Outputs (13)

Assessment of an ex vivo porcine lung model to investigate host-microbe interactions in cases of ventilator associated pneumonia (2021)
Thesis
Barber, E. (in press). Assessment of an ex vivo porcine lung model to investigate host-microbe interactions in cases of ventilator associated pneumonia. (Dissertation). University of Salford

VAP is described as a pneumonic lung infection afflicting those that have been mechanically ventilated typically with an endotracheal tube. Unfortunately, there is no singular diagnostic test for VAP (Grossman & Fein, 2000) or ‘gold standard’ for the... Read More about Assessment of an ex vivo porcine lung model to investigate host-microbe interactions in cases of ventilator associated pneumonia.

Proinflammatory cytokines as mediators of phenotypic change in bacteria implicated in ventilator-associated pneumonia (2021)
Thesis
Tompsett, A. Proinflammatory cytokines as mediators of phenotypic change in bacteria implicated in ventilator-associated pneumonia. (Thesis). University of Salford

Ventilator-associated pneumonia (VAP) is a common hospital-acquired infection in intensive care. VAP is associated with increased hospital stay, healthcare costs, and high mortality. VAP is difficult to diagnose and manage appropriately, leading to w... Read More about Proinflammatory cytokines as mediators of phenotypic change in bacteria implicated in ventilator-associated pneumonia.

A myristoyl amide derivative of doxycycline potently targets cancer stem cells (CSCs) and prevents metastasis, without retaining antibiotic activity (2020)
Journal Article
Ozsvari, B., Magalhaes, L., Latimer, J., Kangasmetsa, J., Sotgia, F., & Lisanti, M. (2020). A myristoyl amide derivative of doxycycline potently targets cancer stem cells (CSCs) and prevents metastasis, without retaining antibiotic activity. Frontiers in Oncology, 10, 1528. https://doi.org/10.3389/fonc.2020.01528

Here, we describe the chemical synthesis and biological activity of a new Doxycycline derivative, designed specifically to more effectively target cancer stem cells (CSCs). In this analogue, a myristic acid (14 carbon) moiety is covalently attached t... Read More about A myristoyl amide derivative of doxycycline potently targets cancer stem cells (CSCs) and prevents metastasis, without retaining antibiotic activity.

The efficacy and adverse events of delafloxacin for treating acute bacterial skin and skin structure infections : a systematic review and meta-analysis (2020)
Journal Article
Qasim, S., Tanvir, S., Latimer, J., Qamar, Z., & Niazi, F. (2020). The efficacy and adverse events of delafloxacin for treating acute bacterial skin and skin structure infections : a systematic review and meta-analysis. Journal of Pharmacy and Bioallied Sciences, 12(5), 538-545. https://doi.org/10.4103/jpbs.JPBS_154_20

Background: Acute bacterial skin and skin structure infections (ABSSSI) cause significant morbidity and mortality in hospitalized patients and outpatients as well. Newer fluoroquinolones such as delafloxacin might be a useful medication for treating... Read More about The efficacy and adverse events of delafloxacin for treating acute bacterial skin and skin structure infections : a systematic review and meta-analysis.

Simultaneous assessment of acidogenesis-mitigation and specific bacterial growth-inhibition by dentifrices (2016)
Journal Article
Yilmaz, Ö., Forbes, S., Latimer, J., Sreenivasan, P., & McBain, A. (2016). Simultaneous assessment of acidogenesis-mitigation and specific bacterial growth-inhibition by dentifrices. PLoS ONE, 11(2), e0149390. https://doi.org/10.1371/journal.pone.0149390

Dentifrices can augment oral hygiene by inactivating bacteria and at sub-lethal concentrations may affect bacterial metabolism, potentially inhibiting acidogenesis, the main cause of caries. Reported herein is the development of a rapid method to sim... Read More about Simultaneous assessment of acidogenesis-mitigation and specific bacterial growth-inhibition by dentifrices.

Antibacterial efficacy of a cetylpyridinium chloride-based mouthrinse against Fusobacterium nucleatum and in vitro plaques (2015)
Journal Article
Latimer, J., Munday, J., Buzza, K., Sreenivasan, P., & McBain, A. (2015). Antibacterial efficacy of a cetylpyridinium chloride-based mouthrinse against Fusobacterium nucleatum and in vitro plaques. American journal of dentistry, 28 Spe, 9A-13A

PURPOSE To assess the antimicrobial effects of a fluoride-free and alcohol-free mouthrinse containing 0.075% CPC (test rinse, TR) compared with an otherwise-identical CPC-free control rinse (CR). METHODS Activity against laboratory cultures... Read More about Antibacterial efficacy of a cetylpyridinium chloride-based mouthrinse against Fusobacterium nucleatum and in vitro plaques.

Antibacterial and anti-biofilm activity of mouthrinses containing cetylpyridinium chloride and sodium fluoride (2015)
Journal Article
Latimer, J., Munday, J., Buzza, K., Forbes, S., Sreenivasan, P., & McBain, A. (2015). Antibacterial and anti-biofilm activity of mouthrinses containing cetylpyridinium chloride and sodium fluoride. BMC Microbiology, 15(169), https://doi.org/10.1186/s12866-015-0501-x

Background Cetylpyridinium chloride (CPC) and sodium fluoride augment oral hygiene by inactivating bacteria and inhibiting enamel demineralisation, respectively. However, there are few reports in the literature documenting the antibacterial effic... Read More about Antibacterial and anti-biofilm activity of mouthrinses containing cetylpyridinium chloride and sodium fluoride.

Altered Competitive Fitness, Antimicrobial Susceptibility, and Cellular Morphology in a Triclosan-Induced Small-Colony Variant of Staphylococcus aureus (2015)
Journal Article
Forbes, S., Latimer, J., Bazaid, A., & McBain, A. (2015). Altered Competitive Fitness, Antimicrobial Susceptibility, and Cellular Morphology in a Triclosan-Induced Small-Colony Variant of Staphylococcus aureus. Antimicrobial Agents and Chemotherapy, 59(8), 4809-4816. https://doi.org/10.1128/AAC.00352-15

Staphylococcus aureus can produce small-colony variants (SCVs) that express various phenotypes. While their significance is unclear, SCV propagation may be influenced by relative fitness, antimicrobial susceptibility, and the underlying mechanism. We... Read More about Altered Competitive Fitness, Antimicrobial Susceptibility, and Cellular Morphology in a Triclosan-Induced Small-Colony Variant of Staphylococcus aureus.

Bacteriological effects of dentifrices with and without active ingredients of natural origin (2014)
Journal Article
Ledder, R., Latimer, J., Humphreys, G., Sreenivasan, P., & McBain, A. (2014). Bacteriological effects of dentifrices with and without active ingredients of natural origin. Applied and Environmental Microbiology, 80(20), 6490-6498. https://doi.org/10.1128/AEM.02315-14

Compounds of natural origin are increasingly used as adjuncts to oral hygiene. We have adopted four distinct approaches to assess the antibacterial activity of dentifrices containing natural active ingredients against oral bacteria in several test sy... Read More about Bacteriological effects of dentifrices with and without active ingredients of natural origin.

Fluorescent probe for detection of bacteria : conformational trigger upon bacterial reduction of an azo bridge (2012)
Journal Article
Rattray, N., Zalloum, W., Mansell, D., Latimer, J., Schwalbe, C., Blake, A., …Freeman, S. (2012). Fluorescent probe for detection of bacteria : conformational trigger upon bacterial reduction of an azo bridge. Chemical Communications, 48, 6393-6395. https://doi.org/10.1039/C2CC32521G

Using biomimetic chemical reduction or Clostridium perfringens cell extract containing azoreductase, the dimer-fluorescent probe 2,4-O-bisdansyl-6,7-diazabicyclooct-6-ene, which possesses a conformationally constrained cis-azo bridge, is reduced to t... Read More about Fluorescent probe for detection of bacteria : conformational trigger upon bacterial reduction of an azo bridge.