Prof Marija Krstic-Demonacos' Outputs (38)

Modelling and analysis of glucocorticoid action in childhood acute lymphoblastic leukaemia (2025)
Thesis

Acute lymphoblastic leukaemia (ALL) is characterised by the abnormal proliferation of white
blood cells. Glucocorticoids (GCs) induce apoptosis in leukaemia through the glucocorticoid
receptor (GR) and are the main treatment for ALL. The obstacle t... Read More about Modelling and analysis of glucocorticoid action in childhood acute lymphoblastic leukaemia.

Analysis of the Role of Immune System and Microenvironment in Leukaemia (2025)
Thesis

The immune system and microenvironment have been implicated in chemotherapy resistance
in acute lymphoblastic leukaemia (ALL). Despite the development of different therapies, the
detailed mechanism underlying chemotherapy resistance is not well und... Read More about Analysis of the Role of Immune System and Microenvironment in Leukaemia.

Investigation of P53 and TTC5 function in lung cancer (2024)
Thesis

Lung cancer represents 11.6% of the total cases with patients destined for a poor outcome due to late-stage detection, therefore it is important to find new approaches to detect and treat this disease. Current evidence suggests a role of p53 gene and... Read More about Investigation of P53 and TTC5 function in lung cancer.

Targeting Transcriptional CDKs in Medulloblastoma (2024)
Thesis

Medulloblastoma (MB) is the most common malignant tumour of the brain in children. Current treatments include surgery, radiotherapy and chemotherapy. Although the five-year survival rate is over 70%, the treatment is exceptionally aggressive, leaving... Read More about Targeting Transcriptional CDKs in Medulloblastoma.

Evaluation of Novel Diketones as Anti-cancer Agents (2024)
Thesis

Recent studies indicated high levels of cytotoxicity of dibenzoylmethane (DBM) and its derivatives on some mammalian cancer cells. On the other hand, p53 tumour suppressor is a DNA damage inducible transcription factor mutated in over half of human c... Read More about Evaluation of Novel Diketones as Anti-cancer Agents.

Intratumor microbiota as a novel potential prognostic indicator in mesothelioma (2023)
Journal Article
Pentimalli, F., Krstic- Demonacos, M., Costa, C., Mutti, L., & Bakker, E. (2023). Intratumor microbiota as a novel potential prognostic indicator in mesothelioma. Frontiers in Immunology, 14, https://doi.org/10.3389/fimmu.2023.1129513

Introduction: Despite increased attention on immunotherapy, primarily immune checkpoint blockade, as a therapeutic approach for mesothelioma (MMe), its efficacy and tolerability remain questioned. One potential explanation for different responses to... Read More about Intratumor microbiota as a novel potential prognostic indicator in mesothelioma.

Elimination of Off-Target Effect by Chemical Modification of 5'-End of Small Interfering RNA (2022)
Journal Article

In this study, the efficiency of RNA interference of small interfering RNAs (siRNAs) bearing 5′-O-methyl-2′-deoxythymidine (X) and 5′-amino-2′, 5′-dideoxythymidine (Z) at the 5′-end of the sense strand and the antisense strand of siRNA was investigat... Read More about Elimination of Off-Target Effect by Chemical Modification of 5'-End of Small Interfering RNA.

Comparison of 3 randomized clinical trials of frontline therapies for malignant pleural mesothelioma (2022)
Journal Article

Importance: Some recently proposed frontline therapies for malignant pleural mesothelioma (MPM) are very costly, yet their impact on quality of life and overall survival of these patients remains arguable. Given the high social toll of this aggressiv... Read More about Comparison of 3 randomized clinical trials of frontline therapies for malignant pleural mesothelioma.

Protein disulfide isomerase A1‑associated pathways in the development of stratified breast cancer therapies (2022)
Journal Article
Bakker, E., Fujii, M., Krstic‑Demonacos, M., Demonacos, C., & Alhammad, R. (2022). Protein disulfide isomerase A1‑associated pathways in the development of stratified breast cancer therapies. International Journal of Oncology, 60(2), 16. https://doi.org/10.3892/ijo.2022.5306

The oxidoreductase protein disulfide isomerase A1 (PDIA1) functions as a cofactor for many transcription factors including estrogen receptor α (ERα), nuclear factor (NF)‑κB, nuclear factor erythroid 2‑like 2 (NRF2) and regulates the protein stability... Read More about Protein disulfide isomerase A1‑associated pathways in the development of stratified breast cancer therapies.

Evaluation of the role of p53 tumour suppressor posttranslational modifications and TTC5 cofactor in lung cancer (2021)
Journal Article

Mutations in the p53 tumor suppressor are found in over 50% of cancers. p53 function is controlled through posttranslational modifications and cofactor interactions. In this study, we investigated the posttranslationally modified p53, including p53 a... Read More about Evaluation of the role of p53 tumour suppressor posttranslational modifications and TTC5 cofactor in lung cancer.

Is there already a need of reckoning on cancer immunotherapy? (2021)
Journal Article
Correale, P., Pentimalli, F., Baglio, G., Krstic- Demonacos, M., Saladino, R., Giordano, A., & Mutti, L. (2021). Is there already a need of reckoning on cancer immunotherapy?. Frontiers in Pharmacology, 12, 638279. https://doi.org/10.3389/fphar.2021.638279

Circular and linear : a tale of aptamer selection for the activation of SIRT1 to induce death in cancer cells (2020)
Journal Article
Al-Sudani, B., Ragazzon-Smith, A., Aziz, A., Alansari, R., Ferry, N., Krstic- Demonacos, M., & Ragazzon, P. (2020). Circular and linear : a tale of aptamer selection for the activation of SIRT1 to induce death in cancer cells. RSC Advances, 10(73), 45008-45018. https://doi.org/10.1039/D0RA07857C

It is a challenge to select the right target to treat conditions without affecting non-diseased cells. Cancer belongs to the top 10 causes of death in the world and it remains difficult to treat. Amongst cancer emerging targets, silent information re... Read More about Circular and linear : a tale of aptamer selection for the activation of SIRT1 to induce death in cancer cells.

Marija Krstic-Demonacos, Professor of Molecular Medicine (2020)
Data

An insight into the research of Prof Marija Krstic-Demonacos, Director of the Biomedical Research Centre at the University of Salford as part of the Festival of Research in July 2018.

Protein disulfide isomerase A1 regulates breast cancer cell immunorecognition in a manner dependent on redox state (2020)
Journal Article

Oxidoreductase protein disulphide isomerases (PDI) are involved in the regulation of a variety of biological processes including the modulation of endoplasmic reticulum (ER) stress, unfolded protein response (UPR), ER‑mitochondria communication and t... Read More about Protein disulfide isomerase A1 regulates breast cancer cell immunorecognition in a manner dependent on redox state.

Endoplasmic reticulum stress, unfolded protein response and autophagy contribute to resistance to glucocorticoid treatment in human acute lymphoblastic leukaemia cells (2020)
Journal Article

Acute lymphoblastic leukaemia (ALL) is the most frequent childhood cancer and, although it is highly treatable, resistance to therapy, toxicity and side effects remain challenging. The synthetic glucocorticoid (GC) dexamethasone (Dex) is commonly use... Read More about Endoplasmic reticulum stress, unfolded protein response and autophagy contribute to resistance to glucocorticoid treatment in human acute lymphoblastic leukaemia cells.

Telomerase inhibition, Telomere attrition and proliferation arrest of cancer cells induced by Phosphorothioate ASO-NLS conjugates targeting hTERC and siRNAs targeting hTERT (2020)
Journal Article
Diala, I., Shiohama, Y., Fujita, T., Demonacos, C., Krstic- Demonacos, M., Di Leva, G., & Fujii, N. (2020). Telomerase inhibition, Telomere attrition and proliferation arrest of cancer cells induced by Phosphorothioate ASO-NLS conjugates targeting hTERC and siRNAs targeting hTERT. Nucleosides, Nucleotides and Nucleic Acids, 39(1-3), 407-425. https://doi.org/10.1080/15257770.2020.1713357

Telomerase activity has been regarded as a critical step in cellular immortalization and carcinogenesis and because of this, regulation of telomerase represents an attractive target for anti-tumor specific therapeutics. Recently, one avenue of cancer... Read More about Telomerase inhibition, Telomere attrition and proliferation arrest of cancer cells induced by Phosphorothioate ASO-NLS conjugates targeting hTERC and siRNAs targeting hTERT.

Sirtuin family members selectively regulate autophagy in osteosarcoma and mesothelioma cells in response to cellular stress (2019)
Journal Article

The class III NAD+ dependent deacetylases-sirtuins (SIRTs) link transcriptional regulation to DNA damage response and reactive oxygen species generation thereby modulating a wide range of cellular signalling pathways. Here the contribution of SIRT1,... Read More about Sirtuin family members selectively regulate autophagy in osteosarcoma and mesothelioma cells in response to cellular stress.

What can independent research for Mesothelioma achieve to treat this orphan disease? (2019)
Journal Article
Guazzelli, A., Meysami, P., Bakker, E., Bonanni, E., Demonacos, C., Krstic- Demonacos, M., & Mutti, L. (2019). What can independent research for Mesothelioma achieve to treat this orphan disease?. Expert Opinion on Investigational Drugs, 28(8), 719-732. https://doi.org/10.1080/13543784.2019.1638363

Introduction: Malignant pleural mesothelioma (MPM) is a rare neoplasm with a poor prognosis, as current therapies are ineffective. Despite the increased understanding of the molecular biology of mesothelioma, there is still a lack of drugs that drama... Read More about What can independent research for Mesothelioma achieve to treat this orphan disease?.

BAP1 status determines the sensitivity of malignant mesothelioma cells to gemcitabine treatment (2019)
Journal Article

Malignant mesothelioma (MMe) is a cancer with poor prognosis and resistance to standard treatments. Recent reports have highlighted the role of the BRCA associated protein 1 gene BAP1 in the development of MMe. In this study, the chemosensitivity of... Read More about BAP1 status determines the sensitivity of malignant mesothelioma cells to gemcitabine treatment.

p53 modeling as a route to mesothelioma patients' stratification and novel therapeutic identification (2018)
Journal Article

Background: Malignant pleural mesothelioma (MPM) is an orphan disease that is difficult to treat using traditional chemotherapy, an approach which has been effective in other types of cancer. Most chemotherapeutics cause DNA damage leading to cell de... Read More about p53 modeling as a route to mesothelioma patients' stratification and novel therapeutic identification.