Circular and linear : a tale of aptamer selection for the activation of SIRT1 to induce death in cancer cells (2020)
Journal Article
Al-Sudani, B., Ragazzon-Smith, A., Aziz, A., Alansari, R., Ferry, N., Krstic- Demonacos, M., & Ragazzon, P. (2020). Circular and linear : a tale of aptamer selection for the activation of SIRT1 to induce death in cancer cells. RSC Advances, 10(73), 45008-45018. https://doi.org/10.1039/D0RA07857C

It is a challenge to select the right target to treat conditions without affecting non-diseased cells. Cancer belongs to the top 10 causes of death in the world and it remains difficult to treat. Amongst cancer emerging targets, silent information re... Read More about Circular and linear : a tale of aptamer selection for the activation of SIRT1 to induce death in cancer cells.

Living with Coronavirus (COVID-19) : a brief report (2020)
Journal Article
Khurshid, A., Ahmed, M., Aziz, A., & Amin, R. (2020). Living with Coronavirus (COVID-19) : a brief report. European review for medical and pharmacological sciences (Online), 24(20), 10902-10912. https://doi.org/10.26355/eurrev_202010_23455

The world will never be same after the current COVID-19 pandemic. We may have to live with the coronavirus for a long time. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has resulted in a major burden on the global health... Read More about Living with Coronavirus (COVID-19) : a brief report.

Dibenzoyl-methane derivatives as potential and exciting new therapy for the treatment of childhood bone cancer (2016)
Journal Article
Almelah, E., Smith, D., McGown, A., Aziz, A., Potgieter, H., & Ragazzon, P. (2016). Dibenzoyl-methane derivatives as potential and exciting new therapy for the treatment of childhood bone cancer. Anticancer Research, 36(11), 6043-6050. https://doi.org/10.21873/anticanres.11193

Abstract. Childhood bone cancer though rare, has very limited treatment choices, with poor survival rates and often involving amputation. We have developed a novel molecule, 2', 4'-dihydroxy-dithion-dibenzoyl-methane and tested it on hepatic, colon,... Read More about Dibenzoyl-methane derivatives as potential and exciting new therapy for the treatment of childhood bone cancer.

JAK2V617F homozygosity drives a phenotypic switch in myeloproliferative neoplasms, but is insufficient to sustain disease (2014)
Journal Article
Li, J., Kent, D., Godfrey, A., Manning, H., Nangalia, J., Aziz, A., …Green, A. (2014). JAK2V617F homozygosity drives a phenotypic switch in myeloproliferative neoplasms, but is insufficient to sustain disease. Blood, 123(20), 3139-3151. https://doi.org/10.1182/blood-2013-06-510222

Genomic regions of acquired uniparental disomy (UPD) are common in malignancy and frequently harbor mutated oncogenes. Homozygosity for such gain-of-function mutations is thought to modulate tumor phenotype, but direct evidence has been elusive. Poly... Read More about JAK2V617F homozygosity drives a phenotypic switch in myeloproliferative neoplasms, but is insufficient to sustain disease.

Somatic CALR Mutations in myeloproliferative neoplasms with nonmutated JAK2 (2013)
Journal Article
Nangalia, J., Massie, C., Baxter, E., Nice, F., Gundem, G., Wedge, D., …Aziz, A. E. A. (2013). Somatic CALR Mutations in myeloproliferative neoplasms with nonmutated JAK2. New England Journal of Medicine, 369(25), 2391-2405. https://doi.org/10.1056/NEJMoa1312542

BACKGROUND:
Somatic mutations in the Janus kinase 2 gene (JAK2) occur in many myeloproliferative neoplasms, but the molecular pathogenesis of myeloproliferative neoplasms with nonmutated JAK2 is obscure, and the diagnosis of these neoplasms remains... Read More about Somatic CALR Mutations in myeloproliferative neoplasms with nonmutated JAK2.

MafB restricts M-CSF-Dependent myeloid commitment divisions of hematopoietic stem cells (2009)
Journal Article
Sarrazin, S., Mossadegh-Keller, N., Fukao, T., Aziz, A., Mourcin, F., Vanhille, L., …Sieweke, M. (2009). MafB restricts M-CSF-Dependent myeloid commitment divisions of hematopoietic stem cells. Cell, 138(2), 300-313. https://doi.org/10.1016/j.cell.2009.04.057

While hematopoietic stem cell (HSC) self-renewal is well studied, it remains unknown whether distinct control mechanisms enable HSC divisions that generate progeny cells with specific lineage bias. Here, we report that the monocytic transcription fac... Read More about MafB restricts M-CSF-Dependent myeloid commitment divisions of hematopoietic stem cells.

MafB/c-Maf deficiency enables self-renewal of differentiated functional macrophages (2009)
Journal Article
Aziz, A., Soucie, E., Sarrazin, S., & Sieweke, M. (2009). MafB/c-Maf deficiency enables self-renewal of differentiated functional macrophages. Science, 326(5954), 867-871. https://doi.org/10.1126/science.1176056

In metazoan organisms, terminal differentiation is generally tightly linked to cell cycle exit, whereas the undifferentiated state of pluripotent stem cells is associated with unlimited self-renewal. Here, we report that combined deficiency for the t... Read More about MafB/c-Maf deficiency enables self-renewal of differentiated functional macrophages.

New molecular and cellular aspects of mutant calreticulin in Myeloproliferative Neoplasms
Thesis
Morlan-mairal, M. (in press). New molecular and cellular aspects of mutant calreticulin in Myeloproliferative Neoplasms. (Thesis). University of Salford

Calreticulin (CALR) is an endoplasmic reticulum (ER) protein that plays an important role as a calcium (Ca2+) buffering chaperone. Mutations in CALR exon 9 have been identified in essential thrombocythemia and primary myelofibrosis, two myeloprolifer... Read More about New molecular and cellular aspects of mutant calreticulin in Myeloproliferative Neoplasms.