Outputs (32)

Facile synthesis and biological evaluation of chrysin derivatives (2021)
Journal Article

In this paper, novel synthetic methods, including microwave O-alkylation, were used to produce several chrysin derivatives. These compounds were purified, characterised and tested on different cell lines and bacterial strains. From this family, 7-(2,... Read More about Facile synthesis and biological evaluation of chrysin derivatives.

Syntheses of Combretastatin A‐4 and related stilbenes by using aqueous conditions (2021)
Journal Article
Barnes, N., Ahmed Mal Ullah, A., Ragazzon, P., Charafi, N., & Hadfield, J. (2021). Syntheses of Combretastatin A‐4 and related stilbenes by using aqueous conditions. ChemistrySelect, 6(28), 7082-7086. https://doi.org/10.1002/slct.202101960

Combretastatin A‐4 (CA4) is a potent anti‐mitotic and vascular disrupting agent. Organic chemists have been working to optimize the synthesis of CA4 for the past 3 decades, with methods requiring hazardous solvents and harsh reaction conditions. Here... Read More about Syntheses of Combretastatin A‐4 and related stilbenes by using aqueous conditions.

Synthesis and evaluation of benzoyl containing compounds as potential anti-cancer agents (2020)
Thesis
Ahmed, S. Synthesis and evaluation of benzoyl containing compounds as potential anti-cancer agents. (Dissertation). University of Salford

Seen as one of the major causes of death worldwide, Cancer requires the development of effective treatments in order to combat the disease. However, pharmaceutical companies are faced by the challenge of finding and developing a suitable compound tha... Read More about Synthesis and evaluation of benzoyl containing compounds as potential anti-cancer agents.

Synthesis and evaluation of novel heterocyclic compounds as anticancer agents (2020)
Thesis
Mal ullah, A. Synthesis and evaluation of novel heterocyclic compounds as anticancer agents. (Thesis). University of Salford

There is a clear need for anti-cancer therapies that have effective cytotoxic efficiency and
marginal toxicity, preferably zero. For this goal, researchers have been persevering to
develop new drugs from natural resources. Among them are agents tha... Read More about Synthesis and evaluation of novel heterocyclic compounds as anticancer agents.

A 2-step synthesis of Combretastatin A-4 and derivatives as potent tubulin assembly inhibitors (2020)
Journal Article

A series of combretastatin derivatives were designed and synthesised by a two-step stereoselective synthesis by use of Wittig olefination followed by Suzuki cross-coupling. Interestingly, all new compounds (2a-2i) showed potent cell-based antiprolife... Read More about A 2-step synthesis of Combretastatin A-4 and derivatives as potent tubulin assembly inhibitors.

The synthesis, isolation and evaluation of novel anticancer and antibacterial therapeutics derived from natural products (2020)
Thesis
Omonga, N. The synthesis, isolation and evaluation of novel anticancer and antibacterial therapeutics derived from natural products. (Thesis). University of Salford

This study focused on isolation, synthesis, development and evaluation of novel antimicrobial and anticancer agents from natural product. Natural products have found lead applications in the pharmaceutical industry as sources of chemotherapeutics aga... Read More about The synthesis, isolation and evaluation of novel anticancer and antibacterial therapeutics derived from natural products.

Microwave assisted synthesis of novel bis-flavone dimers as new anticancer agents (2018)
Journal Article

In this study we describe a microwave based click chemistry method used to prepare a family of novel bis-flavone dimers. The substituted 7-hydroxy and 4’-hydroxy flavonoids were linked through a triazole ring. The compounds were easily synthesized an... Read More about Microwave assisted synthesis of novel bis-flavone dimers as new anticancer agents.

Tubulin-binding dibenz[c,e]oxepines: Part 2 Structural variation and biological evaluation as tumour vasculature disrupting agents (2017)
Journal Article
Hadfield, J., Rossington, S., Wallace, T., Shnyder, S., & Williams, K. (2017). Tubulin-binding dibenz[c,e]oxepines: Part 2 Structural variation and biological evaluation as tumour vasculature disrupting agents. Bioorganic and Medicinal Chemistry, 25(5), 1630-1642. https://doi.org/10.1016/j.bmc.2017.01.027

5,7-Dihydro-3,9,10,11-tetramethoxybenz[c,e]oxepin-4-ol 1, prepared from a dibenzyl ether precursor via Pd-catalysed intramolecular direct arylation, possesses broad-spectrum in vitro cytotoxicity towards various tumour cell lines, and induces vascul... Read More about Tubulin-binding dibenz[c,e]oxepines: Part 2 Structural variation and biological evaluation as tumour vasculature disrupting agents.

Expanding the scope of the Babler-Daubin oxidation : 1,3-oxidative transposition of secondary allylic alcohols (2016)
Journal Article
Killoran, P., Rossington, S., Wilkinson, J., & Hadfield, J. (2016). Expanding the scope of the Babler-Daubin oxidation : 1,3-oxidative transposition of secondary allylic alcohols. Tetrahedron Letters, 57(35), 3954-3957. https://doi.org/10.1016/j.tetlet.2016.07.076

We report the catalytic chromium-mediated oxidation of secondary allylic alcohols to give α,β-unsaturated aldehydes with exclusive (E)-stereoselectivity. This facile procedure employs catalytic PCC (5 mol%) and periodic acid (H5IO6) as a co-oxidant.... Read More about Expanding the scope of the Babler-Daubin oxidation : 1,3-oxidative transposition of secondary allylic alcohols.

Three-dimensional imaging and uptake of the anticancer drug combretastatin in cell spheroids and photoisomerization in gels with multiphoton excitation (2015)
Journal Article

The uptake of E-combretastatins, potential pro-drugs of the anticancer Z-isomers, into multicellular spheroids has been imaged by intrinsic fluorescence in three dimensions using two-photon excited fluorescence lifetime imaging with 625 nm ultrafast... Read More about Three-dimensional imaging and uptake of the anticancer drug combretastatin in cell spheroids and photoisomerization in gels with multiphoton excitation.