Anticancer Innovative Therapy Congress : highlights from the 10th anniversary edition (2021)
Journal Article
De Santis, F., Fucà, G., Schadendorf, D., Mantovani, A., Magnani, L., Lisanti, M., …Di Nicola, M. (2021). Anticancer Innovative Therapy Congress : highlights from the 10th anniversary edition. Cytokine and Growth Factor Reviews, 59, 1-8. https://doi.org/10.1016/j.cytogfr.2021.02.001

During the Tenth Edition of the Annual Congress on “Anticancer Innovative Therapy” [Milan, 23/24 January 2020], experts in the fields of immuno-oncology, epigenetics, tumor cell signaling, and cancer metabolism shared their latest knowledge on the ro... Read More about Anticancer Innovative Therapy Congress : highlights from the 10th anniversary edition.

Transcriptome of CD8+ tumor-infiltrating T cells : a link between diabetes and colorectal cancer (2021)
Journal Article
Saleh, R., Sasidharan Nair, V., Murshed, K., Abu Nada, M., Elkord, E., & Shaheen, R. (2021). Transcriptome of CD8+ tumor-infiltrating T cells : a link between diabetes and colorectal cancer. Cancer Immunology, Immunotherapy, 70(9), 2625-2638. https://doi.org/10.1007/s00262-021-02879-7

There is an increased risk of colorectal cancer (CRC) development in patients with non-insulin-dependent type 2 diabetes. CD8 T cells have been implicated in diabetes and are crucial for anti-tumor immunity. However, transcriptomic profiling for CD8... Read More about Transcriptome of CD8+ tumor-infiltrating T cells : a link between diabetes and colorectal cancer.

Role of circular RNAs in colorectal tumor microenvironment (2021)
Journal Article
Viralippurath Ashraf, J., Sasidharan Nair, V., Saleh, R., & Elkord, E. (2021). Role of circular RNAs in colorectal tumor microenvironment. Biomedicine and Pharmacotherapy, 137, 111351. https://doi.org/10.1016/j.biopha.2021.111351

Circular RNAs (circRNAs) are a class of endogenous noncoding RNA, which were previously considered as a byproduct of RNA splicing error. Numerous studies have demonstrated the altered expression of circRNAs in organ tissues during pathological condit... Read More about Role of circular RNAs in colorectal tumor microenvironment.

Infection with Trypanosoma lewisi or Trypanosoma musculi may promote the spread of Toxoplasma gondii (2021)
Journal Article
Gao, J., Yi, S., Geng, G., Xu, Z., Hide, G., Lun, Z., & Lai, D. (2021). Infection with Trypanosoma lewisi or Trypanosoma musculi may promote the spread of Toxoplasma gondii. Parasitology, 148(6), 703-711. https://doi.org/10.1017/S0031182021000196

Toxoplasma gondii can infect almost all warm-blooded vertebrates with pathogensis being largely influenced by the host immune status. As important epidemiological hosts, rodents are globally distributed and are also commonly found infected with ha... Read More about Infection with Trypanosoma lewisi or Trypanosoma musculi may promote the spread of Toxoplasma gondii.

Metabolic reprogramming of T regulatory cells in the hypoxic tumor microenvironment (2021)
Journal Article
Sasidharan Nair, V., Saleh, R., Toor, S., Cyprian, F., & Elkord, E. (2021). Metabolic reprogramming of T regulatory cells in the hypoxic tumor microenvironment. Cancer Immunology, Immunotherapy, 70(8), 2103-2121. https://doi.org/10.1007/s00262-020-02842-y

Metabolic dysregulation in the hypoxic tumor microenvironment (TME) is considered as a hallmark of solid tumors, leading to changes in biosynthetic pathways favoring onset, survival and proliferation of malignant cells. Within the TME, hypoxic milieu... Read More about Metabolic reprogramming of T regulatory cells in the hypoxic tumor microenvironment.

Circular and linear : a tale of aptamer selection for the activation of SIRT1 to induce death in cancer cells (2020)
Journal Article
Al-Sudani, B., Ragazzon-Smith, A., Aziz, A., Alansari, R., Ferry, N., Krstic- Demonacos, M., & Ragazzon, P. (2020). Circular and linear : a tale of aptamer selection for the activation of SIRT1 to induce death in cancer cells. RSC Advances, 10(73), 45008-45018. https://doi.org/10.1039/D0RA07857C

It is a challenge to select the right target to treat conditions without affecting non-diseased cells. Cancer belongs to the top 10 causes of death in the world and it remains difficult to treat. Amongst cancer emerging targets, silent information re... Read More about Circular and linear : a tale of aptamer selection for the activation of SIRT1 to induce death in cancer cells.

Long-term trends in helminth infections of wood mice (Apodemus sylvaticus) from the vicinity of Malham Tarn in North Yorkshire, England (2020)
Journal Article
Behnke, J., Rogan, M., Craig, P., Jackson, J., & Hide, G. (2021). Long-term trends in helminth infections of wood mice (Apodemus sylvaticus) from the vicinity of Malham Tarn in North Yorkshire, England. Parasitology, 184(4), 451-463. https://doi.org/10.1017/S0031182020002243

Helminth infections in wood mice (n=483), trapped over a period of 26 years in the woods surrounding Malham Tarn in N. Yorkshire, were analysed. Although ten species of helminths were identified, the overall mean species richness was 1.01 species/m... Read More about Long-term trends in helminth infections of wood mice (Apodemus sylvaticus) from the vicinity of Malham Tarn in North Yorkshire, England.

RNA-seq analysis of colorectal tumor-infiltrating myeloid-derived suppressor cell subsets revealed gene signatures of poor prognosis (2020)
Journal Article
Saleh, R., Sasidharan Nair, V., Al-Dhaheri, M., Khawar, M., Abu Nada, M., Alajez, N., & Elkord, E. (2020). RNA-seq analysis of colorectal tumor-infiltrating myeloid-derived suppressor cell subsets revealed gene signatures of poor prognosis. Frontiers in Oncology, 10, 604906. https://doi.org/10.3389/fonc.2020.604906

Elevated levels of myeloid-derived suppressor cells (MDSCs), including polymorphonuclear MDSCs (PMN-MDSCs) and immature MDSCs (I-MDSCs), are usually associated with disease progression in cancer patients, including colorectal cancer (CRC). However, b... Read More about RNA-seq analysis of colorectal tumor-infiltrating myeloid-derived suppressor cell subsets revealed gene signatures of poor prognosis.

Targeting TIM-3 in solid tumors : innovations in the preclinical and translational realm and therapeutic potential (2020)
Journal Article
Saleh, R., Toor, S., & Elkord, E. (2020). Targeting TIM-3 in solid tumors : innovations in the preclinical and translational realm and therapeutic potential. Expert Opinion on Therapeutic Targets, 24(12), 1251-1262. https://doi.org/10.1080/14728222.2020.1841750

Introduction Immune checkpoint inhibitors (ICIs) have shown a great therapeutic efficacy in cancer patients. However, a significant proportion of cancer patients remain unresponsive or show limited response. T cell immunoglobulin and mucin-domain... Read More about Targeting TIM-3 in solid tumors : innovations in the preclinical and translational realm and therapeutic potential.

Detection and identification of ethanal-derived spin-trapped free radicals using headspace thermal desorption gas chromatography-mass spectrometry (TD-GC-MS) (2020)
Journal Article
Manzoor, K., Mishra, S., & Podmore, I. (2020). Detection and identification of ethanal-derived spin-trapped free radicals using headspace thermal desorption gas chromatography-mass spectrometry (TD-GC-MS). Free Radical Research, 54(10), 745-755. https://doi.org/10.1080/10715762.2020.1841183

In this study, we demonstrate a novel approach to the detection and identification of the products of spin-trapped free radicals. Hydroxyl free radicals were generated by Fenton-based chemistry in the presence of ethanal and the spin-trapping agent... Read More about Detection and identification of ethanal-derived spin-trapped free radicals using headspace thermal desorption gas chromatography-mass spectrometry (TD-GC-MS).

Protein disulfide isomerase A1 regulates breast cancer cell immunorecognition in a manner dependent on redox state (2020)
Journal Article
Alhammad, R., Khunchai, S., Tongmuang, N., Limjindaporn, T., Yenchitsomanus, P., Mutti, L., …Demonacos, C. (2020). Protein disulfide isomerase A1 regulates breast cancer cell immunorecognition in a manner dependent on redox state. Oncology Reports, 44(6), 2406-2418. https://doi.org/10.3892/or.2020.7816

Oxidoreductase protein disulphide isomerases (PDI) are involved in the regulation of a variety of biological processes including the modulation of endoplasmic reticulum (ER) stress, unfolded protein response (UPR), ER‑mitochondria communication and t... Read More about Protein disulfide isomerase A1 regulates breast cancer cell immunorecognition in a manner dependent on redox state.

An evaluation of sorter induced cell stress (SICS) on peripheral blood mononuclear cells (PBMCs) after different sort conditions - are your sorted cells getting SICS? (2020)
Journal Article
Pfister, G., Toor, S., Sasidharan Nair, V., & Elkord, E. (2020). An evaluation of sorter induced cell stress (SICS) on peripheral blood mononuclear cells (PBMCs) after different sort conditions - are your sorted cells getting SICS?. Journal of Immunological Methods, 487, 112902. https://doi.org/10.1016/j.jim.2020.112902

Flow cytometry and fluorescence-activated cell sorting have become invaluable tools to analyze and isolate specific cell populations in a wide range of biomedical research and clinical applications. In countless approaches worldwide, scientists are u... Read More about An evaluation of sorter induced cell stress (SICS) on peripheral blood mononuclear cells (PBMCs) after different sort conditions - are your sorted cells getting SICS?.

Interleukin-33 rescues perivascular adipose tissue anticontractile function in obesity (2020)
Journal Article
Saxton, S., Whitley, A., Potter, R., Withers, S., Grencis, R., & Heagerty, A. (2020). Interleukin-33 rescues perivascular adipose tissue anticontractile function in obesity. American journal of physiology. Heart and circulatory physiology, 319(6), H1387-H1397. https://doi.org/10.1152/ajpheart.00491.2020

Perivascular adipose tissue (PVAT) depots are metabolically active and play a major vasodilator role in healthy lean individuals. In obesity, they become inflamed and eosinophil-depleted and the anticontractile function is lost with the development o... Read More about Interleukin-33 rescues perivascular adipose tissue anticontractile function in obesity.

3D DESI-MS lipid imaging in a xenograft model of glioblastoma : a proof of principle (2020)
Journal Article
Henderson, F., Jones, E., Denbigh, J., Christie, L., Chapman, R., Hoyes, E., …McMahon, A. (2020). 3D DESI-MS lipid imaging in a xenograft model of glioblastoma : a proof of principle. Scientific reports, 10, 16512. https://doi.org/10.1038/s41598-020-73518-x

Desorption electrospray ionisation mass spectrometry (DESI-MS) can image hundreds of molecules in a 2D tissue section, making it an ideal tool for mapping tumour heterogeneity. Tumour lipid metabolism has gained increasing attention over the past dec... Read More about 3D DESI-MS lipid imaging in a xenograft model of glioblastoma : a proof of principle.

Living with Coronavirus (COVID-19) : a brief report (2020)
Journal Article
Khurshid, A., Ahmed, M., Aziz, A., & Amin, R. (2020). Living with Coronavirus (COVID-19) : a brief report. European review for medical and pharmacological sciences (Online), 24(20), 10902-10912. https://doi.org/10.26355/eurrev_202010_23455

The world will never be same after the current COVID-19 pandemic. We may have to live with the coronavirus for a long time. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has resulted in a major burden on the global health... Read More about Living with Coronavirus (COVID-19) : a brief report.

T‐cell responses and therapies against SARS‐CoV‐2 infection (2020)
Journal Article
Toor, S., Saleh, R., Sasidharan Nair, V., Taha, R., & Elkord, E. (2021). T‐cell responses and therapies against SARS‐CoV‐2 infection. Immunology, 162(1), 30-43. https://doi.org/10.1111/imm.13262

Coronavirus disease 2019 (COVID‐19) is caused by SARS‐CoV‐2, a novel coronavirus strain. Some studies suggest that COVID‐19 could be an immune‐related disease, and failure of effective immune responses in initial stages of viral infection could contr... Read More about T‐cell responses and therapies against SARS‐CoV‐2 infection.

Novel organization of mitochondrial minicircles and guide RNAs in the zoonotic pathogen Trypanosoma lewisi (2020)
Journal Article
Li, S., Zhang, X., Lukeš, J., Li, B., Wang, J., Qu, L., …Lun, Z. (2020). Novel organization of mitochondrial minicircles and guide RNAs in the zoonotic pathogen Trypanosoma lewisi. Nucleic Acids Research, 48(17), 9747-9761. https://doi.org/10.1093/nar/gkaa700

Abstract Kinetoplastid flagellates are known for several unusual features, one of which is their complex mitochondrial genome, known as kinetoplast (k) DNA, composed of mutually catenated maxi- and minicircles. Trypanosoma lewisi is a member of the S... Read More about Novel organization of mitochondrial minicircles and guide RNAs in the zoonotic pathogen Trypanosoma lewisi.

Cancer research, treatment, and COVID-19 (2020)
Journal Article
Curley, S., Currell, F., Kirshnan, S., & Krpetic, Z. (2020). Cancer research, treatment, and COVID-19. Cancer Nanotechnology, 11, 7. https://doi.org/10.1101/2020.05.27.20115303

This is an editorial article.

SARS-CoV-2 infection and lung cancer : potential therapeutic modalities (2020)
Journal Article
Gupta, I., Rizeq, B., Elkord, E., Vranic, S., & Al Moustafa, A. (2020). SARS-CoV-2 infection and lung cancer : potential therapeutic modalities. Cancers, 12(8), e2186. https://doi.org/10.3390/cancers12082186

Human coronaviruses, especially SARS-CoV-2, are emerging pandemic infectious diseases with high morbidity and mortality in certain group of patients. In general, SARS-CoV-2 causes symptoms ranging from the common cold to severe conditions accompanied... Read More about SARS-CoV-2 infection and lung cancer : potential therapeutic modalities.

A 2-step synthesis of Combretastatin A-4 and derivatives as potent tubulin assembly inhibitors (2020)
Journal Article
Barnes, N., Parker, A., Mal Ullah, A., Ragazzon, P., & Hadfield, J. (2020). A 2-step synthesis of Combretastatin A-4 and derivatives as potent tubulin assembly inhibitors. Bioorganic and Medicinal Chemistry, 28(19), 115684. https://doi.org/10.1016/j.bmc.2020.115684

A series of combretastatin derivatives were designed and synthesised by a two-step stereoselective synthesis by use of Wittig olefination followed by Suzuki cross-coupling. Interestingly, all new compounds (2a-2i) showed potent cell-based antiprolife... Read More about A 2-step synthesis of Combretastatin A-4 and derivatives as potent tubulin assembly inhibitors.