Restoring perivascular adipose tissue function in obesity using exercise (2021)
Journal Article
Saxton, S., Toms, L., Aldous, R., Withers, S., Ohanian, J., & Heagerty, A. (2021). Restoring perivascular adipose tissue function in obesity using exercise. Cardiovascular Drugs and Therapy, 35(6), 1291-1304. https://doi.org/10.1007/s10557-020-07136-0

Perivascular adipose tissue (PVAT) exerts an anti-contractile effect which is vital in regulating vascular tone. This effect is mediated via sympathetic nervous stimulation of PVAT by a mechanism which involves noradrenaline uptake through organic ca... Read More about Restoring perivascular adipose tissue function in obesity using exercise.

Interleukin-33 rescues perivascular adipose tissue anticontractile function in obesity (2020)
Journal Article
Saxton, S., Whitley, A., Potter, R., Withers, S., Grencis, R., & Heagerty, A. (2020). Interleukin-33 rescues perivascular adipose tissue anticontractile function in obesity. American journal of physiology. Heart and circulatory physiology, 319(6), H1387-H1397. https://doi.org/10.1152/ajpheart.00491.2020

Perivascular adipose tissue (PVAT) depots are metabolically active and play a major vasodilator role in healthy lean individuals. In obesity, they become inflamed and eosinophil-depleted and the anticontractile function is lost with the development o... Read More about Interleukin-33 rescues perivascular adipose tissue anticontractile function in obesity.

MiRNAs as novel adipokines : obesity-related circulating MiRNAs influence chemosensitivity in cancer patients (2020)
Journal Article
Withers, S., Dewhurst, T., Hammond, C., & Topham, C. (2020). MiRNAs as novel adipokines : obesity-related circulating MiRNAs influence chemosensitivity in cancer patients. Non-Coding RNA, 6(1), e5. https://doi.org/10.3390/ncrna6010005

Adipose tissue is an endocrine organ, capable of regulating distant physiological processes in other tissues via the release of adipokines into the bloodstream. Recently, circulating adipose-derived microRNAs (miRNAs) have been proposed as a novel cl... Read More about MiRNAs as novel adipokines : obesity-related circulating MiRNAs influence chemosensitivity in cancer patients.

β3-adrenoceptor stimulation of perivascular adipocytes leads to increased fat cell-derived nitric oxide and vascular relaxation in small arteries (2018)
Journal Article
Bussey, C., Withers, S., Saxton, S., Bodagh, N., Aldous, R., & Heagerty, A. (2018). β3-adrenoceptor stimulation of perivascular adipocytes leads to increased fat cell-derived nitric oxide and vascular relaxation in small arteries. British Journal of Pharmacology, 175(18), 2685-3698. https://doi.org/10.1111/bph.14433

BACKGROUND AND PURPOSE In response to norepinephrine healthy perivascular adipose tissue (PVAT) exerts an anticontractile effect on adjacent small arterial tissue. Organ bath solution transfer experiments have demonstrated the release of PVAT-deriv... Read More about β3-adrenoceptor stimulation of perivascular adipocytes leads to increased fat cell-derived nitric oxide and vascular relaxation in small arteries.

Modulation of vascular reactivity by perivascular adipose tissue (PVAT) (2018)
Journal Article
Agabiti Rosei, C., Paini, A., De Ciuceis, C., Withers, S., Greenstein, A., Heagerty, A., & Rizzoni, D. (2018). Modulation of vascular reactivity by perivascular adipose tissue (PVAT). Current Hypertension Reports, 20(44), https://doi.org/10.1007/s11906-018-0835-5

Purpose of Review: In this review we discuss the role of perivascular adipose tissue (PVAT) in the modulation of vascular contractility and arterial pressure, focusing on the role of the renin-angiotensin-aldosterone system and oxidative stress/infla... Read More about Modulation of vascular reactivity by perivascular adipose tissue (PVAT).

Personalizing hypertension treatment? (2018)
Journal Article
Withers, S., Saxton, S., & Heagerty, A. (2018). Personalizing hypertension treatment?. Hypertension, 71(6), 1028-1029. https://doi.org/10.1161/HYPERTENSIONAHA.118.11107

Editorial.

Eosinophils are key regulators of perivascular adipose tissue and vascular functionality (2017)
Journal Article
vascular functionality. Scientific reports, 7, 44571. https://doi.org/10.1038/srep44571

Obesity impairs the relaxant capacity of adipose tissue surrounding the vasculature (PVAT) and has been implicated in resultant obesity-related hypertension and impaired glucose intolerance. Resident immune cells are thought to regulate adipocyte a... Read More about Eosinophils are key regulators of perivascular adipose tissue and vascular functionality.

Mechanisms of adiponectin-associated perivascular function in vascular disease (2014)
Journal Article
Withers, S., Bussey, C., Saxton, S., Melrose, H., Watkins, A., & Heagerty, A. (2014). Mechanisms of adiponectin-associated perivascular function in vascular disease. Arteriosclerosis, Thrombosis, and Vascular Biology, 34(8), 1637-42. https://doi.org/10.1161/ATVBAHA.114.303031

The concept that fat cells could influence the circulation and indeed cardiac function has been in existence for ≥20 years and has gained a wide interest and no less excitement as evidence has accrued to suggest that such effects may be profound enou... Read More about Mechanisms of adiponectin-associated perivascular function in vascular disease.