., & Mercer, C. (2011). The readout thickness versus the measured thickness for a range of screen film mammography (SFM) and full-field digital mammography (FFDM) units. Medical Physics, 39(1), 263-271. https://doi.org/10.1118/1.3663579

PURPOSE: To establish a simple method to determine breast readout accuracy on mammography units. METHODS: A thickness measuring device (TMD) was used in conjunction with a breast phantom. This phantom had compression characteristics similar to human... Read More about The readout thickness versus the measured thickness for a range of screen film mammography (SFM) and full-field digital mammography (FFDM) units.

Analysis of plain X-ray and low resolution CT gonad dose arising from supplementary imaging after bone scanning (2011)
Journal Article
Kelly, J., Szczepura, K., Hogg, P., & Tootell, A. (2011). Analysis of plain X-ray and low resolution CT gonad dose arising from supplementary imaging after bone scanning. European Journal of Nuclear Medicine and Molecular Imaging, 38(Sup. 2), S445. https://doi.org/10.1007/s00259-011-1913-y

Introduction:Bone scintigraphy has long been the first stop for patients undergoing investigation of bone metastases. The procedure is recognised as being highly sensitive to the disease however this corresponds to a low specificity. As a result s... Read More about Analysis of plain X-ray and low resolution CT gonad dose arising from supplementary imaging after bone scanning.

Prototype software for the clinical evaluation of In-111 SPECT-CT dotatate images conducted prior to and immediately after Y-90 dotatate radionuclide therapy (2011)
Journal Article
Hogg, P., Swire, V., Orlinksi, M., Blindell, P., Vinjamuri, S., & Szczepura, K. (2011). Prototype software for the clinical evaluation of In-111 SPECT-CT dotatate images conducted prior to and immediately after Y-90 dotatate radionuclide therapy. European Journal of Nuclear Medicine and Molecular Imaging, 38(Sup. 2), S447. https://doi.org/10.1007/s00259-011-1913-y

Aim and Background Neuroendocrine tumours (NETs) are heterogenous and frequently express cell membrane specific peptide receptors such as somatostatin receptors (SSTRs). Radiolabelled receptor binding of somatostatin analogues can guide radioact... Read More about Prototype software for the clinical evaluation of In-111 SPECT-CT dotatate images conducted prior to and immediately after Y-90 dotatate radionuclide therapy.

Measuring whole-body neutrophil redistribution using a dedicated whole-body counter and ultra-low doses of 111 Indium (2011)
Journal Article
Szczepura, K., Ruparelia, P., Solanki, C., Balan, K., Newbold, P., Summers, C., …Peters, A. (2011). Measuring whole-body neutrophil redistribution using a dedicated whole-body counter and ultra-low doses of 111 Indium. European Journal of Clinical Investigation, 41(1), 77-83. https://doi.org/10.1111/j.1365-2362.2010.02382.x

Background - There is increasing interest in the ‘homing’ of neutrophils to bone marrow. The aim of this study was to measure the whole-body redistribution of 111In using a whole-body counter following the administration of ultra-small activities of... Read More about Measuring whole-body neutrophil redistribution using a dedicated whole-body counter and ultra-low doses of 111 Indium.

Quantification of neutrophil migration into the lungs of patients with chronic obstructive pulmonary disease (2011)
Journal Article
Ruparelia, P., Szczepura, K., Summers, C., Solanki, C., Balan, K., Newbold, P., …Chilvers, E. (2011). Quantification of neutrophil migration into the lungs of patients with chronic obstructive pulmonary disease. European Journal of Nuclear Medicine and Molecular Imaging, 38(5), 911-919. https://doi.org/10.1007/s00259-010-1715-7

Objective: to quantify neutrophil migration into the lungs of patients with chronic pulmonary obstructive disease (COPD). Methods: neutrophil loss via airways was assessed by dedicated whole-body counting 45 min, 24 h and 2, 4, 7 and 10 days after... Read More about Quantification of neutrophil migration into the lungs of patients with chronic obstructive pulmonary disease.

Determination of optimal CT exposure factors for lung lesions using an anthropomorphic chest phantom for SPECT-CT (2010)
Journal Article
Thompson, J., Szczepura, K., Tootell, A., Sil, J., Manning, D., & Hogg, P. (2010). Determination of optimal CT exposure factors for lung lesions using an anthropomorphic chest phantom for SPECT-CT. European Journal of Nuclear Medicine and Molecular Imaging, 37(Sup. 2), S494. https://doi.org/10.1007/s00259-010-1560-8

PURPOSE: SPECT‐CT is a valuable modality for diagnosis and staging of primary and secondary malignant disease and also diagnosing benign conditions. CT incurs a significant radiation burden; consequently CT acquisition parameters require optimisati... Read More about Determination of optimal CT exposure factors for lung lesions using an anthropomorphic chest phantom for SPECT-CT.

Does P-glycoprotein have a role in the lung clearances of inhaled 99m Tc-sestamibi and 99m Tc-tetrofosmin? (2009)
Journal Article
Cheow, H., Ruparelia, P., Shankar, S., Szczepura, K., Ballinger, J., Hartman, N., …Peters, A. (2009). Does P-glycoprotein have a role in the lung clearances of inhaled 99m Tc-sestamibi and 99m Tc-tetrofosmin?. Nuclear Medicine Communications, 30(8), 617-621. https://doi.org/10.1097/MNM.0b013e32832b9a2d

Objective - The clearance rate of inhaled 99mTc-sestamibi from the lungs of healthy nonsmoking individuals is much slower than would be expected from its physical properties. The clearance rate is even slower in healthy cigarette smokers. As 99mTc-s... Read More about Does P-glycoprotein have a role in the lung clearances of inhaled 99m Tc-sestamibi and 99m Tc-tetrofosmin?.

Does P-glycoprotein have a role in the lung clearances of inhaled 99mTc-sestamibi and 99mTc-tetrofosmin? (2009)
Journal Article
Cheow, H., Ruparelia, P., Shankar, S., Szczepura, K., Ballinger, J., Hartman, N., …Michael Peters, A. (2009). Does P-glycoprotein have a role in the lung clearances of inhaled 99mTc-sestamibi and 99mTc-tetrofosmin?. Nuclear Medicine Communications, 30(8), 617-621. https://doi.org/10.1097/mnm.0b013e32832b9a2d

Objective The clearance rate of inhaled 99mTc-sestamibi from the lungs of healthy nonsmoking individuals is much slower than would be expected from its physical properties. The clearance rate is even slower in healthy cigarette smokers. As 99mTc-se... Read More about Does P-glycoprotein have a role in the lung clearances of inhaled 99mTc-sestamibi and 99mTc-tetrofosmin?.

Pulmonary elimination rate of inhaled 99m Tc-sestamibi radioaerosol is delayed in healthy cigarette smokers (2008)
Journal Article
Ruparelia, P., Cheow, H., Evans, J., Banney, L., Shankar, S., Szczepura, K., …Peters, A. (2008). Pulmonary elimination rate of inhaled 99m Tc-sestamibi radioaerosol is delayed in healthy cigarette smokers. British Journal of Clinical Pharmacology, 65(4), 611-614. https://doi.org/10.1111/j.1365-2125.2008.03099.x

Aim - To explore inhaled technetium-99m-labelled hexakis-methoxy-isobutyl isonitrile (99mTc-sestamibi) for quantifying pulmonary P-glycoprotein(P-gp) expression. Methods - The elimination rate from the lungs of 99mTc-sestamibi was recorded scintigra... Read More about Pulmonary elimination rate of inhaled 99m Tc-sestamibi radioaerosol is delayed in healthy cigarette smokers.

Healthy passive cigarette smokers have increased pulmonary alveolar permeability (2007)
Journal Article
Beadsmoore, C., Cheow, H., Szczepura, K., Ruparelia, P., & Michael Peters, A. (2007). Healthy passive cigarette smokers have increased pulmonary alveolar permeability. Nuclear Medicine Communications, 28(2), 75-77. https://doi.org/10.1097/MNM.0b013e328013eb1e

Question Does passive smoking have a measurable effect on lung function in otherwise healthy subjects? There is current interest concerning passive smoking but no objective evidence showing that it has any impact on lung function. Methods The... Read More about Healthy passive cigarette smokers have increased pulmonary alveolar permeability.

P16 Healthy passive cigarette smokers have increased pulmonary alveolar permeability (2006)
Journal Article
Beadsmoore, C., Cheow, H., Szczepura, K., Ruparelia, P., & Peters, A. (2006). P16 Healthy passive cigarette smokers have increased pulmonary alveolar permeability. Nuclear Medicine Communications, 27(12), 1027-1028. https://doi.org/10.1097/00006231-200612000-00067

Background and aim To determine whether passive smoking has a measurable effect on lung function in otherwise healthy subjects? There is current interest concerning passive smoking but no objective evidence showing that it has any impact on lung func... Read More about P16 Healthy passive cigarette smokers have increased pulmonary alveolar permeability.

Granulocyte trafficking in chronic obstructive pulmonary disease (2006)
Journal Article
Ruparelia, P., Szczepura, K., Bilton, D., Peters, A., & Chilvers, E. (2006). Granulocyte trafficking in chronic obstructive pulmonary disease. Thorax, 61(Sup. 2), ii108-ii109

Introduction: Chronic obstructive pulmonary disease (COPD) is an inflammatory condition of the airways characterised by intense neutrophilia. We have used sub-imaging doses of 111 indium (111In) labelled granulocytes and high sensitivity whole body c... Read More about Granulocyte trafficking in chronic obstructive pulmonary disease.

A16 Using whole-body counting to determine neutrophil trafficking and loss in COPD (2006)
Journal Article
Szczepura, K., Ruparelia, P., Bilton, D., Chilvers, E., & Peters, A. (2006). A16 Using whole-body counting to determine neutrophil trafficking and loss in COPD. Nuclear Medicine Communications, 27(3), 285. https://doi.org/10.1097/00006231-200603000-00027

COPD is an inflammatory condition of the airways characterized by airway neutrophilia. Using a whole-body-counter (WBC) we have assessed neutrophil trafficking and loss in COPD using small activities of 111In-labelled neutrophils. Patients were scann... Read More about A16 Using whole-body counting to determine neutrophil trafficking and loss in COPD.

Quantification of disease activity in patients undergoing leucocyte scintigraphy for suspected inflammatory bowel disease (2004)
Journal Article
Cheow, H., Voutnis, D., Evans, J., Szczepura, K., Swift, E., Bird, N., …Peters, A. (2005). Quantification of disease activity in patients undergoing leucocyte scintigraphy for suspected inflammatory bowel disease. European Journal of Nuclear Medicine and Molecular Imaging, 32(3), 329-337. https://doi.org/10.1007/s00259-004-1617-7

Purpose Whole-body gamma camera counting is an alternative to faecal 111In collection for quantifying disease activity in inflammatory bowel disease (IBD) but requires administration of imaging activities of 111In. The aim of this study was to explo... Read More about Quantification of disease activity in patients undergoing leucocyte scintigraphy for suspected inflammatory bowel disease.

P25. Tolerance and diagnostic accuracy of myocardial scintigraphy with adenosine infusion, 6 min (standard) versus 3 min (abbreviated) protocol (2003)
Journal Article
Gopinath, G., Buscombe, J., Naojee, S., Szczepura, K., & Hilson, A. (2003). P25. Tolerance and diagnostic accuracy of myocardial scintigraphy with adenosine infusion, 6 min (standard) versus 3 min (abbreviated) protocol. Nuclear Medicine Communications, 24(4), 476. https://doi.org/10.1097/00006231-200304000-00114

Myocardial perfusion scintigraphy with adenosine is an effective and safe method for diagnosing coronary artery disease (CAD). Various reports suggest that a 3 min stress regime is as efficacious as a 6 min regime. The aim of the study was to study t... Read More about P25. Tolerance and diagnostic accuracy of myocardial scintigraphy with adenosine infusion, 6 min (standard) versus 3 min (abbreviated) protocol.